Actively Recruiting
A Study of AK104+Lenvatinib in Combination With Transarterial Chemoembolization (TACE) Versus TACE in Participants With Incurable/Non-metastatic Hepatocellular Carcinoma
Led by Akeso · Updated on 2025-03-12
469
Participants Needed
4
Research Sites
94 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A study to evaluate cadonilimab (AK104) + lenvatinib in combination with transarterial chemoembolization (TACE) versus TACE in participants with incurable/non-metastatic hepatocellular carcinoma
CONDITIONS
Official Title
A Study of AK104+Lenvatinib in Combination With Transarterial Chemoembolization (TACE) Versus TACE in Participants With Incurable/Non-metastatic Hepatocellular Carcinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with hepatocellular carcinoma confirmed by histology, cytology, or clinical criteria from the American Association for the Study of Liver Diseases
- No evidence of metastasis
- Not suitable for curative surgery, transplantation, or ablation but can receive TACE
- Child Pugh score class A
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 at enrollment
- Measurable disease by RECIST 1.1
- Adequate organ function
You will not qualify if you...
- History of liver transplantation
- History of hepatic encephalopathy
- Uncontrolled arterial hypertension
- Deep venous thrombosis within 3 months before first treatment
- Bleeding events within the last 6 months
- Co-infection with HBV and HCV
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Henan Cancer Hospital
Zhengzhou, Henan, China, 450004
Actively Recruiting
2
Hunan Cancer Hospital
Changsha, Hunan, China, 410006
Actively Recruiting
3
Zhongda Hospital Southeast University
Nanjing, Jiangsu, China, 210009
Actively Recruiting
4
Zhejiang Cancer Hospital
Hangzhou, Zhejiang, China, 310005
Actively Recruiting
Research Team
T
Ting Liu
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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