Actively Recruiting
Study of ALTO-300 in MDD
Led by Alto Neuroscience · Updated on 2025-07-24
321
Participants Needed
45
Research Sites
181 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to determine efficacy differences between ALTO-300 and placebo, used adjunctively to an antidepressant, related to patient characteristics.
CONDITIONS
Official Title
Study of ALTO-300 in MDD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have a diagnosis of moderate to severe major depressive disorder (MDD)
- Currently taking a single SSRI, SNRI, or bupropion for at least 6 weeks with no dose changes in the past 2 weeks
- Willing to comply with all study assessments and procedures
- Not pregnant or breastfeeding at enrollment or during the study
You will not qualify if you...
- Evidence of unstable medical condition
- Nightly use of sleep medication
- Diagnosed bipolar disorder, psychotic disorder, or dementia
- Current moderate or severe substance use disorder
- History of hypersensitivity or allergic reaction to ALTO-300 or its components
- Participation in another mental illness clinical trial with investigational products or devices recently or concurrently
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 45 locations
1
Site 200
Phoenix, Arizona, United States, 85012
Actively Recruiting
2
Site 189
Phoenix, Arizona, United States, 85021
Withdrawn
3
Site 187
Yuma, Arizona, United States, 85364
Actively Recruiting
4
Site 193
Rogers, Arkansas, United States, 72758
Actively Recruiting
5
Site 218
Bellflower, California, United States, 90706
Actively Recruiting
6
Site 217
Glendale, California, United States, 91206
Actively Recruiting
7
Site 335
Lafayette, California, United States, 94549
Actively Recruiting
8
Site 209
Los Angeles, California, United States, 90064
Actively Recruiting
9
Site 219
Mather, California, United States, 95655
Actively Recruiting
10
Site 194
Mission Viejo, California, United States, 92691
Actively Recruiting
11
Site 197
Temecula, California, United States, 92591
Actively Recruiting
12
Site 203
Colorado Springs, Colorado, United States, 80918
Actively Recruiting
13
Site 349
Evergreen, Colorado, United States, 80439
Actively Recruiting
14
Site 214
Norwalk, Connecticut, United States, 06851
Actively Recruiting
15
Site 159
Clermont, Florida, United States, 34711
Actively Recruiting
16
Site 225
Miami Gardens, Florida, United States, 33014
Actively Recruiting
17
Site 190
Miami Lakes, Florida, United States, 33016
Actively Recruiting
18
Site 161
Okeechobee, Florida, United States, 34972
Actively Recruiting
19
Site 221
Tampa, Florida, United States, 33629
Actively Recruiting
20
Site 220
West Palm Beach, Florida, United States, 33407
Actively Recruiting
21
Site 224
Savannah, Georgia, United States, 31405
Actively Recruiting
22
Site 208
Snellville, Georgia, United States, 30078
Actively Recruiting
23
Site 119
Boise, Idaho, United States, 83702
Actively Recruiting
24
Site 310
Chicago, Illinois, United States, 60634
Actively Recruiting
25
Site 201
Marrero, Louisiana, United States, 70072
Terminated
26
Site 198
Monroe, Louisiana, United States, 71201
Terminated
27
Site 215
Jackson, Mississippi, United States, 39216
Actively Recruiting
28
Site 344
Las Vegas, Nevada, United States, 89102
Actively Recruiting
29
Site 114
Albuquerque, New Mexico, United States, 87108
Actively Recruiting
30
Site 191
Rochester, New York, United States, 14618
Terminated
31
Site 192
Staten Island, New York, United States, 10314
Actively Recruiting
32
Site 199
Hickory, North Carolina, United States, 28601
Actively Recruiting
33
Site 202
Cincinnati, Ohio, United States, 45215
Actively Recruiting
34
Site 195
Oklahoma City, Oklahoma, United States, 73112
Actively Recruiting
35
Site 216
Allentown, Pennsylvania, United States, 18104
Actively Recruiting
36
Site 350
Media, Pennsylvania, United States, 19063
Actively Recruiting
37
Site 352
Moosic, Pennsylvania, United States, 18507
Actively Recruiting
38
Site 102
Dallas, Texas, United States, 75235
Withdrawn
39
Site 347
Fort Worth, Texas, United States, 76104
Actively Recruiting
40
Site 148
Fort Worth, Texas, United States, 76244
Withdrawn
41
Site 206
Missouri City, Texas, United States, 77459
Withdrawn
42
Site 353
Plano, Texas, United States, 75093
Not Yet Recruiting
43
Site 196
Richmond, Texas, United States, 77407
Actively Recruiting
44
Site 207
Clinton, Utah, United States, 84015
Actively Recruiting
45
Site 211
Roanoke, Virginia, United States, 24018
Actively Recruiting
Research Team
A
Alto Neuroscience
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here