Actively Recruiting
Role of the Neurovascular System in Spontaneous Coronary Artery Dissection (SCAD)
Led by Mayo Clinic · Updated on 2025-06-12
50
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
M
Mayo Clinic
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying the sympathetic nervous system's role and arterial health in people who have had spontaneous coronary artery dissection (SCAD) compared to healthy individuals matched by age and sex. The study aims to understand differences in arterial thickness, stiffness, baroreflex sensitivity, and the sympathetic response to stress between these two groups. This research is led by the Mayo Clinic and involves adults aged 18 and older. Participants with a history of SCAD and healthy controls will undergo diagnostic tests to assess neurovascular function. These tests include arterial tonometry to measure arterial stiffness, echocardiograms for heart ultrasound imaging, carotid ultrasounds, elastography to evaluate artery elasticity, ankle-brachial index to assess blood flow in peripheral arteries, and microneurography with various stress maneuvers to measure sympathetic nerve activity. During the study, participants will complete these diagnostic assessments at baseline. Researchers will measure key outcomes such as arterial thickness, arterial stiffness, baroreflex sensitivity, and sympathetic responses to stress. The study does not involve treatment but focuses on detailed monitoring and evaluation of neurovascular function. Participation is expected to last through the baseline assessments, with no intervention or long-term treatment planned.
CONDITIONS
Brief Title
A Study to Analyze the Role of Sympathetic Nervous System in Spontaneous Coronary Artery Dissection
Who Can Participate
Eligibility Criteria
You may qualify if you...
- For SCAD patients: history of SCAD as confirmed by coronary angiography or cardiac computed tomography angiography
- For controls: no cardiac disease history
- Female participants
- Age 18 years or older
You will not qualify if you...
- Pregnancy
- Known or suspected unstable cardiac condition within 4 weeks of the study
- Active treatment with anticoagulation or dual antiplatelet therapy
- Prisoner
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo a series of diagnostic studies to assess neurovascular function, including arterial tonometry, echocardiogram, carotid ultrasounds, elastography, ankle-brachial index, and microneurography with sympathoexcitatory maneuvers.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Mayo Clinic Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
P
Pamela Engrav
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
2
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