Actively Recruiting
A Study of Angiotensin-II Receptor Blocker on Cardiovascular Remodeling (VALUE Trial)
Led by Mayo Clinic · Updated on 2025-08-03
120
Participants Needed
1
Research Sites
217 weeks
Total Duration
On this page
Sponsors
M
Mayo Clinic
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate the effectiveness and mechanism of action of Losartan in the treatment of coarctation of aorta.
CONDITIONS
Official Title
A Study of Angiotensin-II Receptor Blocker on Cardiovascular Remodeling (VALUE Trial)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 or older
- Confirmed repaired coarctation of the aorta
- Blood pressure systolic 100-139 mmHg based on 3 office measurements
- Diagnosed with blood pressure stage 1 hypertension
You will not qualify if you...
- Currently taking beta blocker therapy
- Pregnant or breastfeeding
- Estimated glomerular filtration rate (eGFR) less than 30
- High potassium levels in the blood (serum potassium over 5.5 mmol/L)
- Severe narrowing or leakage of the aortic or mitral heart valves
- Diagnosed with epicardial coronary artery disease
- Received antihypertensive medications within the past year
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
A
ACHD Research Program
CONTACT
A
Alexander Egbe, MBBS, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
3
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