Actively Recruiting
Study of AR-14034 in Participants With Neovascular Age-Related Macular Degeneration (nAMD)
Led by Alcon Research · Updated on 2026-01-06
140
Participants Needed
42
Research Sites
199 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The primary purpose of this study is to evaluate the safety and durability of single- and repeat administration of AR-14034 Sustained Release (SR) in subjects with neovascular age-related macular degeneration (nAMD).
CONDITIONS
Official Title
Study of AR-14034 in Participants With Neovascular Age-Related Macular Degeneration (nAMD)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Presence of an active choroidal neovascularization lesion secondary to age-related macular degeneration
- Best corrected visual acuity (BCVA) between 80 and 35 letters (20/25 to 20/200 Snellen equivalent) in the study eye
- BCVA greater than 20 letters (approximately 20/400 Snellen equivalent) in the non-study eye
- Media clarity and pupillary dilation sufficient for planned study procedures in the study eye
- Capable of giving signed informed consent and complying with study requirements
- For Stage 1: 3 to 6 prior anti-VEGF treatments in the study eye within 8 months, with anatomic response
- For Stage 2: treatment-naïve or diagnosed with exudative neovascular age-related macular degeneration in the study eye
You will not qualify if you...
- History or current ocular disease in the study eye other than nAMD that may require intervention during the study
- Structural damage to the macula likely to prevent vision improvement after nAMD resolution
- Any active intraocular or periocular infection or inflammation
- Anti-VEGF treatment in the study eye within 28 days before Week 1 (Stage 1) or within 56 days before screening (Stage 2)
- Uncontrolled glaucoma in the study eye
- Uncontrolled blood pressure
- Females of child-bearing potential who are pregnant, nursing, intending to become pregnant, or unwilling to use contraception during the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 42 locations
1
Trinity Research Group
Dothan, Alabama, United States, 36301
Actively Recruiting
2
Associated Retina Consultants - Gilbert
Gilbert, Arizona, United States, 85297
Actively Recruiting
3
Associated Retina Consultants - Phoenix
Phoenix, Arizona, United States, 85020
Actively Recruiting
4
Retina Associates of SW PC
Tucson, Arizona, United States, 85704
Actively Recruiting
5
The Retina Partners
Encino, California, United States, 91436
Not Yet Recruiting
6
Retina Associates of Orange County
Laguna Hills, California, United States, 92653
Actively Recruiting
7
Northern California Retina Vitreous Associates Medical Group
Mountain View, California, United States, 94040
Actively Recruiting
8
Eye Research Foundation
Newport Beach, California, United States, 92663
Not Yet Recruiting
9
Azul Vision Pasadena
Pasadena, California, United States, 99107
Not Yet Recruiting
10
Retina Consultants of Southern Colorado
Colorado Springs, Colorado, United States, 80809
Actively Recruiting
11
Retina Group of New England | Waterford
Waterford, Connecticut, United States, 06385
Actively Recruiting
12
Florida Retina Institute
Jacksonville, Florida, United States, 32216
Not Yet Recruiting
13
Mid Florida Eye Center
Mt. Dora, Florida, United States, 32757
Not Yet Recruiting
14
Florida Retina Institute
Orlando, Florida, United States, 32806
Actively Recruiting
15
Retina Specialty Institute
Pensacola, Florida, United States, 32503
Actively Recruiting
16
Eye Associates of Pinellas
Pinellas Park, Florida, United States, 33782
Actively Recruiting
17
Center for Retina and Macular Disease
Winter Haven, Florida, United States, 33880
Actively Recruiting
18
Southeast Retina Center
Augusta, Georgia, United States, 30909
Not Yet Recruiting
19
Thomas Eye Group Main Office
Sandy Springs, Georgia, United States, 30328
Actively Recruiting
20
University Retina and Macula Associates, PC
Oak Forest, Illinois, United States, 60452
Actively Recruiting
21
Twin Cities Eye Consultants
Coon Rapids, Minnesota, United States, 55433
Actively Recruiting
22
Mississippi Retina Associates
Madison, Mississippi, United States, 39110
Actively Recruiting
23
Vision Research Center Eye Associates of New Mexico
Albuquerque, New Mexico, United States, 87109
Not Yet Recruiting
24
NYC Retina - Queens
Forest Hills, New York, United States, 11375
Actively Recruiting
25
University Hospitals Cleveland Medical Center
Cleveland, Ohio, United States, 44106
Not Yet Recruiting
26
Verum Research, LLC
Eugene, Oregon, United States, 97401
Actively Recruiting
27
Erie Retina Research
Erie, Pennsylvania, United States, 16507
Actively Recruiting
28
MidAtlantic Retina Research
Philadelphia, Pennsylvania, United States, 19107
Actively Recruiting
29
Retina Consultants of Carolina
Greenville, South Carolina, United States, 29605
Actively Recruiting
30
Carolina Eyecare Physicians LLC
Mt. Pleasant, South Carolina, United States, 29464
Actively Recruiting
31
Retina Research Institute of Texas
Abilene, Texas, United States, 79606
Actively Recruiting
32
Texas Retina Associates - Arlington
Arlington, Texas, United States, 76012
Not Yet Recruiting
33
Austin Research Center for Retina
Austin, Texas, United States, 78705
Actively Recruiting
34
Austin Retina Associates
Austin, Texas, United States, 78705
Actively Recruiting
35
Austin Clinical Research, LLC
Austin, Texas, United States, 78750
Actively Recruiting
36
Star Vision Research
Burleson, Texas, United States, 76028
Not Yet Recruiting
37
Texas Retina Associates
Dallas, Texas, United States, 75231
Actively Recruiting
38
Berkeley Eye Center
Houston, Texas, United States, 77027
Not Yet Recruiting
39
Retina Consultants of Texas - San Antonio
San Antonio, Texas, United States, 78251
Not Yet Recruiting
40
Austin Retina Associates (San Marcos)
San Marcos, Texas, United States, 78666
Not Yet Recruiting
41
Retina Research Center of Southern Utah
St. George, Utah, United States, 84790
Not Yet Recruiting
42
Pacific Northwest Retina
Burlington, Washington, United States, 98233
Actively Recruiting
Research Team
A
Alcon Call Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
5
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