Actively Recruiting

Phase 2
Age: 18Years +
All Genders
NCT06297226

Study of Arlocabtagene Autoleucel (BMS-986393) a GPRC5D-directed CAR T Cell Therapy in Adult Participants With Relapsed or Refractory Multiple Myeloma

Led by Juno Therapeutics, Inc., a Bristol-Myers Squibb Company · Updated on 2026-02-10

230

Participants Needed

52

Research Sites

431 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The purpose of this study is to evaluate the effectiveness and safety of Arlocabtagene Autoleucel (BMS-986393) in participants with relapsed or refractory multiple myeloma.

CONDITIONS

Official Title

Study of Arlocabtagene Autoleucel (BMS-986393) a GPRC5D-directed CAR T Cell Therapy in Adult Participants With Relapsed or Refractory Multiple Myeloma

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Documented diagnosis of multiple myeloma as per International Myeloma Working Group criteria
  • Received at least 4 classes of multiple myeloma treatment including immunomodulatory drugs, proteasome inhibitors, anti-CD38 monoclonal antibodies, anti-BCMA therapy, and at least 3 prior lines of therapy
  • Documented disease progression during or after last anti-myeloma regimen
  • Measurable disease during screening
  • Eastern Cooperative Oncology Group performance status of 0 or 1
Not Eligible

You will not qualify if you...

  • Active or history of central nervous system involvement with multiple myeloma
  • Active systemic fungal, bacterial, viral, or other infection despite appropriate treatment at leukapheresis
  • Severe infection, sepsis, or bacteremia within 28 days prior to leukapheresis
  • Prior therapy targeting GPRC5D or other prior multiple myeloma treatment without required washout before leukapheresis
  • Other protocol-defined inclusion/exclusion criteria apply

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 52 locations

1

University of Alabama at Birmingham

Birmingham, Alabama, United States, 35294-3300

Actively Recruiting

2

Banner MD Anderson Cancer Center

Gilbert, Arizona, United States, 85234

Actively Recruiting

3

University of Arkansas for Medical Sciences

Little Rock, Arkansas, United States, 72205

Actively Recruiting

4

UCLA Hematology/Oncology - Westwood (Building 200 Suite 214)

Los Angeles, California, United States, 90095

Actively Recruiting

5

UCSF Helen Diller Medical Center at Parnassus Heights

San Francisco, California, United States, 94143

Actively Recruiting

6

Colorado Blood Cancer Institute

Denver, Colorado, United States, 80218

Actively Recruiting

7

Mayo Clinic in Florida

Jacksonville, Florida, United States, 32224

Actively Recruiting

8

Miami Cancer Institute at Baptist Health, Inc.

Miami, Florida, United States, 33176

Actively Recruiting

9

Moffitt Cancer Center

Tampa, Florida, United States, 33612

Actively Recruiting

10

Winship Cancer Institute of Emory University

Atlanta, Georgia, United States, 30322

Actively Recruiting

11

Northside Hospital

Atlanta, Georgia, United States, 30342

Actively Recruiting

12

Northwestern Memorial Hospital

Chicago, Illinois, United States, 60611

Actively Recruiting

13

University of Chicago Medical Center

Chicago, Illinois, United States, 60637

Actively Recruiting

14

University of Iowa

Iowa City, Iowa, United States, 52242

Actively Recruiting

15

The University of Kansas Cancer Center - Westwood

Westwood, Kansas, United States, 66205

Actively Recruiting

16

Norton Women's and Children's Hospital

Louisville, Kentucky, United States, 40207

Actively Recruiting

17

Local Institution - 0065

Baltimore, Maryland, United States, 21218

Withdrawn

18

Massachusetts General Hospital

Boston, Massachusetts, United States, 02114

Actively Recruiting

19

Dana-Farber Cancer Institute

Boston, Massachusetts, United States, 02215

Actively Recruiting

20

Mayo Clinic in Rochester, Minnesota

Rochester, Minnesota, United States, 55905

Actively Recruiting

21

Washington University School of Medicine

St Louis, Missouri, United States, 63110

Actively Recruiting

22

Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, United States, 08901

Actively Recruiting

23

Roswell Park Cancer Institute

Buffalo, New York, United States, 14263

Actively Recruiting

24

Icahn School of Medicine at Mount Sinai

New York, New York, United States, 10029

Actively Recruiting

25

Memorial Sloan Kettering Cancer Center

New York, New York, United States, 10065

Actively Recruiting

26

University of North Carolina Medical Center

Chapel Hill, North Carolina, United States, 27599

Actively Recruiting

27

Local Institution - 0067

Charlotte, North Carolina, United States, 28204

Withdrawn

28

Oncology Hematology Care

Cincinnati, Ohio, United States, 45242

Actively Recruiting

29

The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer Center

Columbus, Ohio, United States, 43210

Actively Recruiting

30

Oregon Health and Science University

Portland, Oregon, United States, 97239

Actively Recruiting

31

Local Institution - 0070

Philadelphia, Pennsylvania, United States, 19107

Not Yet Recruiting

32

Tennessee Oncology

Nashville, Tennessee, United States, 37203

Actively Recruiting

33

Vanderbilt University Medical Center

Nashville, Tennessee, United States, 37232

Actively Recruiting

34

Local Institution - 0069

Austin, Texas, United States, 78704

Withdrawn

35

UT Southwestern Medical Center

Dallas, Texas, United States, 75390

Actively Recruiting

36

University of Texas MD Anderson Cancer Center

Houston, Texas, United States, 77030

Actively Recruiting

37

Methodist HealthCare System of San Antonio Clinical Trials Office, Texas Transplant Institute

San Antonio, Texas, United States, 78229

Actively Recruiting

38

LDS Hospital

Salt Lake City, Utah, United States, 84143

Actively Recruiting

39

Virginia Oncology Associates

Norfolk, Virginia, United States, 23502

Actively Recruiting

40

Fred Hutchinson Cancer Center

Seattle, Washington, United States, 98109

Actively Recruiting

41

University Hospital and UW Health Clinics

Madison, Wisconsin, United States, 53792

Actively Recruiting

42

Royal Prince Alfred Hospital

Camperdown, New South Wales, Australia, 2050

Actively Recruiting

43

Royal Brisbane and Women's Hospital

Brisbane, Queensland, Australia, 4029

Actively Recruiting

44

The Alfred Hospital

Melbourne, Victoria, Australia, 3004

Actively Recruiting

45

St Vincent's Hospital

Melbourne, Victoria, Australia, 3065

Actively Recruiting

46

Arthur J.E. Child Comprehensive Cancer Centre

Calgary, Alberta, Canada, T2N 5G2

Actively Recruiting

47

McGill University Health Centre

Montreal, Quebec, Canada, H4A 3J1

Actively Recruiting

48

Nagoya City University Hospital

Nagoya, Aichi-ken, Japan, 467-8602

Actively Recruiting

49

Hyogo Medical University Hospital

Nishinomiya, Hyōgo, Japan, 663-8501

Actively Recruiting

50

Chiba University Hospital

Chiba, Japan, 260-8677

Actively Recruiting

51

University Hospital,Kyoto Prefectural University of Medicine

Kyoto, Japan, 602-8566

Actively Recruiting

52

Japanese Red Cross Medical Center

Tokyo, Japan, 150-8935

Actively Recruiting

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Research Team

B

BMS Clinical Trials Contact Center www.BMSClinicalTrials.com

CONTACT

F

First line of the email MUST contain NCT # and Site #.

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

2

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