Actively Recruiting
Study to Assess Adverse Events and Change in Disease Activity When Oral ABBV-932 is Added to Antidepressant Therapies in Adult Participants With Generalized Anxiety Disorder
Led by AbbVie · Updated on 2026-01-23
315
Participants Needed
52
Research Sites
78 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Generalized anxiety disorder (GAD) is usually treated with antidepressant therapy (ADT); however, sometimes ADTs alone are not enough to adequately treat GAD. The purpose of this study is to assess how safe and effective ABBV-932 is when added to the antidepressant therapies in adult participants with GAD who have had an inadequate response ADTs. ABBV-932 is an investigational drug being developed for the adjunctive treatment of GAD. Participants will be randomly assigned to receive ABBV-932 or Placebo in addition to their currently prescribed ADTs. There is 1 in 3 chance of participants assigned to Placebo. Approximately 315 adult participants with GAD and inadequate response to ADTs will be enrolled in approximately 50 sites in the United States and Puerto Rico. Participants will receive oral capsules of ABBV-932 or matching placebo in addition to their prescribed ADT for 6 weeks and then will be followed for an additional 4 week follow-up period. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.
CONDITIONS
Official Title
Study to Assess Adverse Events and Change in Disease Activity When Oral ABBV-932 is Added to Antidepressant Therapies in Adult Participants With Generalized Anxiety Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Meet Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR) criteria for generalized anxiety disorder (GAD) confirmed by the Mini International Neuropsychiatric Interview (MINI).
- Currently taking one of the Food and Drug Administration (FDA) approved antidepressant therapies (ADT) for GAD (i.e., escitalopram, paroxetine, duloxetine, or venlafaxine ER) with an inadequate response to an adequate dose (per label) and duration (>= 8 weeks) as verified by a baseline Hamilton Anxiety Rating Scale (HAM-A) total score >= 20 and Clinical Global Impression of Severity Scale (CGI-S GAD) >= 4.
You will not qualify if you...
- Have a Montgomery-Åsberg Depression Rating Scale (MADRS) score >= 20.
- New diagnosis or exacerbation of major depression in the last 6 months.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 52 locations
1
University of Alabama - Huntsville Regional Medical Campus /ID# 267818
Huntsville, Alabama, United States, 35801
Actively Recruiting
2
Ima Clinical Research Phoenix (Alea) /ID# 275737
Phoenix, Arizona, United States, 85012
Actively Recruiting
3
Noble Clinical Research /ID# 267952
Tucson, Arizona, United States, 85704
Completed
4
Advanced Research Center /ID# 267874
Anaheim, California, United States, 92805
Actively Recruiting
5
Axiom Research /ID# 267814
Colton, California, United States, 92324
Actively Recruiting
6
Sun Valley Research Center /ID# 267864
Imperial, California, United States, 92251
Actively Recruiting
7
Synergy San Diego /ID# 267879
Lemon Grove, California, United States, 91945
Actively Recruiting
8
Alliance for Research Alliance for Wellness /ID# 267911
Long Beach, California, United States, 90807
Actively Recruiting
9
NRC Research Institute DTLA /ID# 267832
Los Angeles, California, United States, 90015
Actively Recruiting
10
Excell Research /ID# 267918
Oceanside, California, United States, 92056
Actively Recruiting
11
Viking Clinical Research Center - Temecula /ID# 268598
Temecula, California, United States, 92591
Actively Recruiting
12
Sunwise Clinical Research /ID# 267863
Walnut Creek, California, United States, 94596
Actively Recruiting
13
Connecticut Clinical Research - Cromwell /ID# 271241
Cromwell, Connecticut, United States, 06416
Actively Recruiting
14
Cns Healthcare - Jacksonville /ID# 268588
Jacksonville, Florida, United States, 32256
Actively Recruiting
15
Accel Research Sites Network - St. Pete /ID# 267821
Largo, Florida, United States, 33777
Actively Recruiting
16
K2 Medical Research, LLC /ID# 267841
Maitland, Florida, United States, 32751
Actively Recruiting
17
GMI Florida - Central Miami Medical Institute /ID# 267839
Miami, Florida, United States, 33125
Actively Recruiting
18
Allied Biomedical Res Inst Inc /ID# 267813
Miami, Florida, United States, 33155
Actively Recruiting
19
Apg Research /ID# 271707
Orlando, Florida, United States, 32803
Actively Recruiting
20
Psych Atlanta /ID# 267878
Marietta, Georgia, United States, 30060
Actively Recruiting
21
iResearch Savannah /ID# 267865
Savannah, Georgia, United States, 31405
Actively Recruiting
22
University of Chicago Medical Center /ID# 275131
Chicago, Illinois, United States, 60637
Actively Recruiting
23
Collective Medical Research /ID# 272015
Overland Park, Kansas, United States, 66210
Actively Recruiting
24
CenExel /ID# 267853
Gaithersburg, Maryland, United States, 20877-1407
Actively Recruiting
25
Elixia, LLC /ID# 267815
Springfield, Massachusetts, United States, 01103
Actively Recruiting
26
Psychiatric Care And Research Center /ID# 271701
O'Fallon, Missouri, United States, 63368
Actively Recruiting
27
St. Charles Psychiatric Associates /ID# 271202
Saint Charles, Missouri, United States, 63304
Actively Recruiting
28
Arch Clinical Trials /ID# 267851
St Louis, Missouri, United States, 63125
Actively Recruiting
29
Ima Clinical Research Las Vegas (Altea) /ID# 275731
Las Vegas, Nevada, United States, 89102
Actively Recruiting
30
Duplicate_Oasis Clinical Research, LLC /ID# 267953
Las Vegas, Nevada, United States, 89121
Completed
31
Princeton Medical Institute /ID# 267877
Princeton, New Jersey, United States, 08540
Actively Recruiting
32
Bio Behavioral Health /ID# 267919
Toms River, New Jersey, United States, 08755
Actively Recruiting
33
Integrative Clinical Trials /ID# 279519
Brooklyn, New York, United States, 11229
Actively Recruiting
34
New Hope Clinical Research - Inpatient unit /ID# 267810
Charlotte, North Carolina, United States, 28211
Actively Recruiting
35
Quest Therapeutics of Avon /ID# 267829
Avon Lake, Ohio, United States, 44012-1004
Actively Recruiting
36
University Of Cincinnati Medical Center /ID# 271704
Cincinnati, Ohio, United States, 45219
Actively Recruiting
37
The Ohio State University /ID# 267924
Columbus, Ohio, United States, 43210
Actively Recruiting
38
Sooner Clinical Research /ID# 267881
Oklahoma City, Oklahoma, United States, 73116
Actively Recruiting
39
Lehigh Center for Clinical Research /ID# 267908
Allentown, Pennsylvania, United States, 18103
Actively Recruiting
40
Suburban Research Associates /ID# 267868
West Chester, Pennsylvania, United States, 19380-4370
Actively Recruiting
41
Coastal Carolina Research Center, LLC /ID# 267826
Charleston, South Carolina, United States, 29492
Actively Recruiting
42
Psychiatric Consultants - Franklin /ID# 275133
Franklin, Tennessee, United States, 37067
Actively Recruiting
43
FutureSearch Trials of Dallas /ID# 267870
Dallas, Texas, United States, 75231
Actively Recruiting
44
Relaro Medical Trials /ID# 270241
Dallas, Texas, United States, 75243
Actively Recruiting
45
Perceptive Pharma Research /ID# 267836
Richmond, Texas, United States, 77407
Actively Recruiting
46
Family Psychiatry Of The Woodlands /ID# 275173
The Woodlands, Texas, United States, 77381
Actively Recruiting
47
Grayline Research Center /ID# 267811
Wichita Falls, Texas, United States, 76309
Actively Recruiting
48
Northwest Clinical Research Center /ID# 267916
Bellevue, Washington, United States, 98007
Actively Recruiting
49
Core Clinical Research /ID# 270058
Everett, Washington, United States, 98201
Actively Recruiting
50
INSPIRA Clinical Research /ID# 267822
San Juan, Puerto Rico, 00918-3014
Actively Recruiting
51
Instituto De Neurologia Dra. Ivonne Fraga, Psc /ID# 267793
San Juan, Puerto Rico, 00918
Actively Recruiting
52
BDH Research /ID# 267787
San Juan, Puerto Rico, 00927
Actively Recruiting
Research Team
A
ABBVIE CALL CENTER
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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