Actively Recruiting
Study to Assess the Adverse Events of Oral ABBV-932 in Adult Participants With Depressive Episodes Associated With Bipolar I or II Disorder
Led by AbbVie · Updated on 2026-04-07
200
Participants Needed
49
Research Sites
78 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Bipolar disorder is a severe chronic mood disorder that affects up to 4% of the adult population in the United States. The purpose of this study is to assess how safe and effective ABBV-932 is in treating participants with depressive episodes associated with bipolar I or II disorder. ABBV-932 is an investigational drug being developed for the treatment of depressive episodes in adult participants with bipolar I or II disorder. Participants with bipolar I or II disorder who are currently experiencing a depressive episode will enter the study and be treated with open-label ABBV-932. Approximately 200 adult participants with bipolar I or II disorder will be enrolled in approximately 50 sites in the United States and Puerto Rico. Participants will receive oral capsules of ABBV-932 for a 26-week treatment period. The treatment period will be followed by a safety follow-up (SFU) period of 30 days. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regularly scheduled visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.
CONDITIONS
Official Title
Study to Assess the Adverse Events of Oral ABBV-932 in Adult Participants With Depressive Episodes Associated With Bipolar I or II Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Body Mass Index (BMI) between 18.0 and 40.0 kg/m2, inclusive
- Diagnosis of bipolar I or II disorder without psychotic features, currently experiencing a depressive episode lasting at least 4 weeks but not more than 12 months
- Normal or clinically insignificant abnormal physical exam, laboratory tests, vital signs, and 12-lead ECG at screening
- No psychiatric hospitalization in the past 3 months
- No lifetime history of schizophrenia, psychotic disorders, dissociative disorders, or neurocognitive disorders
- No moderate or severe substance use disorder (except nicotine) in the past 6 months
You will not qualify if you...
- Young Mania Rating Scale (YMRS) score greater than 12 at baseline
- History of allergic reaction or significant sensitivity to ABBV-932 or similar products
- Any concurrent medical condition that could interfere with the study, affect results, or pose risk, including unstable conditions or history of malignancy (except treated basal or squamous cell carcinoma)
- Significant hematologic, endocrine, cardiovascular, respiratory, renal (eGFR < 30 mL/min), hepatic (including severe impairment), gastrointestinal, or neurological disorders unless stable for over 1 year and not requiring prohibited medications
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 49 locations
1
Ima Clinical Research Phoenix (Alea) /ID# 278047
Phoenix, Arizona, United States, 85012
Actively Recruiting
2
Advanced Research Center /ID# 273474
Anaheim, California, United States, 92805
Actively Recruiting
3
Axiom Research /ID# 273482
Colton, California, United States, 92324
Actively Recruiting
4
Collaborative Neuroscience Research - Garden Grove /ID# 273492
Garden Grove, California, United States, 92845
Actively Recruiting
5
Sun Valley Research Center /ID# 273472
Imperial, California, United States, 92251
Actively Recruiting
6
Synergy San Diego /ID# 278340
Lemon Grove, California, United States, 91945
Actively Recruiting
7
Alliance for Research Alliance for Wellness /ID# 273477
Long Beach, California, United States, 90807
Actively Recruiting
8
Nrc Research Institute - Los Angeles /ID# 278450
Los Angeles, California, United States, 90015
Actively Recruiting
9
Excell Research /ID# 273483
Oceanside, California, United States, 92056
Actively Recruiting
10
Inland Psychiatric Medical Group Inc. /ID# 273471
Temecula, California, United States, 92591
Actively Recruiting
11
Sunwise Clinical Research /ID# 278165
Walnut Creek, California, United States, 94596
Actively Recruiting
12
Connecticut Clinical Research - Cromwell /ID# 278116
Cromwell, Connecticut, United States, 06416
Actively Recruiting
13
Cns Healthcare - Jacksonville /ID# 278332
Jacksonville, Florida, United States, 32256
Actively Recruiting
14
GMI Florida - Central Miami Medical Institute /ID# 273486
Miami, Florida, United States, 33125
Actively Recruiting
15
Allied Biomedical Res Inst Inc /ID# 273476
Miami, Florida, United States, 33155
Actively Recruiting
16
Floridian Clinical Research - Miami Lakes /ID# 279379
Miami Lakes, Florida, United States, 33016
Actively Recruiting
17
K2 Medical Research - Orlando - South Orlando Avenue /ID# 273487
Orlando, Florida, United States, 32751
Actively Recruiting
18
Apg Research /ID# 278439
Orlando, Florida, United States, 32803
Actively Recruiting
19
Segal Trials - West Broward Outpatient Research Site /ID# 273496
Tamarac, Florida, United States, 33319-4985
Actively Recruiting
20
Health Synergy Clinical Research /ID# 279384
West Palm Beach, Florida, United States, 33407
Actively Recruiting
21
Trialmed /ID# 278046
Atlanta, Georgia, United States, 30328
Actively Recruiting
22
Atlanta Center for Medical Research /ID# 278827
Atlanta, Georgia, United States, 30331
Actively Recruiting
23
Revive Research Institute - Elgin /ID# 279756
Elgin, Illinois, United States, 60123
Actively Recruiting
24
Benchmark Research /ID# 273490
Shreveport, Louisiana, United States, 71101
Completed
25
Pharmasite Research, Inc. /ID# 279163
Baltimore, Maryland, United States, 21208
Actively Recruiting
26
Elixia, LLC /ID# 278446
Springfield, Massachusetts, United States, 01103
Actively Recruiting
27
MSB Neuroscience /ID# 278168
Jackson, Mississippi, United States, 39216-4643
Actively Recruiting
28
Arch Clinical Trials /ID# 273481
St Louis, Missouri, United States, 63125
Actively Recruiting
29
Alivation Research /ID# 279464
Lincoln, Nebraska, United States, 68526
Actively Recruiting
30
Ima Clinical Research Las Vegas (Altea) /ID# 278054
Las Vegas, Nevada, United States, 89102
Actively Recruiting
31
Redbird Research /ID# 279475
Las Vegas, Nevada, United States, 89119
Actively Recruiting
32
Bio Behavioral Health /ID# 273478
Toms River, New Jersey, United States, 08755
Actively Recruiting
33
Integrative Clinical Trials /ID# 278040
Brooklyn, New York, United States, 11229
Actively Recruiting
34
Neurobehavioral Research /ID# 273470
Cedarhurst, New York, United States, 11516
Actively Recruiting
35
Ima Clinical Research - Manhattan /ID# 278941
New York, New York, United States, 10036
Actively Recruiting
36
New Hope Clinical Research - Inpatient unit /ID# 273468
Charlotte, North Carolina, United States, 28211
Actively Recruiting
37
Quest Therapeutics of Avon Lake /ID# 273484
Avon Lake, Ohio, United States, 44012
Actively Recruiting
38
OSU Psychiatry Department /ID# 273495
Columbus, Ohio, United States, 43210
Actively Recruiting
39
Sooner Clinical Research /ID# 273491
Oklahoma City, Oklahoma, United States, 73116
Actively Recruiting
40
Summit Research Network - Portland - Northwest Vaughn Street /ID# 278084
Portland, Oregon, United States, 97210
Actively Recruiting
41
Lehigh Center for Clinical Research /ID# 273466
Allentown, Pennsylvania, United States, 18103
Actively Recruiting
42
FutureSearch Trials of Dallas /ID# 273473
Dallas, Texas, United States, 75231
Actively Recruiting
43
Epic Medical Research - DeSoto /ID# 278045
DeSoto, Texas, United States, 75115
Actively Recruiting
44
Perceptive Pharma Research /ID# 273485
Richmond, Texas, United States, 77407
Actively Recruiting
45
Family Psychiatry Of The Woodlands /ID# 278050
The Woodlands, Texas, United States, 77381
Actively Recruiting
46
Northwest Clinical Research Center /ID# 273480
Bellevue, Washington, United States, 98007
Actively Recruiting
47
Core Clinical Research /ID# 273498
Everett, Washington, United States, 98201
Actively Recruiting
48
INSPIRA Clinical Research /ID# 274670
San Juan, Puerto Rico, 00918-3014
Actively Recruiting
49
BDH Research /ID# 274677
San Juan, Puerto Rico, 00927
Actively Recruiting
Research Team
A
ABBVIE CALL CENTER
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here