Actively Recruiting
A Study to Assess Anti-Tumor Activity of Intravenously (IV) Infused Carboplatin With Mirvetuximab Soravtansine in Participants With Newly Diagnosed Folate Receptor Alpha (FRα)Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.
Led by AbbVie · Updated on 2026-05-13
140
Participants Needed
61
Research Sites
219 weeks
Total Duration
On this page
Sponsors
A
AbbVie
Lead Sponsor
G
GOG Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
Cancer is a condition where cells in a specific part of body grow and reproduce uncontrollably. The purpose of this study is to assess the safety and efficacy of neoadjuvant carboplatin and mirvetuximab soravtansine in participants with folate receptor alpha (FRα) -expressing advanced-stage serous epithelial ovarian, fallopian tube or primary peritoneal cancer (EOC). Mirvetuximab Soravtansine (MIRV) is an investigational antibody drug conjugate designed to selectively kill cancer cells. The antibody (protein) part of MIRV targets tumors by delivering a cell-killing drug to cancer cells carrying a protein called folate receptor alpha (FRα). This is a single arm study in adult participants with advanced-stage Fédération Internationale de Gynécologie et d'Obstétrique (FIGO) III-IV FRα-expressing serous EOC. Around 140 participants will be enrolled in the study at approximately 80 sites in the United States. Participants will receive intravenous infusion of MIRV in combination with carboplatin on day 1 of each cycle, every 21 days for up to 6 - 9 Cycles. The total study duration will be approximately 3 years . There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic and may require frequent medical assessments, blood tests, and scans.
CONDITIONS
Official Title
A Study to Assess Anti-Tumor Activity of Intravenously (IV) Infused Carboplatin With Mirvetuximab Soravtansine in Participants With Newly Diagnosed Folate Receptor Alpha (FRα)Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female participants aged 18 years or older
- Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2
- Appropriate candidate for neoadjuvant chemotherapy as judged by investigator or treating physician
- Biopsy-confirmed high-grade, serous epithelial ovarian, fallopian tube, or primary peritoneal cancer
- Stage III or IV disease by the FIGO staging system
- Folate Receptor Alpha (FRα) expression positive, defined as ≥75% of viable tumor cells with moderate (≥2+) membrane staining
- Measurable disease by RECIST Version 1.1 criteria
You will not qualify if you...
- Tumors with endometrioid, clear cell, mucinous, or sarcomatous histology, mixed tumors containing these histologies, or low-grade/borderline ovarian tumors
- Previous diagnosis of noninfectious interstitial lung disease, including noninfectious pneumonitis
- Prior anticancer therapy for current cancer, except one cycle of single agent carboplatin
- History of corneal transplantation
- Undergoing active postoperative management for refractive surgery, cataract surgery, corneal cross-linking, or related complications
- Confluent superficial punctate keratopathy not expected to improve before screening
- Active or chronic clinically significant (≥ Grade 3) corneal dystrophy
- Active ocular conditions needing ongoing treatment or monitoring, including uncontrolled glaucoma, wet age-related macular degeneration requiring injections, active diabetic retinopathy with macular edema, macular degeneration, papilledema, or high risk of retinal detachment
- Monocular vision with visual acuity worse than 20/200 or visual fields less than 20 degrees
- History of other malignancies within 3 years prior to consent, except tumors with negligible risk for metastasis or death such as controlled basal-cell carcinoma, squamous-cell carcinoma of skin, or carcinoma in situ of cervix or breast
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 61 locations
1
University of Alabama at Birmingham (UAB) Hospital /ID# 274793
Birmingham, Alabama, United States, 35294
Actively Recruiting
2
Usa Mitchell Cancer Institute /ID# 276022
Mobile, Alabama, United States, 36604
Actively Recruiting
3
University of California Los Angeles Medical Center /ID# 274566
Los Angeles, California, United States, 90095
Actively Recruiting
4
Scripps Mercy Hospital /ID# 276891
San Diego, California, United States, 92103
Actively Recruiting
5
California Pacific Medical Center /ID# 275329
San Francisco, California, United States, 94109
Actively Recruiting
6
Ridley Tree Cancer Center /ID# 275219
Santa Barbara, California, United States, 93105
Actively Recruiting
7
Danbury Hospital, Western Connecticut Health Network /ID# 274783
Danbury, Connecticut, United States, 06810
Actively Recruiting
8
Yale University School of Medicine /ID# 275794
New Haven, Connecticut, United States, 06510
Actively Recruiting
9
Norwalk Hospital /ID# 274561
Norwalk, Connecticut, United States, 06856
Actively Recruiting
10
Jupiter Medical Center /ID# 276616
Jupiter, Florida, United States, 33458
Actively Recruiting
11
Mount Sinai Medical Center /ID# 274868
Miami, Florida, United States, 33140
Actively Recruiting
12
Rush Md Anderson Cancer Center /ID# 274926
Chicago, Illinois, United States, 60607
Actively Recruiting
13
OSF St. Francis Medical Center /ID# 274752
Peoria, Illinois, United States, 61637-0001
Actively Recruiting
14
Parkview Research Center /ID# 274338
Fort Wayne, Indiana, United States, 46845
Actively Recruiting
15
Indiana University Melvin and Bren Simon Cancer Center /ID# 275492
Indianapolis, Indiana, United States, 46202
Actively Recruiting
16
Baptist Health Lexington /ID# 275218
Lexington, Kentucky, United States, 40503
Actively Recruiting
17
Norton Cancer Institute - St. Matthews /ID# 276173
Louisville, Kentucky, United States, 40207
Actively Recruiting
18
Women'S Cancer Care /ID# 276469
Covington, Louisiana, United States, 70433
Actively Recruiting
19
University Medical Center New Orleans /ID# 274755
New Orleans, Louisiana, United States, 70112
Actively Recruiting
20
Trials 365 /ID# 274310
Shreveport, Louisiana, United States, 71103
Actively Recruiting
21
University of Maryland, Baltimore /ID# 275308
Baltimore, Maryland, United States, 21201
Actively Recruiting
22
Holy Cross Hospital /ID# 275872
Silver Spring, Maryland, United States, 20910
Actively Recruiting
23
University of Minnesota - Minneapolis /ID# 275718
Minneapolis, Minnesota, United States, 55455-0341
Actively Recruiting
24
Metro Minnesota Community Oncology Research Consortium (MMCORC) /ID# 274780
Saint Louis Park, Minnesota, United States, 55416
Actively Recruiting
25
Cox Medical Center South /ID# 274826
Springfield, Missouri, United States, 65807
Actively Recruiting
26
The Center Of Hope /ID# 274313
Reno, Nevada, United States, 89511
Actively Recruiting
27
Dartmouth-Hitchcock Medical Center /ID# 274676
Lebanon, New Hampshire, United States, 03756
Actively Recruiting
28
Rutgers Cancer Institute of New Jersey /ID# 274358
New Brunswick, New Jersey, United States, 08901
Actively Recruiting
29
Holy Name Medical Center /ID# 276240
Teaneck, New Jersey, United States, 07666
Actively Recruiting
30
Optimum Clinical Research Group /ID# 274583
Albuquerque, New Mexico, United States, 87109
Actively Recruiting
31
Imbert Cancer Center /ID# 275634
Bay Shore, New York, United States, 11706
Actively Recruiting
32
Northwell Health Cancer Institute At Huntington /ID# 276814
Greenlawn, New York, United States, 11740
Actively Recruiting
33
Northwell Health Center for Advanced Medicine. /ID# 275641
Lake Success, New York, United States, 11042
Actively Recruiting
34
Northwell Health Queens Cancer Center /ID# 274850
Rego Park, New York, United States, 11374
Actively Recruiting
35
University of North Carolina Medical Center /ID# 275307
Chapel Hill, North Carolina, United States, 27514
Actively Recruiting
36
East Carolina University - Brody School of Medicine /ID# 275770
Greenville, North Carolina, United States, 27834
Actively Recruiting
37
Atrium Health Wake Forest Baptist Medical Center /ID# 276952
Winston-Salem, North Carolina, United States, 27157
Actively Recruiting
38
Sanford Fargo Medical Center - Fargo /ID# 275489
Fargo, North Dakota, United States, 58102
Actively Recruiting
39
Cleveland Clinic - Cleveland /ID# 276133
Cleveland, Ohio, United States, 44195
Actively Recruiting
40
Cleveland Clinic - Cleveland /ID# 278273
Cleveland, Ohio, United States, 44195
Actively Recruiting
41
Cleveland Clinic - Cleveland /ID# 278274
Cleveland, Ohio, United States, 44195
Actively Recruiting
42
The Mark H Zangmeister Center /ID# 275106
Columbus, Ohio, United States, 43219
Actively Recruiting
43
Oncology Associates of Oregon, P.C. /ID# 275006
Eugene, Oregon, United States, 97401
Actively Recruiting
44
Northwest Cancer Specialists /ID# 275101
Portland, Oregon, United States, 97227-1800
Actively Recruiting
45
St. Lukes University Hospital /ID# 274362
Bethlehem, Pennsylvania, United States, 18015
Actively Recruiting
46
University of Pennsylvania /ID# 275612
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
47
Women & Infants Hospital /ID# 274716
Providence, Rhode Island, United States, 02905
Actively Recruiting
48
Sanford Cancer Center /ID# 274901
Sioux Falls, South Dakota, United States, 57104
Actively Recruiting
49
Avera Cancer Institute - Sioux Falls /ID# 276226
Sioux Falls, South Dakota, United States, 57105
Actively Recruiting
50
Texas Oncology - Austin Central /ID# 275046
Austin, Texas, United States, 78731
Actively Recruiting
51
Texas Oncology - Fort Worth Cancer Center /ID# 275043
Fort Worth, Texas, United States, 76104
Actively Recruiting
52
Houston Methodist Hospital /ID# 274568
Houston, Texas, United States, 77030
Actively Recruiting
53
Texas Oncology - San Antonio Medical Center - Research Drive /ID# 275090
San Antonio, Texas, United States, 78240
Actively Recruiting
54
Texas Oncology - The Woodlands /ID# 275015
The Woodlands, Texas, United States, 77380
Actively Recruiting
55
Texas Oncology - Northeast Texas /ID# 275057
Tyler, Texas, United States, 75702
Actively Recruiting
56
UVA Health University Hospital /ID# 275309
Charlottesville, Virginia, United States, 22903
Actively Recruiting
57
Inova Schar Cancer Institute - Fairfax - Innovation Park Drive /ID# 276456
Fairfax, Virginia, United States, 22031
Actively Recruiting
58
Virginia Oncology Associates- Norfolk (Brock) /ID# 275227
Norfolk, Virginia, United States, 23502-2800
Actively Recruiting
59
Carilion Roanoke Memorial Hospital /ID# 274684
Roanoke, Virginia, United States, 24014
Actively Recruiting
60
Providence Sacred Heart Medical Center & Children'S Hospital /ID# 274585
Spokane, Washington, United States, 99204
Actively Recruiting
61
West Virginia University School of Medicine /ID# 274556
Morgantown, West Virginia, United States, 26506
Actively Recruiting
Research Team
A
ABBVIE CALL CENTER
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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