Actively Recruiting

Phase 1
Age: 18Years +
All Genders
NCT06153251

A Study to Assess BMS-986453 in Participants With Relapsed and/or Refractory Multiple Myeloma

Led by Juno Therapeutics, Inc., a Bristol-Myers Squibb Company · Updated on 2026-03-18

187

Participants Needed

19

Research Sites

327 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The purpose of this study is to assess BMS-986453 in participants with relapsed and/or refractory multiple myeloma (RRMM).

CONDITIONS

Official Title

A Study to Assess BMS-986453 in Participants With Relapsed and/or Refractory Multiple Myeloma

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Diagnosis of multiple myeloma with relapsed and/or refractory disease
  • Confirmed progressive disease on or within 12 months of last anti-myeloma treatment
  • Previous antimyeloma therapy including a proteasome inhibitor and an immunomodulatory agent
  • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
  • Adequate organ function
Not Eligible

You will not qualify if you...

  • Known active or history of central nervous system involvement of multiple myeloma
  • Active or history of plasma cell leukemia, Waldenstrom's macroglobulinemia, POEMS syndrome, or clinically significant amyloidosis
  • History or presence of significant CNS conditions such as seizure disorder, aphasia, stroke, severe brain injury, dementia, Parkinson's disease, cerebellar disease, or active psychosis
  • Other protocol-defined inclusion/exclusion criteria

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 19 locations

1

University of Alabama at Birmingham

Birmingham, Alabama, United States, 35294

Actively Recruiting

2

City of Hope Comprehensive Cancer Center

Duarte, California, United States, 91010

Actively Recruiting

3

UCSF Helen Diller Medical Center at Parnassus Heights

San Francisco, California, United States, 94143

Actively Recruiting

4

Stanford University Medical Center

Stanford, California, United States, 94305

Actively Recruiting

5

Colorado Blood Cancer Institute

Denver, Colorado, United States, 80218

Actively Recruiting

6

Yale Cancer Center

New Haven, Connecticut, United States, 06520

Actively Recruiting

7

Moffitt Cancer Center

Tampa, Florida, United States, 33612

Actively Recruiting

8

Dana-Farber Cancer Institute

Boston, Massachusetts, United States, 02215

Actively Recruiting

9

Icahn School of Medicine at Mount Sinai

New York, New York, United States, 10029

Actively Recruiting

10

Memorial Sloan Kettering Cancer Center

New York, New York, United States, 10065

Actively Recruiting

11

Local Institution - 0008

Nashville, Tennessee, United States, 37203

Not Yet Recruiting

12

Tennessee Oncology

Nashville, Tennessee, United States, 37203

Actively Recruiting

13

Swedish Medical Center

Seattle, Washington, United States, 98104

Actively Recruiting

14

Hôpital Saint-Louis

Paris, France, 75010

Actively Recruiting

15

Universitaetsklinikum Koeln

Cologne, Germany, 50937

Actively Recruiting

16

Universitaetsklinikum Heidelberg

Heidelberg, Germany, D-69120

Actively Recruiting

17

Universitaetsklinikum Wuerzburg

Würzburg, Germany, 97080

Actively Recruiting

18

Clinica Universidad de Navarra

Pamplona, Navarre, Spain, 31008

Actively Recruiting

19

Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca

Salamanca, Spain, 37007

Actively Recruiting

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Research Team

B

BMS Clinical Trials Contact Center www.BMSClinicalTrials.com

CONTACT

F

First line of the email MUST contain NCT # and Site #.

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

1

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