Actively Recruiting
A Study to Assess Disease Activity in Adult Participants With Axial Spondyloarthritis Who Receive Upadacitinib in a Real-world Setting
Led by AbbVie · Updated on 2026-05-13
352
Participants Needed
72
Research Sites
236 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Axial spondyloarthritis (axSpA) is an immune-mediated inflammatory disease primarily affecting the axial skeleton. The most frequent axSpA symptom is chronic, often inflammatory back pain that might be difficult to distinguish from other causes of chronic back pain. Many participants report persistent pain, including back pain, which impacts disease activity and and impairs quality of life while evoking typical disease burden such as sleep disturbance, social isolation, loss of productivity, as well as anxiety and depression. This study will assess the real-world effectiveness of upadacitinib on early and sustained disease control, and the association between pain and clinical/patient-reported outcomes in axSpA participants. Upadacitinib is being developed for the treatment of axSpA. Approximately 352 adult participants with active axSpA will be enrolled in Germany. Participants will receive oral upadacitinib tablets as prescribed by the physician prior to enrolling in this study in accordance with the terms of the local marketing authorization and professional and reimbursement guidelines with regards to dose, population and indication. The overall duration of the study is approximately 52 weeks. There may be a higher burden for participants in this study compared to usual standard of care due to study procedures. Participants will attend regular visits per routine clinical practice. The effect of the treatment will be checked by medical assessments, checking for side effects, and questionnaires.
CONDITIONS
Official Title
A Study to Assess Disease Activity in Adult Participants With Axial Spondyloarthritis Who Receive Upadacitinib in a Real-world Setting
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical diagnosis of axial spondyloarthritis as determined by a physician
- Decision to treat with upadacitinib made before study recruitment
- Upadacitinib prescribed according to local approval guidelines
You will not qualify if you...
- Previous use of any Janus kinase (JAK) inhibitor including upadacitinib, tofacitinib, baricitinib, or filgotinib
- Diagnosis of primary fibromyalgia according to physician judgment
- Participation in another investigational drug clinical trial currently or within the last 30 days or five half-lives of that drug
- Inability to be treated with upadacitinib according to local treatment guidelines
AI-Screening
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Trial Site Locations
Total: 72 locations
1
ACURA Rheumazentrum Baden-Bade /ID# 249751
Baden-Baden, Baden-Wurttemberg, Germany, 76530
Completed
2
Heilig, Heidelberg, DE /ID# 240492
Heidelberg, Baden-Wurttemberg, Germany, 69120
Active, Not Recruiting
3
Rheumatologische Schwerpunktpraxis /ID# 245392
Stuttgart, Baden-Wurttemberg, Germany, 70372
Completed
4
Praxis Dr. Haas /ID# 242982
Tübingen, Baden-Wurttemberg, Germany, 72072
Active, Not Recruiting
5
Praxis Dr. Rinaldi /ID# 242984
Ulm, Baden-Wurttemberg, Germany, 89073
Active, Not Recruiting
6
Praxis K. Pagel /ID# 240490
Hoppegarten, Brandenburg, Germany, 15366
Active, Not Recruiting
7
Rheumahaus Studien GbR, Potsdam, DE /ID# 245231
Potsdam, Brandenburg, Germany, 14467
Active, Not Recruiting
8
Praxis Dr. Sabine Reckert /ID# 245142
Potsdam, Brandenburg, Germany, 14469
Completed
9
Fachpraxis fuer Rheumatologie und Osteologie /ID# 243358
Bruchhausen-Vilsen, Lower Saxony, Germany, 27305
Active, Not Recruiting
10
Stille, Hanover, DE /ID# 252222
Hanover, Lower Saxony, Germany, 30161
Active, Not Recruiting
11
Praxis. F. Bigdeli-Wilshusen /ID# 272904
Hanover, Lower Saxony, Germany, 30173
Active, Not Recruiting
12
Medizinische Hochschule Hannover /ID# 262814
Hanover, Lower Saxony, Germany, 30625
Active, Not Recruiting
13
Rheumatologie Kassel /ID# 275998
Kassel, Lower Saxony, Germany, 34125
Active, Not Recruiting
14
Krankenhaus Porz am Rhein /ID# 243765
Cologne, North Rhine-Westphalia, Germany, 51149
Active, Not Recruiting
15
Rheumazentrum Ruhrgebiet /ID# 240460
Herne, North Rhine-Westphalia, Germany, 44649
Active, Not Recruiting
16
Beyer, Kaiserslautern, DE /ID# 240444
Kaiserslautern, Rhineland-Palatinate, Germany, 67659
Active, Not Recruiting
17
Krankenhaus der Barmherzigen Brüder Trier /ID# 240524
Trier, Rhineland-Palatinate, Germany, 54292
Active, Not Recruiting
18
Praxis Bernd Mueller /ID# 240488
Homburg, Saarland, Germany, 66424
Completed
19
Rheumapraxis Dr. Prothmann /ID# 240671
Püttlingen, Saarland, Germany, 66346
Active, Not Recruiting
20
Medizinischen Versorgungszentrums Agilomed /ID# 240481
Chemnitz, Saxony, Germany, 09130
Completed
21
Rheumatologisches Medizinisches Versorgungszentrum Dresden /ID# 240516
Dresden, Saxony, Germany, 01109
Completed
22
Hamann & Teich & Boche,Leipzig /ID# 240445
Leipzig, Saxony, Germany, 04109
Active, Not Recruiting
23
Praxis internistische Rheumatologie /ID# 240515
Leipzig, Saxony, Germany, 04129
Active, Not Recruiting
24
Praxis Dr. Liebhaber /ID# 240480
Halle, Saxony-Anhalt, Germany, 06128
Completed
25
Aurich & Sieburg, Magdeburg /ID# 240518
Magdeburg, Saxony-Anhalt, Germany, 39104
Active, Not Recruiting
26
Rheumatologische Facharztpraxis - Naumburg (Saale) /ID# 240477
Naumburg, Saxony-Anhalt, Germany, 06618
Active, Not Recruiting
27
Rheumatologische Praxis Dr. Jochen Walter /ID# 250263
Rendsburg, Schleswig-Holstein, Germany, 24768
Active, Not Recruiting
28
MVZ Ambulantes Rheumazentrum Erfurt /ID# 244448
Erfurt, Thuringia, Germany, 99096
Active, Not Recruiting
29
Rheumapraxis Weimar /ID# 268387
Weimar, Thuringia, Germany, 99427
Active, Not Recruiting
30
Kupka & Kupka, Altenburg, DE /ID# 240479
Altenburg, Germany, 04600
Active, Not Recruiting
31
Marycz, Amberg, DE /ID# 240483
Amberg, Germany, 92224
Active, Not Recruiting
32
Rheumapraxis am Webereck /ID# 240454
Augsburg, Germany, 86157
Active, Not Recruiting
33
Praxis S. Bresgulewski /ID# 240662
Bad Bertrich, Germany, 56864
Active, Not Recruiting
34
Kerckhoff Klinik /ID# 252219
Bad Nauheim, Germany, 61231
Active, Not Recruiting
35
Rheumapraxis Berlin /ID# 242987
Berlin, Germany, 12435
Active, Not Recruiting
36
Praxis Dr. med. Angela Seifert /ID# 245107
Berlin, Germany, 12555
Completed
37
Praxis Dr. Silke Zinke /ID# 240526
Berlin, Germany, 13055
Active, Not Recruiting
38
Krankenhaus Waldfriede /ID# 268389
Berlin, Germany, 14163
Completed
39
Eisterhues, Braunschweig, DE /ID# 239438
Braunschweig, Germany, 38100
Completed
40
MVZ Herzogin Elisabeth Hospital /ID# 267983
Braunschweig, Germany, 38114
Active, Not Recruiting
41
Dr. Walberer /ID# 249752
Burglengenfeld, Germany, 93133
Active, Not Recruiting
42
Private Practice - Dr. Sebastian Schuh /ID# 240498
Coburg, Germany, 96450
Completed
43
Dres. Karger/Baerlecken /ID# 240442
Cologne, Germany, 50996
Active, Not Recruiting
44
MVZ-Medizinisches Versorgungszentrum Daun GmbH /ID# 254839
Daun, Germany, 54550
Completed
45
Kreiskrankenhaus Demmin /ID# 240451
Demmin, Germany, 17109
Active, Not Recruiting
46
Praxis Dilltal /ID# 240520
Ehringshausen, Germany, 35630
Active, Not Recruiting
47
Private Practice - Dr. Daniel Bestler /ID# 251860
Erfurt, Germany, 99096
Active, Not Recruiting
48
Michael Mueller, Freiberg, DE /ID# 240489
Freiberg, Germany, 09599
Active, Not Recruiting
49
Praxis Dres. Sensse/Sensse /ID# 240517
Gifhorn, Germany, 38518
Active, Not Recruiting
50
Private Practice - Dr. Hauke E. Heintz /ID# 254037
Hamburg, Germany, 22391
Active, Not Recruiting
51
Dres. Weinhardt/Knobel/Doepfer /ID# 248195
Hamburg, Germany, 22523
Active, Not Recruiting
52
Zentrum fuer Rheumatologie und Schmerzmedizin /ID# 244370
Hanover, Germany, 30159
Active, Not Recruiting
53
Wernicke, Hohen Neuendorf, DE /ID# 250626
Hohen Neuendorf, Germany, 16540
Active, Not Recruiting
54
Kremers, Juelich, DE /ID# 243357
Jülich, Germany, 52428
Active, Not Recruiting
55
Dr. Bolze, Ludwigshafen, DE /ID# 251012
Ludwigshafen, Germany, 67069
Active, Not Recruiting
56
Praxis Dr. Annekatrin Rossbach /ID# 240495
Mansfeld / Großörner, Germany, 06343
Completed
57
Harmuth, Marktredwitz, DE /ID# 240455
Marktredwitz, Germany, 95615
Active, Not Recruiting
58
RHIO Forschungsinstitut /ID# 240525
Meerbusch, Germany, 40668
Active, Not Recruiting
59
Prof-med-stud.de /ID# 240458
Munich, Germany, 80935
Active, Not Recruiting
60
Praxis Dr. med Thilo Klopsch /ID# 240461
Neubrandenburg, Germany, 17033
Active, Not Recruiting
61
Praxis Hein & Gess /ID# 240456
Nienburg, Germany, 31582
Active, Not Recruiting
62
MVZ für Rheumatologie Dr. M. Welcker /ID# 240521
Planegg, Germany, 82152
Active, Not Recruiting
63
Baumann & Lang, Plauen, DE /ID# 244369
Plauen, Germany, 08523
Active, Not Recruiting
64
Rheumazentrum Ratingen /ID# 240465
Ratingen, Germany, 40882
Completed
65
Melzer, Seesen, DE /ID# 240484
Seesen, Germany, 38723
Active, Not Recruiting
66
Barmherzige Bruder MVZ Klinikum Straubing GmbH /ID# 240523
Straubing, Germany, 94315
Active, Not Recruiting
67
Rheumathologie Ulm /ID# 240494
Ulm, Germany, 89073
Completed
68
Praxis F. Schattenberg /ID# 257646
Waren, Germany, 17192
Active, Not Recruiting
69
Krankenhaus St. Josef /ID# 249747
Wuppertal, Germany, 42105
Active, Not Recruiting
70
Praxis Barmen /ID# 240449
Wuppertal, Germany, 42285
Completed
71
Praxis Barmen /ID# 277515
Wuppertal, Germany, 42285
Actively Recruiting
72
Fricke-Wagner, Zwickau, DE /ID# 240452
Zwickau, Germany, 08060
Active, Not Recruiting
Research Team
M
Medical Information Germany
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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