Actively Recruiting
A Study to Assess the Efficacy and Safety of Empasiprubart Versus IVIg in Adults With Multifocal Motor Neuropathy
Led by argenx · Updated on 2026-03-13
115
Participants Needed
109
Research Sites
258 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The main purpose of this study is to compare empasiprubart and IVIg in adult patients with MMN. The study consists of a double-blinded part A (empasiprubart, IVIg) and an open-label part B (empasiprubart). The maximum study duration for participants is up to 49 months. More information can be found here: https://clinicaltrials.argenx.com/empassion
CONDITIONS
Official Title
A Study to Assess the Efficacy and Safety of Empasiprubart Versus IVIg in Adults With Multifocal Motor Neuropathy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- At least 18 years old and meets local legal age for clinical studies
- Confirmed diagnosis of definite or probable MMN based on EFNS/PNS 2010 guidelines
- Has responded to IVIg treatment within the past 5 years
- Currently receiving IVIg every 2, 3, 4, or 5 weeks at a dose of 0.4 to 2.0 g/kg per cycle
- Maintained a stable IVIg treatment regimen (no change in frequency or dose >10%) for at least 8 weeks before screening, or 10 weeks if on a 5-week IVIg cycle
- Minimum weekly IVIg dose of 0.125 g/kg or higher
- Documented immunization against N meningitidis and S pneumoniae within 5 years or willing to receive immunization at least 14 days before first study drug
You will not qualify if you...
- Presence of known autoimmune diseases other than the study indication (e.g., SLE) or any medical condition that could interfere with study results or increase risk
- Signs or symptoms suggesting other neuropathies besides MMN, such as motor neuron disease or other inflammatory neuropathies
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 109 locations
1
HonorHealth Neurology - Bob Bove Neuroscience Institute - Neurology
Scottsdale, Arizona, United States, 85251
Active, Not Recruiting
2
The Neurology Group
Pomona, California, United States, 91767
Active, Not Recruiting
3
Samir Macwan, M.D., Inc.
Rancho Mirage, California, United States, 92270
Active, Not Recruiting
4
University of California San Francisco
San Francisco, California, United States, 94143
Active, Not Recruiting
5
University of Colorado - Anschutz Cancer Pavilion (Neuro Onc Clinic)
Aurora, Colorado, United States, 80045
Active, Not Recruiting
6
Yale University School of Medicine
New Haven, Connecticut, United States, 06511
Active, Not Recruiting
7
Medstar Health Research Institute
Washington D.C., District of Columbia, United States, 20010
Active, Not Recruiting
8
EZR Research LLC
Boca Raton, Florida, United States, 33486
Active, Not Recruiting
9
Healthcare Innovations Institute, LLC
Coral Springs, Florida, United States, 33067
Active, Not Recruiting
10
University of Miami Miller School of Medicine
Miami, Florida, United States, 33136
Active, Not Recruiting
11
University of South Florida
Tampa, Florida, United States, 33612
Active, Not Recruiting
12
Northwestern University
Chicago, Illinois, United States, 60611
Active, Not Recruiting
13
Indiana University Health Neuroscience Center
Indianapolis, Indiana, United States, 46202
Active, Not Recruiting
14
University of Kansas Medical Center
Fairway, Kansas, United States, 66205
Active, Not Recruiting
15
Perelman Center for Advanced Medicine
Columbia, Maryland, United States, 21044
Active, Not Recruiting
16
UC Irvine - MDA ALS and Neuromuscular Center
Columbia, Maryland, United States, 21044
Active, Not Recruiting
17
University of Minnesota
Minneapolis, Minnesota, United States, 55414
Active, Not Recruiting
18
Dent Neurologic Institute Amherst
Amherst, New York, United States, 14226
Active, Not Recruiting
19
Columbia University Medical Center
New York, New York, United States, 10032
Active, Not Recruiting
20
University of North Carolina at Chapel Hill
Morrisville, North Carolina, United States, 27560
Active, Not Recruiting
21
The Cleveland Clinic Foundation
Cleveland, Ohio, United States, 44195
Active, Not Recruiting
22
Oregon Health and Science University
Portland, Oregon, United States, 97239
Active, Not Recruiting
23
National Neuromuscular Research Institute
Austin, Texas, United States, 78759-8402
Active, Not Recruiting
24
NeuroCarePlus
Houston, Texas, United States, 77094
Active, Not Recruiting
25
Royal Melbourne Hospital
Parkville, Australia, 3050
Active, Not Recruiting
26
Gold Coast University Hospital
Southport, Australia, 4215
Active, Not Recruiting
27
Brain and Mind Center
Sydney, Australia, 2609
Active, Not Recruiting
28
Princess Alexandra Hospital
Woolloongabba, Australia, 4102
Active, Not Recruiting
29
Universitätsklinikum AKH Wien
Vienna, Austria, 1090
Active, Not Recruiting
30
UZ Antwerpen
Edegem, Belgium, 2650
Active, Not Recruiting
31
UZ Leuven
Leuven, Belgium, 3000
Active, Not Recruiting
32
Hôpital de la Citadelle
Liège, Belgium, 4000
Active, Not Recruiting
33
Hospital Das Clinicas da Faculdade de Medicina de Ribeirão Preto
Ribeirão Preto, Brazil, 14051
Active, Not Recruiting
34
Sociedade de Ensino Superior Estacio de Sa Ltda
Rio de Janeiro, Brazil, 22620-172
Active, Not Recruiting
35
Escola Bahiana de Medicina e Saude Publica
Salvador, Brazil, 40290-000
Active, Not Recruiting
36
PSEG Centro de Pesquisa Clínica
São Paulo, Brazil, 04038-002
Active, Not Recruiting
37
Neuro-Outaouais Clinic
Gatineau, Canada, J8Y 1W2
Active, Not Recruiting
38
London Health Sciences Centre
London, Canada, N6A 5A5
Active, Not Recruiting
39
St. Paul's Neurology Associates
Vancouver, Canada, V6Z 2H2
Active, Not Recruiting
40
Huashan Hospital Fudan University
Shanghai, China, 200040
Active, Not Recruiting
41
Fakultni nemocnice Brno
Brno, Czechia, 625 00
Active, Not Recruiting
42
Fakultni nemocnice Hradec Kralove
Hradec Králové, Czechia, 500 05
Active, Not Recruiting
43
Vseobecna Fakultni Nemocnice V Praze
Prague, Czechia, 128 08
Active, Not Recruiting
44
Aarhus Universitetshospital
Aarhus, Denmark, 8200
Active, Not Recruiting
45
Rigshospitalet-Inge Lehmanns Vej 8
Copenhagen, Denmark, 2100
Active, Not Recruiting
46
CHU de Bordeaux - Hôpital Pellegrin
Bordeaux, France, 33000
Active, Not Recruiting
47
CHU de Brest - Hôpital La Cavale Blanche
Brest, France, 29609
Active, Not Recruiting
48
Hospices Civils de Lyon - Hôpital Pierre Wertheimer
Bron, France, 69500
Active, Not Recruiting
49
AP-HP - Hôpital Bicêtre
Le Kremlin-Bicêtre, France, 94270
Active, Not Recruiting
50
Hôpital Roger Salengro
Lille, France, 59000
Active, Not Recruiting
51
CHU Limoges - Dupuytren 1
Limoges, France, 87042
Active, Not Recruiting
52
AP-HM- Hôpital de La Timone
Marseille, France, 13005
Active, Not Recruiting
53
AP-HM- Hôpital de La Timone
Marseille, France, 13385
Active, Not Recruiting
54
CHU de Nice-Hôpital Pasteur
Nice, France, 6001
Active, Not Recruiting
55
AP-HP - Hôpital de la Pitié Salpétrière
Paris, France, 75013
Active, Not Recruiting
56
CHU de Strasbourg - Hôpital de Hautepierre
Strasbourg, France, 67200
Active, Not Recruiting
57
Universitätsklinikum Essen
Essen, Germany, 45147
Active, Not Recruiting
58
Universität Georg August
Göttingen, Germany, 37075
Active, Not Recruiting
59
Universitätsklinikum Schleswig-Holstein - Campus Lübeck
Lübeck, Germany, 23538
Active, Not Recruiting
60
Universitätsklinikum Münster
Münster, Germany, 48149
Active, Not Recruiting
61
Alexianer - MVZ St. Josefs-Krankenhaus Potsdam GmbH
Potsdam, Germany, 14471
Active, Not Recruiting
62
Universitätsklinikum Würzburg
Würzburg, Germany, 97080
Active, Not Recruiting
63
University General Hospital ''ATTIKON'' - General Hospital of West Attica H AGIA VARVARA
Chaïdári, Greece, 124 62
Active, Not Recruiting
64
AHEPA University General Hospital of Thessaloniki
Thessaloniki, Greece, 546 36
Active, Not Recruiting
65
Azienda Ospedaliera Universitaria Careggi
Florence, Italy, 50134
Active, Not Recruiting
66
Ospedale Policlinico San Martino IRCCS
Genova, Italy, 16132
Active, Not Recruiting
67
Fondazione Serena Onlus - Centro Clinico NeMO Brescia
Gussago, Italy, 25064
Active, Not Recruiting
68
Az. Ospedaliera Universitaria Policlinico G. Martino
Messina, Italy, 98124
Active, Not Recruiting
69
Ospedale San Raffaele S.r.l.
Milan, Italy, 20132
Active, Not Recruiting
70
Azienda Ospedaliero-Universitaria San Luigi Gonzaga
Milan, Italy, 20133
Active, Not Recruiting
71
Azienda Ospedaliero-Universitaria Sant'Andrea
Roma, Italy, 00189
Active, Not Recruiting
72
Fondazione PTV Policlinico Tor Vergata
Roma, Italy, 133
Active, Not Recruiting
73
IRCCS Istituto Clinico Humanitas
Rozzano, Italy, 20089
Active, Not Recruiting
74
Juntendo University Hospital
Bunkyō City, Japan, 113-8431
Active, Not Recruiting
75
Institute of Science Tokyo Hospital
Bunkyō City, Japan, 113-8519
Active, Not Recruiting
76
Chiba University Hospital
Chūōku, Japan, 260-8677
Active, Not Recruiting
77
National Center of Neurology and Psychiatry
Kodaira, Japan, 187-8502
Active, Not Recruiting
78
Nagoya University Hospital
Nagoya, Japan, 4668560
Active, Not Recruiting
79
Teikyo University Hospital
tabashi City, Japan, 173-8606
Actively Recruiting
80
Yamaguchi University Hospital
Ube, Japan, 755-0067
Active, Not Recruiting
81
Pauls Stradins Clinical University Hospital
Riga, Latvia, LV-1002
Active, Not Recruiting
82
Hospital of Lithuanian University of Health Sciences Kauno klinikos
Kaunas, Lithuania, 50161
Active, Not Recruiting
83
Amsterdam UMC
Amsterdam, Netherlands, 1105 AZ
Active, Not Recruiting
84
Oslo Universitetssykehus HF, Ullevål
Oslo, Norway, 0450
Active, Not Recruiting
85
MICS Centrum Medyczne Bydgoszcz
Bydgoszcz, Poland, 85-065
Active, Not Recruiting
86
Centrum Medyczne Neurologia Slaska
Katowice, Poland, 40-689
Active, Not Recruiting
87
SP ZOZ Szpital Uniwersytecki w Krakowie
Krakow, Poland, 30-688
Active, Not Recruiting
88
Galen Clinic -- Lublin
Lublin, Poland, 20--64
Active, Not Recruiting
89
UCK WUM, Centralny Szpital Kliniczny
Warsaw, Poland, 02-097
Active, Not Recruiting
90
ULS de Santo António, EPE - Hospital de Santo António
Porto, Portugal, 4099-001
Active, Not Recruiting
91
University Clinical Center of Serbia
Belgrade, Serbia, 11000
Active, Not Recruiting
92
Univerzitna nemocnica Bratislava
Bratislava, Slovakia, 821 01
Active, Not Recruiting
93
Univerzitna nemocnica MARTIN
Martin, Slovakia, 036 59
Active, Not Recruiting
94
University Medical Centre Ljubljana
Ljubljana, Slovenia, 1000
Active, Not Recruiting
95
Hospital General Universitario Dr. Balmis
Alicante, Spain, 03010
Active, Not Recruiting
96
Hospital Universitario Germans Trias i Pujol
Badalona, Spain, 08916
Active, Not Recruiting
97
Hospital Universitario Vall d'Hebron
Barcelona, Spain, 08035
Active, Not Recruiting
98
Hospital de La Santa Creu i Sant Pau
Barcelona, Spain, 08041
Active, Not Recruiting
99
Hospital Universitario de Bellvitge
Barcelona, Spain, 08907
Active, Not Recruiting
100
Hospital Clinico San Carlos
Madrid, Spain, 28039
Active, Not Recruiting
101
Hospital Universitario de Basurto
Madrid, Spain, 48013
Active, Not Recruiting
102
Hospital Quironsalud Malaga
Málaga, Spain, 29004
Active, Not Recruiting
103
Hospital Universitario de Donostia
San Sebastián, Spain, 8035
Active, Not Recruiting
104
Inselspital - Universitätsspital Bern
Bern, Switzerland, 3010
Active, Not Recruiting
105
Queen Elizabeth University Hospital
Glasgow, United Kingdom, G51 4TF
Active, Not Recruiting
106
John Radcliffe Hospital
Oxford, United Kingdom, OX3 7LE
Active, Not Recruiting
107
Salford Royal Hospital
Salford, United Kingdom, M6 8HD
Active, Not Recruiting
108
Royal Hallamshire Hospital
Sheffield, United Kingdom, S10 2JF
Active, Not Recruiting
109
Musgrove Park Hospital
Taunton, United Kingdom, TA1 5DA
Active, Not Recruiting
Research Team
S
Sabine Coppieters, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here