Actively Recruiting
Study to Assess the Efficacy and Safety of Rina-S Compared to Treatment of Investigator's Choice in Participants With Endometrial Cancer
Led by Genmab · Updated on 2026-05-06
660
Participants Needed
74
Research Sites
204 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to compare how well Rina-S (GEN1184) works compared to treatment of physician's choice (paclitaxel or doxorubicin) that are considered standard medical care for the treatment of recurrent or progressive endometrial cancer (EC) following prior therapy. There is an equal (50:50) chance of getting either Rina-S or a chemotherapy agent as treatment in this study. The study duration will be approximately 3 years. The treatment duration will be different for every participant, but an average of 4 to 6 months is expected. All participants will receive active drug; no one will be given placebo. Participation in the study will require visits to the study site(s).
CONDITIONS
Official Title
Study to Assess the Efficacy and Safety of Rina-S Compared to Treatment of Investigator's Choice in Participants With Endometrial Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants must be female with histologically or cytologically confirmed recurrent or progressive endometrial cancer, excluding neuroendocrine tumors, carcinosarcoma, or endometrial sarcoma
- Must have received 1 to 3 prior lines of therapy, including prior platinum-based chemotherapy and PD(L)-1 inhibitor therapy, either separately or in combination
- If the tumor recurred more than 12 months after platinum chemotherapy, additional platinum-based treatment is required unless ineligible, with documented reason
- Prior induction plus maintenance therapy counts as one line of therapy
- Hormonal therapy alone without chemotherapy is not counted as a separate line
- Therapy changes due to toxicity without progression are considered part of the same line
- Must have radiographic progression on or after the most recent therapy
You will not qualify if you...
- Prior treatment with an antibody-drug conjugate containing a topoisomerase 1 inhibitor
- Past or current malignancy other than endometrial cancer unless cured for 3 or more years or considered low risk
- Known active central nervous system metastases or carcinomatous meningitis, unless previously treated and stable for at least 4 weeks without corticosteroids or anticonvulsants for 7 days
- Hospitalization or symptoms from gastrointestinal obstruction recently or evidence of obstruction at screening
- Current need for parenteral nutrition unless approved by study medical monitor
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 74 locations
1
MedStar Washington Hospital
Washington D.C., District of Columbia, United States, 20010
Actively Recruiting
2
SMH - Sarasota - Main Campus
Sarasota, Florida, United States, 34239
Actively Recruiting
3
Women's Care - 9th Ave
St. Petersburg, Florida, United States, 33713
Actively Recruiting
4
Emory Winship Cancer Inst.
Atlanta, Georgia, United States, 30308
Actively Recruiting
5
Emory Winship Cancer Inst.
Atlanta, Georgia, United States, 30322
Actively Recruiting
6
Emory Winship Cancer Inst./Emory Decatur Hospital
Decatur, Georgia, United States, 30033
Actively Recruiting
7
Trials365, LLC
Shreveport, Louisiana, United States, 71103
Actively Recruiting
8
Sinai Hospital
Baltimore, Maryland, United States, 21215
Actively Recruiting
9
William Kahlert Reg. Can. Ctr
Westminster, Maryland, United States, 21157
Actively Recruiting
10
USOR - Minnesota Oncology-Coon Rapids Clinic
Coon Rapids, Minnesota, United States, 55433
Actively Recruiting
11
USOR - Minnesota Oncology/ Coon Rapids Clinic
Coon Rapids, Minnesota, United States, 55433
Actively Recruiting
12
USOR - Minnesota Oncology - Edina Clinic
Edina, Minnesota, United States, 55435
Actively Recruiting
13
USOR - Minnesota Oncology/Edina Clinic
Edina, Minnesota, United States, 55435
Actively Recruiting
14
USOR - Minnesota Oncology/ Maple Grove Clinic
Maple Grove, Minnesota, United States, 55369
Actively Recruiting
15
USOR - Minnesota Oncology-Maplewood Clinic
Maplewood, Minnesota, United States, 55109
Actively Recruiting
16
USOR - Minnesota Oncology/ Maplewood Clinic
Maplewood, Minnesota, United States, 55109
Actively Recruiting
17
USOR - Minnesota Oncology/ Minneapolis Clinic
Minneapolis, Minnesota, United States, 55404
Actively Recruiting
18
USOR - Minnesota Oncology
Minneapolis, Minnesota, United States, 55404
Actively Recruiting
19
USOR - Minnesota Oncology/ Woodbury Clinic
Woodbury, Minnesota, United States, 55125
Actively Recruiting
20
Washington University School of Medicine
St Louis, Missouri, United States, 63110
Actively Recruiting
21
University of Cincinnati Medical Center
Cincinnati, Ohio, United States, 45219
Actively Recruiting
22
Willamette Valley Cancer Institute and Research Center - Eugene
Eugene, Oregon, United States, 97401
Actively Recruiting
23
NW Cancer Specs. P.C.
Happy Valley, Oregon, United States, 97015
Actively Recruiting
24
USOR - NW Cancer Specs P.C.
Portland, Oregon, United States, 97227
Actively Recruiting
25
USOR - NW Cancer Specs. P.C.
Tigard, Oregon, United States, 97223
Actively Recruiting
26
TX Onc - Arlington North
Arlington, Texas, United States, 76012
Actively Recruiting
27
USOR - Texas Oncology
Austin, Texas, United States, 78731
Actively Recruiting
28
USOR - Texas Oncology
Austin, Texas, United States, 78745
Actively Recruiting
29
USOR - Texas Oncology- Austin North
Austin, Texas, United States, 78758
Actively Recruiting
30
TX Onc - Bedford
Bedford, Texas, United States, 76022
Actively Recruiting
31
TX Onc - Methodist Dallas
Dallas, Texas, United States, 75203
Actively Recruiting
32
TX Onc - Presbyterian Dallas
Dallas, Texas, United States, 75231
Actively Recruiting
33
TX Onc - Methodist Charlton
Dallas, Texas, United States, 75237
Actively Recruiting
34
TX Onc - Sammons
Dallas, Texas, United States, 75246
Actively Recruiting
35
USOR - Texas Oncology - Dallas Fort Worth (DFW)
Fort Worth, Texas, United States, 76104
Actively Recruiting
36
USOR - Texas Oncology
Harlingen, Texas, United States, 78550
Actively Recruiting
37
USOR - Texas Oncology
McAllen, Texas, United States, 78503
Actively Recruiting
38
USOR - TX Oncology - SA NE
San Antonio, Texas, United States, 78217
Actively Recruiting
39
NEXT San Antonio
San Antonio, Texas, United States, 78240
Actively Recruiting
40
USOR - Texas Oncology- Horizon Circle
Waco, Texas, United States, 76712
Actively Recruiting
41
USOR - Texas Oncology- Waco
Waco, Texas, United States, 76712
Actively Recruiting
42
USOR - Texas Oncology
Weslaco, Texas, United States, 78596
Actively Recruiting
43
USOR - NW Cancer Specs P.C.
Vancouver, Washington, United States, 98684
Actively Recruiting
44
Calvary Mater Newcastle
Waratah, New South Wales, Australia, 2298
Actively Recruiting
45
Grand Hôpital de Charleroi
Gilly, Hainaut, Belgium, 6060
Actively Recruiting
46
VITAZ
Sint-Niklaas, Sint-Niklaas, Belgium, 9100
Actively Recruiting
47
MUHC - Glen Site
Montreal, Quebec, Canada, H4A 3J1
Actively Recruiting
48
Kuopio Univ. Hospital, PSHVA
Kuopio, Northern Savonia, Finland, 70210
Actively Recruiting
49
Chiba University Hospital- Center for Outpatient
Chiba, Chiba, Japan, 260-8677
Actively Recruiting
50
Gunma Prefectural Cancer Center
Ōta, Gunma, Japan, 373-8550
Actively Recruiting
51
Iwate Medical University Hosp
Shiwa-gun, Iwate, Japan, 028-3695
Actively Recruiting
52
Kitasato University Hospital
Sagamihara-shi, Kanagawa, Japan, 252-0373
Actively Recruiting
53
Kanagawa Cancer Center
Yokohama, Kanagawa, Japan, 241-8515
Actively Recruiting
54
Mie University Hospital
Tsu, Kansai, Japan, 514-8507
Actively Recruiting
55
NUC Tohoku Univ. Hospital
Sendai, Miyagi, Japan, 980-8574
Actively Recruiting
56
Osaka International Cancer Institute - Osaka - Otemae Acti
Osaka, Osaka, Japan, 541-8567
Actively Recruiting
57
Shizuoka Cancer Center
Nagaizumi-cho, Shizuoka, Japan, 411-8777
Actively Recruiting
58
Keio University Hospital
Tokyo, Tokyo, Japan, 160-8582
Actively Recruiting
59
National Cancer Center Hospital East
Chiba, Japan, 277-8577
Actively Recruiting
60
National Hospital Organization Kyushu Cancer Center
Fukuoka, Japan, 811-1347
Actively Recruiting
61
Fukushima Medical University Hospital
Fukushima, Japan, 960-1247
Actively Recruiting
62
Hyogo Cancer Center
Hyōgo, Japan, 673-0021
Actively Recruiting
63
Niigata Cancer Center Hospital
Niigata, Japan
Actively Recruiting
64
Saitama Medical University - International Medical Center
Saitama, Japan, 350-1298
Actively Recruiting
65
Sapporo Medical University Hospital
Sapporo, Japan, 060-8543
Actively Recruiting
66
Osaka Medical and Pharmaceutical University Hospital
Takatsuki, Japan, 569-8686
Actively Recruiting
67
Cancer Institute Hospital of JFCR
Tokyo, Japan, 135-8550
Actively Recruiting
68
Yamagata University Hospital
Yamagata, Japan, 990-9585
Actively Recruiting
69
OUH Radium Hospital
Oslo, Oslofjord, Norway, 0379
Actively Recruiting
70
Haukeland University Hospital
Bergen, Vestland, Norway, NO-5021
Actively Recruiting
71
Siedleckie Centrum Onkologii
Siedlce, Masovian Voivodeship, Poland, 08-110
Actively Recruiting
72
PR Cancer Specialists
San Juan, Puerto Rico, 00917
Actively Recruiting
73
CHU A Coruña
A Coruña, La Coruña, Spain, 15006
Actively Recruiting
74
HM Sanchinarro
Madrid, Madrid, Spain, 28050
Actively Recruiting
Research Team
G
Genmab Trial Information
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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