Actively Recruiting
Study to Assess the Efficacy, Safety, and Tolerability of NOC-110 in Adults With Refractory or Unexplained Chronic Cough
Led by Nocion Therapeutics · Updated on 2026-02-17
455
Participants Needed
107
Research Sites
80 weeks
Total Duration
On this page
Sponsors
N
Nocion Therapeutics
Lead Sponsor
I
IQVIA Pty Ltd
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a phase 2b, randomized, double-blind, placebo-controlled study investigating the efficacy, safety, and tolerability of Taplucainium Inhalation Powder (NOC-110) once daily in adults with refractory or unexplained chronic cough.
CONDITIONS
Official Title
Study to Assess the Efficacy, Safety, and Tolerability of NOC-110 in Adults With Refractory or Unexplained Chronic Cough
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Refractory or unexplained chronic cough lasting 12 months or more
- Women of childbearing potential must agree to follow contraceptive guidance during the study
- Males who are not vasectomized must agree to use contraceptive methods defined in the protocol
- Able to provide informed consent
You will not qualify if you...
- Previous exposure or allergy to taplucainium or related compounds
- Current participation in another drug or device clinical study
- Participation in an acute or chronic cough investigational study within 60 days before screening
- Diagnosis of chronic obstructive pulmonary disease, bronchiectasis, unexplained pulmonary fibrosis, hemoptysis, bronchial asthma, or other pulmonary disease
- Respiratory tract infection within 4 weeks of screening or during screening
- Pregnancy, lactation, or desire to become pregnant
- Blood donation of more than 450 milliliters within 60 days before first dosing
- Alcohol or drug use disorder within the past 2 years
- Current smoker, vaper, or quit smoking within past 6 months, or smoking history over 20 pack-years
- Current opiate/opioid use or history of opiate/opioid use disorder
- History or recurrence of malignancy in the last 2 years
- Body mass index of 40 kg/m2 or higher
- Positive tests for HIV, hepatitis B, or hepatitis C
- Unable to avoid medications or treatments that affect cough during the study
- Clinically significant uncontrolled cardiovascular, respiratory, hepatic, renal, gastrointestinal, endocrine, neurological, immunological, or psychiatric disorders
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 107 locations
1
G & L Research, LLC
Foley, Alabama, United States, 36535
Actively Recruiting
2
Medical Research of Arizona
Scottsdale, Arizona, United States, 85251
Actively Recruiting
3
AMR Phoenix
Tempe, Arizona, United States, 85281
Actively Recruiting
4
Little Rock Allergy & Asthma, P.A. Clinical Research Center
Little Rock, Arkansas, United States, 72205
Actively Recruiting
5
So Cal Clinical Research
Huntington Beach, California, United States, 92647
Actively Recruiting
6
Allergy and Asthma Associates of Southern California dba Southern California Research
Laguna Niguel, California, United States, 92677
Actively Recruiting
7
Paradigm Clinical Research Centers, LLC - Modesto
Modesto, California, United States, 95355
Actively Recruiting
8
NewportNativeMD,Inc
Newport Beach, California, United States, 92663
Actively Recruiting
9
Center for Clinical Trials, LLC
Paramount, California, United States, 90723
Actively Recruiting
10
Paradigm Clinical Research Centers, LLC
Redding, California, United States, 96001
Actively Recruiting
11
DaVinci Research LLC.
Roseville, California, United States, 95661
Actively Recruiting
12
Allergy & Asthma Associates of Santa Clara Valley
San Jose, California, United States, 95117
Actively Recruiting
13
California Allergy & Asthma Medical Group Inc.
San Jose, California, United States, 95117
Actively Recruiting
14
Allergy, Asthma, and Immunology Medical Group
Ventura, California, United States, 93003
Actively Recruiting
15
Allergy and Asthma Clinical Research Inc
Walnut Creek, California, United States, 94598
Actively Recruiting
16
Lynn Institute of Denver
Aurora, Colorado, United States, 80012
Actively Recruiting
17
Innovative Research of West Florida, Inc.
Clearwater, Florida, United States, 33756
Actively Recruiting
18
Omega Research Debary, LLC
DeBary, Florida, United States, 32713
Actively Recruiting
19
Jacksonville Center for Clinical Research
Jacksonville, Florida, United States, 32216
Actively Recruiting
20
Clinical Site Partners, LLC Leesburg dba Flourish Research
Leesburg, Florida, United States, 34748
Actively Recruiting
21
Suncoast Research Group, LLC Miami - Little Havana dba Flourish Research
Miami, Florida, United States, 33135
Actively Recruiting
22
Well Pharma Medical Research Corporation
Miami, Florida, United States, 33173
Actively Recruiting
23
University of South Florida - PARENT
Tampa, Florida, United States, 33613
Actively Recruiting
24
Clinical Site Partners, LLC Orlando dba Flourish Research
Winter Park, Florida, United States, 32789
Actively Recruiting
25
Clinical Site Partners, LLC Orlando dba Flourish Research
Winter Park, Florida, United States, 32789
Actively Recruiting
26
Aeroallergy Research Laboratories of Savannah, Inc.
Savannah, Georgia, United States, 31406
Actively Recruiting
27
Duly Health and Care
Winfield, Illinois, United States, 60190
Actively Recruiting
28
Accellacare of McFarland Clinic
Ames, Iowa, United States, 50010
Actively Recruiting
29
The Iowa Clinic, PC
West Des Moines, Iowa, United States, 50266
Actively Recruiting
30
University of Kansas Medical Center
Kansas City, Kansas, United States, 66160
Actively Recruiting
31
Bluegrass Allergy Research
Lexington, Kentucky, United States, 40509
Actively Recruiting
32
Allergy & Asthma Specialists, PSC
Owensboro, Kentucky, United States, 42301
Actively Recruiting
33
Continental Clinical Solutions, LLC
Towson, Maryland, United States, 21204
Actively Recruiting
34
Infinity Medical Research Inc
Russells Mills, Massachusetts, United States, 02747
Actively Recruiting
35
Clinical Research Institute
Minneapolis, Minnesota, United States, 55402
Actively Recruiting
36
Mayo Clinic - Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
37
The Curators of the University of Missouri on behalf of University of Missouri Health Care
Columbia, Missouri, United States, 65212
Actively Recruiting
38
Midwest Chest Consultants
Saint Charles, Missouri, United States, 63301
Actively Recruiting
39
Sundance Clinical Research
St Louis, Missouri, United States, 63141
Terminated
40
The Clinical Research Center, LLC
St Louis, Missouri, United States, 63141
Actively Recruiting
41
Montana Medical Research, Inc.
Missoula, Montana, United States, 59808
Actively Recruiting
42
AMR Las Vegas
Las Vegas, Nevada, United States, 89119
Actively Recruiting
43
Hackensack University Medical Center
Hackensack, New Jersey, United States, 07601
Actively Recruiting
44
Allergy Partners of New Jersey P C
Ocean City, New Jersey, United States, 07712
Actively Recruiting
45
The Valley Hospital
Paramus, New Jersey, United States, 07652
Actively Recruiting
46
St Josephs Physicians Med PC Pulmonary Health
Liverpool, New York, United States, 13088
Actively Recruiting
47
Equity Medical LLC
New York, New York, United States, 10023
Actively Recruiting
48
Allergy Partners Clinical Research
Asheville, North Carolina, United States, 28803
Actively Recruiting
49
Clinical Research of Gastonia
Gastonia, North Carolina, United States, 28054
Actively Recruiting
50
M3 Wake Research, Inc.
Raleigh, North Carolina, United States, 27612
Actively Recruiting
51
Accellacare
Winston-Salem, North Carolina, United States, 27103
Actively Recruiting
52
Southeastern Research Center LLC
Winston-Salem, North Carolina, United States, 27103
Actively Recruiting
53
Remington-Davis, Inc.
Columbus, Ohio, United States, 43215
Terminated
54
Lynn Health Science Institute
Oklahoma City, Oklahoma, United States, 73112
Actively Recruiting
55
Vital Prospects Clinical Research Institute, P.C.
Tulsa, Oklahoma, United States, 74136
Actively Recruiting
56
Northwest Research Center
Portland, Oregon, United States, 97202
Actively Recruiting
57
Suburban Research Associates
West Chester, Pennsylvania, United States, 19380
Actively Recruiting
58
Care Access Research - Warwick 1
Warwick, Rhode Island, United States, 02886
Actively Recruiting
59
Lowcountry Lung and Critical Care, P.A.
Charleston, South Carolina, United States, 29406
Actively Recruiting
60
Accellacare
Mt. Pleasant, South Carolina, United States, 29464
Actively Recruiting
61
Clinical Research of Rock Hill
Rock Hill, South Carolina, United States, 29732
Actively Recruiting
62
Internal Medicine and Pediatric Associates of Bristol, PC
Bristol, Tennessee, United States, 37620
Actively Recruiting
63
Accellacare d/b/a Accellacare of Knoxville
Knoxville, Tennessee, United States, 37938
Actively Recruiting
64
Pharmaceutical Research & Consulting, Inc.
Dallas, Texas, United States, 75231
Actively Recruiting
65
Houston Methodist Hospital
Houston, Texas, United States, 77030
Actively Recruiting
66
South Texas Allergy & Asthma Medical Professionals
San Antonio, Texas, United States, 78229
Actively Recruiting
67
Alamo ENT Associates
San Antonio, Texas, United States, 78258
Actively Recruiting
68
TPMG Clinical Research Williamsburg
Williamsburg, Virginia, United States, 23188
Actively Recruiting
69
Allergy, Asthma & Sinus Center, SC
Greenfield, Wisconsin, United States, 53228
Actively Recruiting
70
UZ Leuven
Leuven, Belgium, 3000
Actively Recruiting
71
AZ Sint-Maarten
Mechelen, Belgium, 2800
Actively Recruiting
72
Pneumocare
Namur, Belgium, 5380
Actively Recruiting
73
AZ Delta
Roeselare, Belgium, 8800
Actively Recruiting
74
Dynamic Drug Advancement
Ajax, Ontario, Canada, L1S 2J5
Actively Recruiting
75
BLC Clinical Research
Burlington, Ontario, Canada, L7N 3V2
Actively Recruiting
76
McMaster University
Hamilton, Ontario, Canada, L8N 3Z5
Actively Recruiting
77
Inspiration Research Limited
Toronto, Ontario, Canada, M5T 3A9
Actively Recruiting
78
Recherche GCP Research
Montreal, Quebec, Canada, H1Y 3H5
Actively Recruiting
79
DIEX Recherche Quebec Inc.
Québec, Quebec, Canada, G1V 4T3
Actively Recruiting
80
Clinique Specialisee en Allergie de la Capitale
Québec, Quebec, Canada, G1V 4W2
Actively Recruiting
81
Clinique de pneumologie et du sommeil de Lanaudière
Saint-Charles-Borromée, Quebec, Canada, J6E 2B4
Terminated
82
DIEX Recherche Sherbrooke Inc.
Sherbrooke, Quebec, Canada, J1L 0H8
Actively Recruiting
83
DIEX Recherche Victoriaville Inc.
Victoriaville, Quebec, Canada, G6P 3Z8
Actively Recruiting
84
Pneumologisches Studienzentrum Muenchen West
Munich, Bavaria, Germany, 81241
Actively Recruiting
85
Lungenzentrum Darmstadt
Darmstadt, Hesse, Germany, 64283
Actively Recruiting
86
Medaimun GmbH
Frankfurt am Main, Hesse, Germany, 60596
Actively Recruiting
87
Zentrum fuer ambulante pneumologische Forschung Marburg GbR
Marburg, Hesse, Germany, 35037
Actively Recruiting
88
Pneumologicum Halle
Halle, Saxony-Anhalt, Germany, 06108
Actively Recruiting
89
Pneumologisches Forschungsinstitut Hohegeest GbR
Geesthacht, Schleswig-Holstein, Germany
Actively Recruiting
90
Velocity Research Germany GmbH
Lübeck, Schleswig-Holstein, Germany, 23552
Actively Recruiting
91
Pneumologisches Studienzentrum MVZ "Die Lungenärzte"
Berlin, State of Berlin, Germany, 10961
Actively Recruiting
92
Prywatny Gabinet Internistyczno-Alergologiczny
Bialystok, Poland, 15-010
Actively Recruiting
93
Prywatna Praktyka Lekarska Gabinet Pediatryczno-Alergologiczny
Bialystok, Poland, 15-430
Actively Recruiting
94
Centrum Medyczne Pratia Bydgoszcz
Bydgoszcz, Poland, 85-796
Actively Recruiting
95
Centrum Medyczne Pratia Czestochowa
Częstochowa, Poland, 42-217
Actively Recruiting
96
Ostrowieckie Centrum Medyczne spółka cywilna Anna Olech-Cudzik, Krzysztof Cudzik
Ostrowiec Świętokrzyski, Poland, 27-400
Actively Recruiting
97
Centrum Medyczne Lucyna Andrzej Dymek s.c.
Strzelce Opolskie, Poland, 47-100
Actively Recruiting
98
Gabinet Pulmonologii i Diagnostyki Chorób Alergicznych Dorota Maria Małosek
Szczecin, Poland, 70-1111
Actively Recruiting
99
Alergo-Med Specjalistyczna Przychodnia Lekarska Sp. Z .O.O.
Tarnów, Poland, 33-100
Actively Recruiting
100
Ormeau Clinical Trials Ltd
Belfast, Belfast, United Kingdom, BT2 8BG
Actively Recruiting
101
Belfast City Hospital
Belfast, Belfast, United Kingdom, BT9 7AB
Actively Recruiting
102
West Walk Surgery
Bristol, Bristol, United Kingdom, BS374AX
Actively Recruiting
103
Castle Hill Hospital
Cottingham, East Riding of Yorkshire, United Kingdom, HU16 5JQ
Actively Recruiting
104
King's College Hospital
London, Greater London, United Kingdom, SE5 9RS
Actively Recruiting
105
Wythenshawe Hospital
Wythenshawe, Greater Manchester, United Kingdom, M23 9LT
Actively Recruiting
106
Nottingham City Hospital
Nottingham, Nottinghamshire, United Kingdom, NG56EG
Actively Recruiting
107
North Tyneside General Hospital
North Shields, Tyne & Wear, United Kingdom, NE29 8NH
Actively Recruiting
Research Team
N
Nocion Clinical Trials
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
4
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