Actively Recruiting
A Study to Assess Growth in Children With Idiopathic Short Stature
Led by BioMarin Pharmaceutical · Updated on 2025-11-14
300
Participants Needed
40
Research Sites
855 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Study 111-903 will generate baseline growth data in children with ISS by collecting growth measurements and other variables of interest.
CONDITIONS
Official Title
A Study to Assess Growth in Children With Idiopathic Short Stature
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants must be older than 2 years and 14 years or younger for females, or 16 years or younger for males at consent signing
- Height Z-score must be -2.25 standard deviations or lower compared to peers of the same age and sex using CDC growth charts
- Participants may have never received human growth hormone (hGH) or may currently be receiving hGH treatment
- Historic growth hormone stimulation test showing serum or plasma GH level greater than 10 bcg/L
- Parent or guardian must be willing and able to provide signed informed consent
You will not qualify if you...
- Diagnosis of systemic diseases that may cause short stature, such as renal, neoplastic, pulmonary, cardiac, gastrointestinal, immunologic, or metabolic diseases, unless well controlled as approved by the Medical Monitor
- Known pituitary hormone deficiencies
- Bone age advanced more than 3 years beyond chronological age
- For hGH-nafve participants, historic stimulation test GH level over 10 bcg/L or serum IGF-1 in normal age range (-1.00 to +2.00 SDs)
- For participants on hGH treatment, historic pre-treatment stimulation test GH level over 10 bcg/L or serum IGF-1 between -1.00 and +2.00 SDs
- Received any investigational product or medical device within 6 months before screening visit
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 40 locations
1
Phoenix Children's Hospital - Thomas Campus (Main)
Phoenix, Arizona, United States, 85016
Actively Recruiting
2
Children's Hospital Los Angeles
Los Angeles, California, United States, 90027
Actively Recruiting
3
Harbor-UCLA Medical Center - The Lundquist Institute (Los Angeles Biomedical Research Institute (LA BioMed)
Los Angeles, California, United States, 90502
Actively Recruiting
4
Children's Hospital of Orange County Main Campus - Orange
Orange, California, United States, 92868
Actively Recruiting
5
Center Of Excellence in Diabetes and Endocrinology
Sacramento, California, United States, 95821
Actively Recruiting
6
Rady Children's Hospital - San Diego
San Diego, California, United States, 92123
Actively Recruiting
7
University of California San Francisco (UCSF)
San Francisco, California, United States, 94143
Actively Recruiting
8
Connecticut Children's Medical Center
Hartford, Connecticut, United States, 06106-3322
Actively Recruiting
9
Yale School of Medicine
New Haven, Connecticut, United States, 06511
Actively Recruiting
10
Children's National Health System
Washington D.C., District of Columbia, United States, 20010
Actively Recruiting
11
Nemours Children's Clinic
Jacksonville, Florida, United States, 32207
Actively Recruiting
12
Nicklaus Children's Hospital
Miami, Florida, United States, 33155
Actively Recruiting
13
Nemours Children's Health System - Corporate Headquarters
Pensacola, Florida, United States, 32514
Actively Recruiting
14
Centricity Research
Columbus, Georgia, United States, 31904
Actively Recruiting
15
St. Luke's Children's Endocrinology
Boise, Idaho, United States, 83712
Actively Recruiting
16
Rocky Mountain Diabetes Center - Idaho Falls
Idaho Falls, Idaho, United States, 83404-7596
Actively Recruiting
17
Rocky Mountain Clinical Research - Idaho Falls
Idaho Falls, Idaho, United States, 83404
Actively Recruiting
18
University of Louisville School Of Medicine - Norton Children's Hospital
Louisville, Kentucky, United States, 40202
Actively Recruiting
19
Ochsner Health Center for Children - New Orleans
New Orleans, Louisiana, United States, 70121
Actively Recruiting
20
University of Michigan
Ann Arbor, Michigan, United States, 48109-4000
Actively Recruiting
21
University of Minnesota Medical School - Masonic Children's Hospital - Pediatric Specialty Care Explorer Clinic
Minneapolis, Minnesota, United States, 55454
Actively Recruiting
22
Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, United States, 03756
Actively Recruiting
23
University of Iowa Stead Family Children's Hospital
Princeton, New Jersey, United States, 08540
Actively Recruiting
24
UBMD Pediatrics
Buffalo, New York, United States, 14203
Actively Recruiting
25
ACGC Research, NYU Ambulatory Care Garden City
Garden City, New York, United States, 11530
Actively Recruiting
26
New York University Grossman School of Medicine
New York, New York, United States, 10016
Actively Recruiting
27
Icahn School of Medicine at Mount Sinai (ISMMS) - The Mount Sinai Hospital (MSH) - Pediatric Associates
New York, New York, United States, 10029
Actively Recruiting
28
Montefiore Medical Center (MMC) - The Children's Hospital at Montefiore (CHAM)
The Bronx, New York, United States, 10467
Actively Recruiting
29
WakeMed Children's - Pediatric Endocrinology - North Raleigh
Raleigh, North Carolina, United States, 27615
Actively Recruiting
30
Cincinnati Children's Hospital Medical Center Burnet Campus
Cincinnati, Ohio, United States, 45229
Actively Recruiting
31
Nationwide Children's Hospital
Columbus, Ohio, United States, 43205
Actively Recruiting
32
Prisma Health Children's Hospital - Midlands
Columbia, South Carolina, United States, 29203
Actively Recruiting
33
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232-2578
Actively Recruiting
34
University of Texas Southwestern Medical Center
Dallas, Texas, United States, 75390
Actively Recruiting
35
Cook Children's Endocrinology
Fort Worth, Texas, United States, 76104
Actively Recruiting
36
Baylor College of Medicine
Houston, Texas, United States, 77030
Actively Recruiting
37
Seattle Children's Hospital
Seattle, Washington, United States, 98105
Actively Recruiting
38
Charleston Area Medical Center (CAMC) Health System
Charleston, West Virginia, United States, 25304
Actively Recruiting
39
Charleston Area Medical Center (CAMC) Health System
Charleston, West Virginia, United States, 25304
Actively Recruiting
40
Medical College of Wisconsin, Children's Hospital
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
Research Team
T
Trial Specialist
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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