Actively Recruiting
A Study to Assess the Real-World Effectiveness of Mavacamten in Adult Patients With Obstructive Hypertrophic Cardiomyopathy in China
Led by Bristol-Myers Squibb · Updated on 2026-05-11
500
Participants Needed
15
Research Sites
136 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to assess the effectiveness of mavacamten treatment in Chinese adults with symptomatic obstructive hypertrophic cardiomyopathy (HCM) in real-world clinical practice
CONDITIONS
Official Title
A Study to Assess the Real-World Effectiveness of Mavacamten in Adult Patients With Obstructive Hypertrophic Cardiomyopathy in China
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants aged 18 years or older at the time of initial mavacamten prescription
- Participants who have started or are scheduled to start mavacamten based on clinical need
- Diagnosed with obstructive hypertrophic cardiomyopathy according to current American and European guidelines
- Documented left ventricular outflow tract gradient of 30 mmHg or higher at rest or with provocation within 3 months prior to enrollment
- Left ventricular ejection fraction of 55% or higher measured by resting transthoracic echocardiography within 3 months prior to enrollment
- New York Heart Association (NYHA) class II or III symptoms documented within 3 months prior to enrollment
- For retrospective participants, essential baseline information and critical data must be available, with at least one key follow-up time point recorded
- Provided voluntary informed consent
You will not qualify if you...
- Known hypertrophic cardiomyopathy phenocopy diseases such as Fabry disease or amyloidosis
- Expected to undergo major cardiac surgery during the study
- Received invasive septal reduction treatment within 6 months prior to enrollment, including surgical myectomy or alcohol septal ablation
- Currently treated with disopyramide or ranolazine within 14 days prior to enrollment or expected to take these or certain other medications during the study
- Presence of other diseases that may prevent completion of 96 weeks follow-up
- Using or expected to use moderate to strong CYP2C19 or CYP3A4 inhibitors or inducers during the study
- Participating in other interventional clinical studies
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 15 locations
1
Local Institution - 0008
Beijing, Beijing Municipality, China, 100029
Not Yet Recruiting
2
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China, 100032
Actively Recruiting
3
Peking University First Affiliated Hospital
Beijing, Beijing Municipality, China, 100034
Actively Recruiting
4
Local Institution - 0009
Guangzhou, Guangdong, China, 510080
Not Yet Recruiting
5
The Second Afilliated Hospital of Hebei Medical University
Jiazhuang, Hebei, China, 050000
Actively Recruiting
6
Local Institution - 0003
Harbin, Heilongjiang, China, 150086
Not Yet Recruiting
7
Local Institution - 0007
Zhengzhou, Henan, China, 450052
Not Yet Recruiting
8
Suzhou Municipal Hospital
Suzhou, Jiangsu, China, 215002
Actively Recruiting
9
The Second Hospital of Jilin University
Changchun, Jilin, China, 130041
Actively Recruiting
10
Local Institution - 0005
Dalian, Liaoning, China, 116011
Not Yet Recruiting
11
Local Institution - 0013
Xi'an, Shan3xi, China, 710061
Not Yet Recruiting
12
West China Hospital of Sichuan University
Chengdu, Sichuan, China, 610041
Actively Recruiting
13
The Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, Zhejiang, China, 310009
Actively Recruiting
14
Local Institution - 0010
Jinan, China, 250012
Not Yet Recruiting
15
Zhongshan Hospital Fudan University
Shanghai, China, 200032
Actively Recruiting
Research Team
B
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
CONTACT
F
First line of the email MUST contain NCT # and Site #.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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