Actively Recruiting
A Study to Assess Real-world Patient Characteristics and Clinical Course for Symptomatic Patients With PKP2-ACM
Led by Lexeo Therapeutics · Updated on 2025-05-16
40
Participants Needed
6
Research Sites
188 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
An observational study to assess real-world patient characteristics and clinical course of disease in participants with PKP2-ACM.
CONDITIONS
Official Title
A Study to Assess Real-world Patient Characteristics and Clinical Course for Symptomatic Patients With PKP2-ACM
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults with a clinical diagnosis of ACM as defined by the 2010 revised Task Force Criteria (TFC)
- Documentation of a pathogenic or likely pathogenic truncating variant in PKP2
- Frequent premature ventricular contractions (PVCs)
- Patients must have an ICD placed prior to enrollment
- Left ventricular ejection fraction (LVEF) 60 50% for Part A participants
- Left ventricular ejection fraction (LVEF) 50% for Part B participants
You will not qualify if you...
- Evidence of variant(s) in addition to PKP2 that meet standard criteria to be considered pathogenic or likely pathogenic for an arrhythmogenic cardiomyopathy
- A history of other cardiac abnormalities as specified in the protocol
- New York Heart Association symptoms of heart failure of Class IV at the time of consent
- A history of prior gene transfer therapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 6 locations
1
Leland Stanford Junior University
Redwood City, California, United States, 94063-3126
Actively Recruiting
2
Johns Hopkins University
Baltimore, Maryland, United States, 21287
Actively Recruiting
3
Northshore University Healthsystem Research Institute
Columbia, Maryland, United States, 21044
Actively Recruiting
4
University of Michigan
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
5
Henry Ford Hospital
Detroit, Michigan, United States, 48202
Actively Recruiting
6
University of Rochester
Rochester, New York, United States, 14642
Actively Recruiting
Research Team
P
Person*: Lexeo Clinical Trials
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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