Actively Recruiting
Study to Assess the Safety and Effectiveness of NMRA-335140-501
Led by Neumora Therapeutics, Inc. · Updated on 2026-05-12
1000
Participants Needed
178
Research Sites
185 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a 52-week open-label extension (OLE) study that will evaluate the safety, tolerability, and effectiveness of NMRA-335140 in participants with major depressive disorder (MDD). Participants who completed a parent study investigating the efficacy and safety of NMRA-335140 as a treatment for MDD (ie, NMRA-335140-301, NMRA-335140-302, or NMRA-335140-303), and complete the 6 weeks double-blind treatment, provide informed consent, and meet eligibility criteria, may enter this extension study.
CONDITIONS
Official Title
Study to Assess the Safety and Effectiveness of NMRA-335140-501
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Completed a previous NMRA-335140 Phase 3 major depressive disorder study
- Signed an informed consent form for this study
- Willing to follow contraception requirements from the parent study
- Willing to comply with medication and therapy restrictions from the parent study
You will not qualify if you...
- Diagnosed with another major mental disorder such as bipolar 1 or 2, schizophrenia, or severe substance or alcohol use disorder (excluding nicotine)
- Considered at significant suicide risk or actively suicidal
- Non-adherent with medication or procedures in the parent study
- Experienced significant treatment emergent adverse events related to study medication in the parent study
- Have ocular abnormalities that prevent continued participation
- Use disallowed medications or therapies from the parent study
- Deemed inappropriate for participation by the investigator for other reasons
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 178 locations
1
Neumora Investigator site
Huntsville, Alabama, United States, 35801
Actively Recruiting
2
Neumora Investigator Site
Phoenix, Arizona, United States, 85012
Active, Not Recruiting
3
Neumora Investigator Site
Bentonville, Arkansas, United States, 72712
Active, Not Recruiting
4
Neumora Investigator Site #1
Little Rock, Arkansas, United States, 72211
Completed
5
Neumora Investigator site
Little Rock, Arkansas, United States, 72211
Active, Not Recruiting
6
Neumora Investigator Site
Rogers, Arkansas, United States, 72758
Completed
7
Neumora Investigator site
Bellflower, California, United States, 90706
Active, Not Recruiting
8
Neumora Investigator Site
Cerritos, California, United States, 90703
Active, Not Recruiting
9
Neumora Investigator Site
Encino, California, United States, 91316
Active, Not Recruiting
10
Neumora Investigator Site
Garden Grove, California, United States, 92845
Active, Not Recruiting
11
Neumora Investigator Site
Glendale, California, United States, 91206
Active, Not Recruiting
12
Neumora Investigator Site
Imperial, California, United States, 92251
Active, Not Recruiting
13
Neumora Investigator Site
Irvine, California, United States, 92614
Actively Recruiting
14
Neumora Investigator Site
Lafayette, California, United States, 94549
Active, Not Recruiting
15
Neumora Investigator Site #1
Long Beach, California, United States, 90807
Actively Recruiting
16
Neumora Investigator site
Long Beach, California, United States, 90807
Active, Not Recruiting
17
Neumora Investigator Site
Los Angeles, California, United States, 90015
Actively Recruiting
18
Neumora Investigator Site
Newport Beach, California, United States, 92660
Actively Recruiting
19
Neumora Investigator Site
Oceanside, California, United States, 92056
Active, Not Recruiting
20
Neumora Investigator Site #1
Orange, California, United States, 92868
Active, Not Recruiting
21
Neumora Investigator Site
Orange, California, United States, 92868
Completed
22
Neumora Investigator Site
Riverside, California, United States, 92506
Completed
23
Neumora Investigator Site
San Diego, California, United States, 92103
Active, Not Recruiting
24
Neumora Investigator Site
San Francisco, California, United States, 94107
Active, Not Recruiting
25
Neumora Investigator Site
San Jose, California, United States, 95124
Active, Not Recruiting
26
Neumora Investigator Site
Santa Ana, California, United States, 92704
Completed
27
Neumora Investigator Site
Sherman Oaks, California, United States, 91403
Active, Not Recruiting
28
Neumora Investigator Site
Temecula, California, United States, 92591
Active, Not Recruiting
29
Neumora Investigator Site
Torrance, California, United States, 90504
Active, Not Recruiting
30
Neumora Investigator Site
Colorado Springs, Colorado, United States, 80910
Completed
31
Neumora Investigator Site
New Haven, Connecticut, United States, 06520
Actively Recruiting
32
Neumora Investigator Site
Norwalk, Connecticut, United States, 06851
Completed
33
Neumora Investigator Site
Bradenton, Florida, United States, 34205
Actively Recruiting
34
Neumora Investigator Site
Brandon, Florida, United States, 33511
Actively Recruiting
35
Neumora Investigator Site
Gainesville, Florida, United States, 32607
Active, Not Recruiting
36
Neumora Investigator Site
Hallandale, Florida, United States, 33009
Active, Not Recruiting
37
Neumora Investigator Site
Hialeah, Florida, United States, 33012
Actively Recruiting
38
Neumora Investigator Site
Hialeah, Florida, United States, 33016
Active, Not Recruiting
39
Neumora Investigator Site
Hollywood, Florida, United States, 33024
Actively Recruiting
40
Neumora Investigator Site
Jacksonville, Florida, United States, 32256
Active, Not Recruiting
41
Neumora Investigator Site
Lauderhill, Florida, United States, 33319
Active, Not Recruiting
42
Neumora Investigator Site
Maitland, Florida, United States, 32751
Active, Not Recruiting
43
Neumora Investigator Site
Miami, Florida, United States, 33122
Active, Not Recruiting
44
Neumora Investigator Site
Miami, Florida, United States, 33126
Active, Not Recruiting
45
Neumora Investigator Site
Miami, Florida, United States, 33133
Active, Not Recruiting
46
Neumora Investigator Site
Miami, Florida, United States, 33137
Active, Not Recruiting
47
Neumora Investigator Site
Miami, Florida, United States, 33143
Actively Recruiting
48
Neumora Investigator Site
Miami, Florida, United States, 33165
Actively Recruiting
49
Neumora Investigator Site
Miami, Florida, United States, 33174
Actively Recruiting
50
Neumora Investigator site
Miami, Florida, United States, 33183
Active, Not Recruiting
51
Neumora Investigator Site
Miami Beach, Florida, United States, 33140
Actively Recruiting
52
Neumora Investigator site
Miami Lakes, Florida, United States, 33014
Active, Not Recruiting
53
Neumora Investigator Site #1
Miami Lakes, Florida, United States, 33016
Completed
54
Neumora Investigator Site #2
Miami Lakes, Florida, United States, 33016
Actively Recruiting
55
Neumora Investigator Site
Miami Springs, Florida, United States, 33166
Active, Not Recruiting
56
Neumora Investigator Site #1
Orlando, Florida, United States, 32801
Actively Recruiting
57
Neumora Investigator site
Orlando, Florida, United States, 32801
Active, Not Recruiting
58
Neumora Investigator Site
Orlando, Florida, United States, 32803
Actively Recruiting
59
Neumora Investigator Site
Orlando, Florida, United States, 32807
Actively Recruiting
60
Neumora Investigator Site
Pembroke Pines, Florida, United States, 33024
Actively Recruiting
61
Neumora Investigator Site #1
Pompano Beach, Florida, United States, 33060
Actively Recruiting
62
Neumora Investigator Site
Pompano Beach, Florida, United States, 33060
Active, Not Recruiting
63
Neumora Investigator Site
Saint Augustine, Florida, United States, 32086
Completed
64
Neumora Investigator Site
Tampa, Florida, United States, 33607
Active, Not Recruiting
65
Neumora Investigator Site #1
Tampa, Florida, United States, 33613
Active, Not Recruiting
66
Neumora Investigator Site
Tampa, Florida, United States, 33613
Active, Not Recruiting
67
Neumora Investigator Site
Atlanta, Georgia, United States, 30318
Actively Recruiting
68
Neumora Investigator Site #1
Atlanta, Georgia, United States, 30328
Active, Not Recruiting
69
Neumora Investigator Site
Atlanta, Georgia, United States, 30328
Actively Recruiting
70
Neumora Investigator Site
Atlanta, Georgia, United States, 30338
Completed
71
Neumora Investigator Site
Decatur, Georgia, United States, 30030
Active, Not Recruiting
72
Neumora Investigator Site
Marietta, Georgia, United States, 30060
Active, Not Recruiting
73
Neumora Investigator Site
Savannah, Georgia, United States, 31405
Active, Not Recruiting
74
Neumora Investigator Site
Chicago, Illinois, United States, 60634
Active, Not Recruiting
75
Neumora Investigator Site
Warrenville, Illinois, United States, 60555
Active, Not Recruiting
76
Neumora Investigator Site
Marrero, Louisiana, United States, 70072
Completed
77
Neumora Investigator Site
New Orleans, Louisiana, United States, 70115
Actively Recruiting
78
Neumora Investigator Site
Baltimore, Maryland, United States, 21208
Actively Recruiting
79
Neumora Investigator site
Towson, Maryland, United States, 21204
Actively Recruiting
80
Neumora Investigator Site
Boston, Massachusetts, United States, 02116
Active, Not Recruiting
81
Neumora Investigator Site
Boston, Massachusetts, United States, 02131
Actively Recruiting
82
Neumora Investigator site
Methuen, Massachusetts, United States, 01844
Completed
83
Neumora Investigator site
Springfield, Massachusetts, United States, 01103
Actively Recruiting
84
Neumora Investigator Site
Watertown, Massachusetts, United States, 02472
Active, Not Recruiting
85
Neumora Investigator site
Bloomfield Township, Michigan, United States, 48302
Completed
86
Neumora Investigator Site
Mankato, Minnesota, United States, 56001
Active, Not Recruiting
87
Neumora Investigator Site
Flowood, Mississippi, United States, 39232
Active, Not Recruiting
88
Neumora Investigator Site
Saint Charles, Missouri, United States, 63304
Completed
89
Neumora Investigator Site
St Louis, Missouri, United States, 63141
Actively Recruiting
90
Neumora Investigator Site
Las Vegas, Nevada, United States, 89102
Completed
91
Neumora Investigator Site
Berlin, New Jersey, United States, 08009
Actively Recruiting
92
Neumora Investigator site
Princeton, New Jersey, United States, 08540
Actively Recruiting
93
Neumora Investigator Site
Toms River, New Jersey, United States, 08755
Actively Recruiting
94
Neumora Investigator Site
Albuquerque, New Mexico, United States, 87109
Active, Not Recruiting
95
Neumora Investigator Site
Brooklyn, New York, United States, 11224
Active, Not Recruiting
96
Neumora Investigator Site
Buffalo, New York, United States, 14215
Active, Not Recruiting
97
Neumora Investigator Site
Cedarhurst, New York, United States, 11516
Active, Not Recruiting
98
Neumora Investigator Site
Inwood, New York, United States, 11096
Actively Recruiting
99
Neumora Investigator Site
New York, New York, United States, 10017
Active, Not Recruiting
100
Neumora Investigator Site
New York, New York, United States, 10029
Active, Not Recruiting
101
Neumora Investigator Site
New York, New York, United States, 10036
Active, Not Recruiting
102
Neumora Investigator Site
Staten Island, New York, United States, 10310
Active, Not Recruiting
103
Neumora Investigator Site
Staten Island, New York, United States, 10314
Completed
104
Neumora Investigator Site
The Bronx, New York, United States, 10461
Actively Recruiting
105
Neumora Investigator Site
Charlotte, North Carolina, United States, 28211
Actively Recruiting
106
Neumora Investigator Site
Monroe, North Carolina, United States, 28112
Active, Not Recruiting
107
Neumora Investigator Site
Columbus, Ohio, United States, 43210
Active, Not Recruiting
108
Neumora Investigator Site
Dayton, Ohio, United States, 45417
Active, Not Recruiting
109
Neumora Investigator Site
North Canton, Ohio, United States, 44720
Active, Not Recruiting
110
Neumora Investigator Site
Edmond, Oklahoma, United States, 73013
Actively Recruiting
111
Neumora Investigator Site
Oklahoma City, Oklahoma, United States, 73118
Actively Recruiting
112
Neumora Investigator Site
Allentown, Pennsylvania, United States, 18104
Actively Recruiting
113
Neumora Investigator Site
Media, Pennsylvania, United States, 19063
Completed
114
Neumora Investigator Site
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
115
Neumora Investigator Site
Memphis, Tennessee, United States, 38119
Active, Not Recruiting
116
Neumora Investigator Site
Austin, Texas, United States, 78737
Active, Not Recruiting
117
Neumora Investigator site
Austin, Texas, United States, 78759
Actively Recruiting
118
Neumora Investigator Site
Dallas, Texas, United States, 75243
Actively Recruiting
119
Neumora Investigator Site
DeSoto, Texas, United States, 75115
Actively Recruiting
120
Neumora Investigator Site
Fort Worth, Texas, United States, 76104
Actively Recruiting
121
Neumora Investigator Site #1
Houston, Texas, United States, 77030
Actively Recruiting
122
Neumora Investigator Site
Houston, Texas, United States, 77030
Completed
123
Neumora Investigator Site
Houston, Texas, United States, 77090
Active, Not Recruiting
124
Neumora Investigator Site
Wichita Falls, Texas, United States, 76309
Completed
125
Neumora Investigator Site
Bellevue, Washington, United States, 98007
Active, Not Recruiting
126
Neumora Investigator Site #1
Everett, Washington, United States, 98201
Active, Not Recruiting
127
Neumora Investigator Site
Curitiba, Paraná, Brazil, 80240280
Actively Recruiting
128
Neumora Investigator Site
Botafogo - Rio de Janeiro, Rio de Janeiro, Brazil, 22270-060
Actively Recruiting
129
Neumora Investigator Site
Porto Alegre, Rio Grande do Sul, Brazil, 90610-001
Active, Not Recruiting
130
Neumora Investigator Site
Santa Cecília, São Paulo, Brazil, 01228-000
Actively Recruiting
131
Neumora Investigator Site
São Bernardo do Campo, São Paulo, Brazil, 09726150
Actively Recruiting
132
Neumora Investigator Site
São José do Rio Preto, São Paulo, Brazil, 15090-000
Active, Not Recruiting
133
Neumora Investigator Site
São Paulo, Brazil, 01236030
Actively Recruiting
134
Neumora Investigator Site
Cherven Bryag, Pleven, Bulgaria, 5980
Completed
135
Neumora Investigator Site
Sofia, Sofia-Grad, Bulgaria, 1408
Actively Recruiting
136
Neumora Investigator Site
Sofia, Sofia-Grad, Bulgaria, 1463
Active, Not Recruiting
137
Neumora Investigator Site
Sofia, Sofia-Grad, Bulgaria, 1680
Active, Not Recruiting
138
Neumora Investigator Site
Varosha, Targovishte, Bulgaria, 7700
Active, Not Recruiting
139
Neumora Investigator Site
Kardzhali, Bulgaria, 6600
Active, Not Recruiting
140
Neumora Investigator Site
Pleven, Bulgaria, 5800
Completed
141
Neumora Investigator Site
Varna, Bulgaria, 9020
Active, Not Recruiting
142
Neumora Investigator Site
Kelowna, British Columbia, Canada, V1Y 1Z9
Active, Not Recruiting
143
Neumora Investigator Site
Hamilton, Ontario, Canada, L8S 1B7
Active, Not Recruiting
144
Neumora Investigator Site
Markham, Ontario, Canada, L3R 1A3
Completed
145
Neumora Investigator Site
Mississauga, Ontario, Canada, L5L 1W8
Active, Not Recruiting
146
Neumora Investigator Site
Toronto, Ontario, Canada, M5S 1M2
Active, Not Recruiting
147
Neumora Investigator Site
Santiago, Santiago Metropolitan, Chile, 7500710
Actively Recruiting
148
Neumora Investigator Site
Santiago, Santiago Metropolitan, Chile, 7560356
Actively Recruiting
149
Neumora Investigator Site
Santiago, Santiago Metropolitan, Chile, 7561282
Active, Not Recruiting
150
Neumora Investigator Site
Santiago, Santiago Metropolitan, Chile, 8330034
Active, Not Recruiting
151
Neumora Investigator Site
Antofagasta, Chile, 1270244
Actively Recruiting
152
Neumora Investigator Site
Pilsen, Plzeň, Czechia, 301 00
Actively Recruiting
153
Neumora Investigator Site
Prague, Prague, Czechia, 186 00
Active, Not Recruiting
154
Neumora Investigator Site
Kladno, South Bohemian, Czechia, 272 01
Completed
155
Neumora Investigator Site
Kladno, Czechia, 272 01
Actively Recruiting
156
Neumora Investigator Site
Prague, Czechia, 109 00
Completed
157
Neumora Investigator Site
Helsinki, Etelä-Suomen Lääni, Finland, 00100
Actively Recruiting
158
Neumora Investigator Site
Turku, Etelä-Suomen Lääni, Finland, 20520
Completed
159
Neumora Investigator Site
Oulu, Oulun Lääni, Finland, 90100
Active, Not Recruiting
160
Neumora Investigator Site
Clermont-Ferrand, Auvergne-Rhône-Alpes, France, 63000
Active, Not Recruiting
161
Neumora Investigator Site
Douai, Hauts-de-France, France, 59500
Actively Recruiting
162
Neumora Investigator Site
Montpellier, Hérault, France, 34295
Active, Not Recruiting
163
Neumora Investigator Site
La Roche-sur-Yon, Vendée, France, 85000
Actively Recruiting
164
Neumora Investigator Site
Poitiers, Vienne, France, 86000
Completed
165
Neumora Investigator Site #1
Berlin, Germany, 10117
Completed
166
Neumora Investigator Site
Berlin, Germany, 10117
Active, Not Recruiting
167
Neumora Investigator Site
Berlin, Germany, 10629
Actively Recruiting
168
Neumora Investigator Site
Berlin, Germany, 13187
Actively Recruiting
169
Neumora Investigator Site
Hamburg, Germany, 20253
Completed
170
Neumora Investigator Site
Suchy Las, Greater Poland Voivodeship, Poland, 62-002
Active, Not Recruiting
171
Neumora Investigator Site
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland, 85-133
Active, Not Recruiting
172
Neumora Investigator Site
Wroclaw, Lower Silesian Voivodeship, Poland, 50-414
Actively Recruiting
173
Neumora Investigator Site
Lublin, Lublin Voivodeship, Poland, 20-109
Completed
174
Neumora Investigator Site
Lublin, Lublin Voivodeship, Poland, 20-582
Completed
175
Neumora Investigator Site
Białystok, Podkarpackie Voivodeship, Poland, 15-879
Actively Recruiting
176
Neumora Investigator Site
Gdansk, Pomeranian Voivodeship, Poland, 80-438
Completed
177
Neumora Investigator Site
Lund, Skåne County, Sweden, 222 22
Actively Recruiting
178
Neumora Investigator Site
Stockholm, Stolkholm Ian, Sweden, 113 29
Active, Not Recruiting
Research Team
S
Study Contact
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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