Actively Recruiting
A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants
Led by AbbVie · Updated on 2026-01-05
2800
Participants Needed
139
Research Sites
213 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will evaluate the efficacy and safety of Armour Thyroid treatment compared with synthetic T4 in subjects who have primary hypothyroidism and are currently stabilized (i.e., in-range thyroid-stimulating hormone \[TSH\]) on synthetic T4 treatment. This study will also therefore evaluate the efficacy and safety of dose conversion from synthetic T4 therapy to Armour Thyroid therapy.
CONDITIONS
Official Title
A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of primary hypothyroidism made at least 12 months before screening
- Continuous thyroid replacement therapy with synthetic T4 for at least 12 months before screening
- Stable daily dose of synthetic T4 of at least 25 mcg at screening
- Documentation of at least one in-range TSH (0.45 - 4.12 mIU/L) at screening and one additional in-range TSH 6 weeks to 12 months prior to screening
You will not qualify if you...
- Any condition or surgery affecting absorption, distribution, metabolism, or excretion of Armour Thyroid or synthetic T4
- History of alcohol or substance abuse within 6 months before screening
- Known or suspected allergy or intolerance to Armour Thyroid, synthetic T4, other thyroid medications, or pork products
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 139 locations
1
Central Research Associates /ID# 255719
Birmingham, Alabama, United States, 35205
Actively Recruiting
2
UAB Hospital /ID# 262565
Birmingham, Alabama, United States, 35233-1932
Actively Recruiting
3
Kaiser San Diego Dept Endocrinology, SCPMG /ID# 262552
Bonita, California, United States, 91902-1230
Actively Recruiting
4
Facey Medical Foundation - Burbank /ID# 262104
Burbank, California, United States, 91505-4554
Actively Recruiting
5
John Muir Medical Center /ID# 257103
Concord, California, United States, 94520
Actively Recruiting
6
Diagnamics Inc. /ID# 262680
Encinitas, California, United States, 92024
Actively Recruiting
7
Providence - St. Jude Medical Center /ID# 256520
Fullerton, California, United States, 92835
Actively Recruiting
8
NorCal Medical Research /ID# 256512
Greenbrae, California, United States, 94904
Actively Recruiting
9
Velocity Clinical Research - Huntington Park /ID# 259044
Huntington Park, California, United States, 90255-2951
Actively Recruiting
10
Scripps Whittier Diabetes Institute /ID# 259215
La Jolla, California, United States, 92037
Actively Recruiting
11
Facey Medical Foundation /ID# 260863
Mission Hills, California, United States, 91345
Actively Recruiting
12
Hoag Memorial Hospital Presbyterian /ID# 260990
Newport Beach, California, United States, 92663
Actively Recruiting
13
Diabetes Associates Medical Group /ID# 256949
Orange, California, United States, 92866-2862
Actively Recruiting
14
Western University of Health Sciences /ID# 262183
Pomona, California, United States, 91766
Actively Recruiting
15
Research at Mills-Peninsula Medical Center - Sutter Health /ID# 258825
San Mateo, California, United States, 94404
Actively Recruiting
16
Care Access - Santa Clarita /ID# 262573
Santa Clarita, California, United States, 91321
Actively Recruiting
17
Facey Medical Foundation - Valencia /ID# 262102
Santa Clarita, California, United States, 91355-4462
Actively Recruiting
18
Olive View UCLA Medical Center /ID# 259092
Sylmar, California, United States, 91342-1437
Actively Recruiting
19
The Lundquist Institute at Harbor-UCLA Medical Center /ID# 262572
Torrance, California, United States, 90502
Completed
20
Diablo Clinical Research /ID# 261329
Walnut Creek, California, United States, 94598
Actively Recruiting
21
San Fernando Valley Health Institute /ID# 257363
West Hills, California, United States, 91304-3837
Actively Recruiting
22
New England Research Associates - Bridgeport /ID# 262184
Bridgeport, Connecticut, United States, 06606
Actively Recruiting
23
Innovative Research of West Florida /ID# 257356
Clearwater, Florida, United States, 33756-2004
Actively Recruiting
24
ALL Medical Research /ID# 256748
Cooper City, Florida, United States, 33024
Actively Recruiting
25
Northeast Research Institute (NERI) /ID# 261841
Fleming Island, Florida, United States, 32003
Actively Recruiting
26
Northeast Research Institute (NERI) /ID# 261846
Fleming Island, Florida, United States, 32003
Actively Recruiting
27
The Center for Diabetes and Endocrine Care /ID# 255721
Fort Lauderdale, Florida, United States, 33312
Actively Recruiting
28
Encore Medical Research LLC /ID# 256758
Hollywood, Florida, United States, 33021
Actively Recruiting
29
East Coast Institute For Research - LaVilla - West Monroe Street /ID# 256972
Jacksonville, Florida, United States, 32204
Actively Recruiting
30
The University of Florida Heal /ID# 257361
Jacksonville, Florida, United States, 32207-4966
Actively Recruiting
31
East Coast Research - Jacksonville /ID# 256971
Jacksonville, Florida, United States, 32216
Actively Recruiting
32
Encore Research Group-Jacksonville Center for Clinical Research /ID# 256147
Jacksonville, Florida, United States, 32216
Actively Recruiting
33
Baptist Health Research Institute /ID# 260989
Jacksonville, Florida, United States, 32258
Actively Recruiting
34
South Florida Wellness & Clinic /ID# 256513
Margate, Florida, United States, 33063
Actively Recruiting
35
Med Research of Florida /ID# 257837
Miami, Florida, United States, 33186
Actively Recruiting
36
Ocean Blue Medical Research Center, Inc /ID# 260438
Miami Springs, Florida, United States, 33166
Actively Recruiting
37
Adult Medicine of Lake County - Mount Dora /ID# 257371
Mt. Dora, Florida, United States, 32757
Actively Recruiting
38
Suncoast Clinical Research Pasco County /ID# 257018
New Port Richey, Florida, United States, 34652
Actively Recruiting
39
West Orange Endocrinology /ID# 256139
Ocoee, Florida, United States, 34761-4547
Actively Recruiting
40
Suncoast Clinical Research - Palm Harbor /ID# 256741
Palm Harbor, Florida, United States, 34684
Actively Recruiting
41
Comprehensive Medical & Research Center /ID# 261678
Plantation, Florida, United States, 33317-2911
Actively Recruiting
42
Northeast Research Institute - St. Augustine /ID# 261857
Saint Augustine, Florida, United States, 32080
Actively Recruiting
43
Metabolic Research Inst /ID# 255729
West Palm Beach, Florida, United States, 33401
Actively Recruiting
44
Grady Clinical Research Center Grady Memorial Hospital /ID# 258419
Atlanta, Georgia, United States, 30303
Actively Recruiting
45
Atlanta Diabetes Associates /ID# 255736
Atlanta, Georgia, United States, 30318
Actively Recruiting
46
East Coast Institute for Research - Canton /ID# 256974
Canton, Georgia, United States, 30114
Actively Recruiting
47
Centricity Research - Endocrine Consultants Research /ID# 255738
Columbus, Georgia, United States, 31904
Actively Recruiting
48
Physicians Research Associates, LLC /ID# 255675
Lawrenceville, Georgia, United States, 30046
Actively Recruiting
49
The Jones Center Clinical Research /ID# 256529
Macon, Georgia, United States, 31210
Actively Recruiting
50
Endocrine Research Solutions /ID# 256784
Roswell, Georgia, United States, 30076
Actively Recruiting
51
Pacific Diabetes & Endocrine Center /ID# 259030
Honolulu, Hawaii, United States, 96813
Actively Recruiting
52
Rocky Mountain Clinical Research, LLC /ID# 256753
Idaho Falls, Idaho, United States, 83404-7596
Actively Recruiting
53
Northwestern University Feinberg School of Medicine /ID# 260677
Chicago, Illinois, United States, 60611-2927
Actively Recruiting
54
West Broadway Clinic /ID# 256756
Council Bluffs, Iowa, United States, 51501-3822
Actively Recruiting
55
Iowa Diabetes and Endocrinology Research Center /ID# 256750
West Des Moines, Iowa, United States, 50266
Actively Recruiting
56
Cotton O'Neil Diabetes & Endocrinology /ID# 256749
Topeka, Kansas, United States, 66606
Actively Recruiting
57
University of Louisville Hospital /ID# 262568
Louisville, Kentucky, United States, 40202
Actively Recruiting
58
Robley Rex VA Medical Center /ID# 262569
Louisville, Kentucky, United States, 40206
Actively Recruiting
59
L-MARC Research Center /ID# 255733
Louisville, Kentucky, United States, 40213-1014
Actively Recruiting
60
Pennington Biomedical Research Center /ID# 262390
Baton Rouge, Louisiana, United States, 70808
Actively Recruiting
61
Nola Care Clinical Research /ID# 260145
Metairie, Louisiana, United States, 70006-2930
Actively Recruiting
62
Omega Clinical Research /ID# 260162
Metairie, Louisiana, United States, 70006-2930
Actively Recruiting
63
Tufts Medical Center /ID# 262974
Boston, Massachusetts, United States, 02111-1552
Actively Recruiting
64
Circle Health Diabetes and Endocrine Center /ID# 270461
Dracut, Massachusetts, United States, 01826
Actively Recruiting
65
NECCR PrimaCare Research, LLC /ID# 256531
Fall River, Massachusetts, United States, 02721
Completed
66
Metro Detroit Endocrinology Center /ID# 260862
Dearborn, Michigan, United States, 48126
Actively Recruiting
67
Michigan Healthcare Professionals /ID# 260859
Farmington Hills, Michigan, United States, 48334
Actively Recruiting
68
Elite Clinical Research Center /ID# 256782
Flint, Michigan, United States, 48532
Actively Recruiting
69
Diabetes and Endocrinology Specialists /ID# 259068
Chesterfield, Missouri, United States, 63017
Actively Recruiting
70
University of Missouri Hospital /ID# 262562
Columbia, Missouri, United States, 65212
Actively Recruiting
71
Jefferson City Medical Group /ID# 257099
Jefferson City, Missouri, United States, 65109
Actively Recruiting
72
Mercy Research - Springfield /ID# 262385
Springfield, Missouri, United States, 65804
Actively Recruiting
73
St. Louis University /ID# 262375
St Louis, Missouri, United States, 63104
Actively Recruiting
74
Washington University-School of Medicine /ID# 262391
St Louis, Missouri, United States, 63110
Actively Recruiting
75
Billings Clinic /ID# 258316
Billings, Montana, United States, 59101-0733
Actively Recruiting
76
Mercury Street Medical /ID# 259632
Butte, Montana, United States, 59701-1652
Actively Recruiting
77
Bryan Health Pine Lake Campus /ID# 259638
Lincoln, Nebraska, United States, 68516
Actively Recruiting
78
Methodist Physicians Clinic /ID# 259276
Omaha, Nebraska, United States, 68114
Actively Recruiting
79
Palm Research Center /ID# 256131
Las Vegas, Nevada, United States, 89148
Actively Recruiting
80
Northern Nevada Endocrinology /ID# 259646
Reno, Nevada, United States, 89511
Actively Recruiting
81
Southern New Hampshire Diabetes and Endocrinology /ID# 257841
Nashua, New Hampshire, United States, 03060
Actively Recruiting
82
Albany Medical College- Endocrinology Washington Extension /ID# 256794
Albany, New York, United States, 12203
Actively Recruiting
83
Research Foundation of SUNY - University of Buffalo /ID# 261019
Buffalo, New York, United States, 14203
Actively Recruiting
84
NYC Research /ID# 258662
New York, New York, United States, 10001
Actively Recruiting
85
Endocrine Assc Long Island PC /ID# 257357
Smithtown, New York, United States, 11787
Actively Recruiting
86
Physician's East Endocrinology /ID# 256491
Greenville, North Carolina, United States, 27834
Actively Recruiting
87
Carteret Medical Group /ID# 256869
Morehead City, North Carolina, United States, 28557
Actively Recruiting
88
Lucas Research /ID# 256127
Morehead City, North Carolina, United States, 28557
Actively Recruiting
89
Lucas Research /ID# 257061
Morehead City, North Carolina, United States, 28557
Actively Recruiting
90
Accellacare - Salisbury /ID# 257019
Salisbury, North Carolina, United States, 28144-2735
Actively Recruiting
91
Accellacare Wilmington /ID# 256744
Wilmington, North Carolina, United States, 28401
Actively Recruiting
92
Diabetes and Endocrinology Associates of Stark County Inc /ID# 256751
Canton, Ohio, United States, 44718
Actively Recruiting
93
Cleveland Clinic - Cleveland /ID# 262392
Cleveland, Ohio, United States, 44195
Actively Recruiting
94
The Ohio State University Wexner Medical Center - CarePoint East /ID# 264061
Columbus, Ohio, United States, 43203
Actively Recruiting
95
Lynn Institute of Norman /ID# 256785
Norman, Oklahoma, United States, 73072
Actively Recruiting
96
Lynn Institute of Oklahoma City /ID# 263141
Oklahoma City, Oklahoma, United States, 73112
Actively Recruiting
97
Diabetes & Endocrinology Consultants of Pennsylvania /ID# 259064
Feasterville-Trevose, Pennsylvania, United States, 19053
Actively Recruiting
98
Thomas Jefferson University Hospital /ID# 256834
Philadelphia, Pennsylvania, United States, 19107
Actively Recruiting
99
Jefferson Health - Roosevelt Boulevard /ID# 256837
Philadelphia, Pennsylvania, United States, 19114-1025
Actively Recruiting
100
Guthrie Robert Packer Hospital /ID# 261838
Sayre, Pennsylvania, United States, 18840
Actively Recruiting
101
TMA Headlands LLC /ID# 259800
Myrtle Beach, South Carolina, United States, 29572
Actively Recruiting
102
Carolina Endocrine Associates Llc /ID# 259640
North Charleston, South Carolina, United States, 29406-9823
Actively Recruiting
103
Palmetto Clinical Research - Summerville /ID# 258845
Summerville, South Carolina, United States, 29485
Actively Recruiting
104
Chattanooga Medical Research /ID# 257631
Chattanooga, Tennessee, United States, 37404-3239
Actively Recruiting
105
PMG Research of Knoxville /ID# 256854
Knoxville, Tennessee, United States, 37938
Actively Recruiting
106
University of Tennessee Health Science Center /ID# 259825
Memphis, Tennessee, United States, 38103
Actively Recruiting
107
Lifedoc Research /ID# 262975
Memphis, Tennessee, United States, 38115
Actively Recruiting
108
Mid State Endocrine Associates /ID# 259641
Nashville, Tennessee, United States, 37203
Actively Recruiting
109
Texas Diabetes and Endocrinology - Central Austin /ID# 255728
Austin, Texas, United States, 78731
Actively Recruiting
110
Texas Diabetes and Endocrinology - South Austin /ID# 255723
Austin, Texas, United States, 78749
Actively Recruiting
111
Brusco, Corpus Christi, TX /ID# 256746
Corpus Christi, Texas, United States, 78414
Actively Recruiting
112
North TX Endocrine Center /ID# 255737
Dallas, Texas, United States, 75231
Actively Recruiting
113
Research Institute Dallas /ID# 256126
Dallas, Texas, United States, 75231
Completed
114
Academy of Diabetes, Thyroid and Endocrine /ID# 255735
El Paso, Texas, United States, 79935
Actively Recruiting
115
Diabetes and Thyroid Center of Ft. Worth /ID# 256781
Fort Worth, Texas, United States, 76132
Actively Recruiting
116
Juno Research /ID# 259238
Houston, Texas, United States, 77040
Actively Recruiting
117
Biopharma Informatic - Houston - Business Center Drive /ID# 256149
Houston, Texas, United States, 77043
Actively Recruiting
118
PlanIt Research, PLLC /ID# 259221
Houston, Texas, United States, 77079-2204
Actively Recruiting
119
Endocrine and Psychiatry Cente /ID# 259631
Houston, Texas, United States, 77095
Actively Recruiting
120
Tekton Research - Irving /ID# 260988
Irving, Texas, United States, 75039
Actively Recruiting
121
Southern Endocrinology Associates /ID# 256795
Mesquite, Texas, United States, 75149
Actively Recruiting
122
Texas Diabetes and Endocrinology /ID# 255722
Round Rock, Texas, United States, 78681
Actively Recruiting
123
Northeast Clinical Research of San Antonio, LLC /ID# 256868
San Antonio, Texas, United States, 78233
Actively Recruiting
124
Diabetes & Glandular Disease Clinic /ID# 255734
San Antonio, Texas, United States, 78237
Actively Recruiting
125
Consano Clinical Research, LLC /ID# 256138
Shavano Park, Texas, United States, 78231
Actively Recruiting
126
Texas Valley Clinical Research /ID# 261476
Weslaco, Texas, United States, 78596
Actively Recruiting
127
Advanced Research Institute /ID# 259821
Ogden, Utah, United States, 84405-6779
Actively Recruiting
128
The University of Vermont Medical Center /ID# 256533
South Burlington, Vermont, United States, 05403
Actively Recruiting
129
Virginia Endocrinology Research /ID# 259623
Chesapeake, Virginia, United States, 23321
Actively Recruiting
130
Richmond VA Medical Center /ID# 262386
Richmond, Virginia, United States, 23249
Actively Recruiting
131
Salem VA Medical Center /ID# 262387
Salem, Virginia, United States, 24153
Actively Recruiting
132
Rainier Clinical Research /ID# 255802
Renton, Washington, United States, 98055
Actively Recruiting
133
MultiCare Rockwood Clinic /ID# 255951
Spokane, Washington, United States, 99202
Actively Recruiting
134
MultiCare Institute for Research & Innovation /ID# 255954
Tacoma, Washington, United States, 98405
Completed
135
Clinical Research Investigator Group, LLC /ID# 263177
Bayamón, Puerto Rico, 00960
Actively Recruiting
136
ISIS Clinical Research Center /ID# 263182
Guaynabo, Puerto Rico, 00969-2806
Actively Recruiting
137
BRCR Global Puerto Rico /ID# 268231
San Juan, Puerto Rico, 00907-1510
Actively Recruiting
138
GCM Medical Group, PSC /ID# 263183
San Juan, Puerto Rico, 00917
Actively Recruiting
139
Mindful Medical Research /ID# 263184
San Juan, Puerto Rico, 00918-3756
Actively Recruiting
Research Team
A
ABBVIE CALL CENTER
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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