Actively Recruiting
Study of Axial and Cognitive Symptoms and Biomarkers of Neurodegeneration in Brain-first and Body-first PD
Led by Azienda USL Reggio Emilia - IRCCS · Updated on 2026-04-23
150
Participants Needed
1
Research Sites
347 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This observational study aims to systematically characterize a cohort of patients with early-stage Parkinson's disease (PD) attending the Movement Disorders Center of AUSL-IRCCS Reggio Emilia, Italy. PD is the second most common neurodegenerative disorder, affecting about 1% of individuals over 60 years of age. The project will explore clinical and biological differences between the recently proposed "Brain-First" and "Body-First" phenotypes of PD. Patients will undergo detailed clinical evaluation, neuroimaging, and biomarker assessments (including neurodegeneration and neuroinflammation markers). Particular attention will be given to the progression of axial and cognitive symptoms, which represent major contributors to disability. Findings from this study are expected to improve early patient stratification, clarify disease mechanisms, and support the development of precision medicine strategies and future disease-modifying therapies.
CONDITIONS
Official Title
Study of Axial and Cognitive Symptoms and Biomarkers of Neurodegeneration in Brain-first and Body-first PD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with Parkinson's disease according to MDS Clinical Diagnostic Criteria and classified as brain-first or body-first phenotype based on REM sleep behavior disorder and imaging data
- Able to provide free and informed consent
- At least 18 years of age
You will not qualify if you...
- Unable to provide free and informed consent
- Diagnosis of Parkinson's disease is doubtful
- Under 18 years of age
AI-Screening
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Trial Site Locations
Total: 1 location
1
Azienda USL IRCCS di Reggio Emilia
Reggio Emilia, Italy
Actively Recruiting
Research Team
F
Francesco Cavallieri, MD
CONTACT
S
Stefania Croci, BSc
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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