Actively Recruiting

Phase 3
Age: 1Year - 17Years
All Genders
NCT04088396

A Study of Baricitinib (LY3009104) in Participants From 1 Year to Less Than 18 Years Old With Systemic Juvenile Idiopathic Arthritis (sJIA)

Led by Eli Lilly and Company · Updated on 2026-02-10

58

Participants Needed

55

Research Sites

341 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The reason for this study is to see if the study drug baricitinib is safe and effective in participants from 1 year to less than 18 years old with systemic juvenile idiopathic arthritis (sJIA). Participants are assigned to 1 of 2 cohorts. In cohort 1, participants will receive baricitinib or tocilizumab reference. In cohort 2, participants will receive baricitinib.

CONDITIONS

Official Title

A Study of Baricitinib (LY3009104) in Participants From 1 Year to Less Than 18 Years Old With Systemic Juvenile Idiopathic Arthritis (sJIA)

Who Can Participate

Age: 1Year - 17Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Diagnosis of systemic juvenile idiopathic arthritis (sJIA) with onset before age 16
  • At least 2 active joints at screening and baseline
  • For Cohort 1: Participants aged 1 to less than 18 years, IL-6 inhibitor therapy naive (except in countries restricting tocilizumab use under 2 years)
  • For Cohort 2: Participants aged 1 to less than 18 years
Not Eligible

You will not qualify if you...

  • Diagnosis of polyarticular JIA (rheumatoid factor positive or negative), extended oligoarticular JIA, enthesitis-related JIA, or juvenile psoriatic arthritis
  • Persistent oligoarticular arthritis as defined by ILAR criteria
  • History or presence of any autoimmune inflammatory condition other than JIA
  • Active anterior uveitis or receiving treatment for anterior uveitis
  • Active fibromyalgia or other chronic pain conditions affecting disease assessment
  • Biologic features of Macrophage Activation Syndrome (MAS) in past 12 weeks
  • Current or recent (less than 4 weeks prior to baseline) serious infection
  • Positive test for hepatitis B virus
  • Evidence of active or untreated latent tuberculosis (TB)

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 55 locations

1

Instituto CAICI SRL

Rosario, Argentina, S2000

Actively Recruiting

2

Centro Medico Privado de Reumatologia

SAN M. de Tucuman, Argentina, T4000AXL

Actively Recruiting

3

UZ Gent

Ghent, Belgium, 9000

Actively Recruiting

4

Faculdade de Medicina da UNESP

Botucatu, Brazil, 18618-686

Actively Recruiting

5

Hospital de Clinicas de Porto Alegre

Porto Alegre, Brazil, 90035-903

Actively Recruiting

6

IPITEC

São Paulo, Brazil, 01221-020

Not Yet Recruiting

7

Universidade Federal de Sao Paulo

São Paulo, Brazil, 04024-001

Actively Recruiting

8

Instituto da Crianca do Hospital das Clinicas da FMUSP

São Paulo, Brazil, 05403-000

Actively Recruiting

9

Detska nemocnice FN Brno

Brno, Czechia, 613 00

Actively Recruiting

10

Vseobecna fakultni nemocnice v Praze

Prague, Czechia, 12808

Actively Recruiting

11

Hospices Civils de Lyon - Hôpital Femme Mère Enfant

Bron, France, 69500

Actively Recruiting

12

Hôpitaux Universitaires Paris Sud - Hôpital Bicêtre

Le Kremlin-Bicêtre, France, 94270

Actively Recruiting

13

Centre Hospitalier Universitaire de Nîmes - Hôpital Universitaire Carémeau

Nîmes, France, 30029

Actively Recruiting

14

Hôpital Universitaire Necker Enfants Malades

Paris, France, 75015

Actively Recruiting

15

Centre Hospitalier Universitaire de Poitiers

Poitiers, France, 86021

Actively Recruiting

16

Sir Ganga Ram Hospital

New Delhi, India, 110060

Actively Recruiting

17

Meir Medical Center

Kfar Saba, Israel, 4428164

Actively Recruiting

18

Schneider Children's Medical Center

Petah Tikva, Israel, 49202

Actively Recruiting

19

Sheba Medical Center

Ramat Gan, Israel, 5262100

Actively Recruiting

20

Azienda Ospedaliera Spedali Civili di Brescia

Brescia, Italy, 25123

Actively Recruiting

21

Azienda Sanitaria Locale n. 2 - Lanciano Vasto Chieti

Chieti, Italy, 66100

Completed

22

IRCCS Istituto Giannina Gaslini

Genova, Italy, 16147

Actively Recruiting

23

Centro Specialistico Ortopedico Traumatologico Gaetano Pini - CTO

Milan, Italy, 20122

Actively Recruiting

24

Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico

Milan, Italy, 20122

Completed

25

University of Naples Federico II

Naples, Italy, 80131

Actively Recruiting

26

Azienda di Rilievo Nazionale e Alta Specializzazione Civico Di Cristina Benfratelli

Palermo, Italy, 90127

Actively Recruiting

27

Ospedale Infantile Burlo Garofolo

Trieste, Italy, 34137

Actively Recruiting

28

Institute of Science Tokyo Hospital

Bunkyō, Japan, 113-8510

Actively Recruiting

29

Chiba Children's Hospital

Chiba, Japan, 266-0007

Actively Recruiting

30

Kagoshima University Hospital

Kagoshima, Japan, 890-8520

Actively Recruiting

31

Miyagi Children's Hospital

Sendai, Japan, 989-3126

Actively Recruiting

32

Osaka Medical and Pharmaceutical University Hospital

Takatsuki, Japan, 569-8686

Actively Recruiting

33

Kanagawa Children's Medical Center

Yokohama, Japan, 232-8555

Actively Recruiting

34

Yokohama City University Hospital

Yokohama, Japan, 236-0004

Actively Recruiting

35

Investigacion y Biomedicina de Chihuahua

Chihuahua City, Mexico, 31000

Actively Recruiting

36

Instituto de Investigaciones Clínicas para la Salud

Durango, Mexico, 34000

Actively Recruiting

37

Crea de Guadalajara

Guadalajara, Mexico, 44600

Actively Recruiting

38

Clinstile, S.A. de C.V.

México, Mexico, 06700

Actively Recruiting

39

Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León

Monterrey, Mexico, 66460

Actively Recruiting

40

Wojewódzki Specjalistyczny Szpital Dziecięcy im. św. Ludwika w Krakowie

Krakow, Poland, 31-503

Actively Recruiting

41

Centralny Szpital Kliniczny Uniwersytetu Medycznego w Lodzi

Lodz, Poland, 91-738

Actively Recruiting

42

Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji

Warsaw, Poland, 02-637

Actively Recruiting

43

Hospital Sant Joan de Déu

Esplugues de Llobregat, Spain, 08950

Actively Recruiting

44

Hospital Infantil Universitario Niño Jesús

Madrid, Spain, 28009

Actively Recruiting

45

Hospital Universitario Ramón y Cajal

Madrid, Spain, 28034

Actively Recruiting

46

Hospital Universitario La Paz

Madrid, Spain, 28046

Actively Recruiting

47

Hospital Universitario Virgen Del Rocio

Seville, Spain, 41013

Actively Recruiting

48

Hospital Universitari i Politecnic La Fe

Valencia, Spain, 46026

Actively Recruiting

49

Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine

Istanbul, Turkey (Türkiye), 34098

Actively Recruiting

50

9 Eylul University Hospital

Izmir, Turkey (Türkiye), 35340

Actively Recruiting

51

Bristol Royal Hospital for Children

Bristol, United Kingdom, BS2 8BJ

Actively Recruiting

52

Alder Hey Children's Hospital

Liverpool, United Kingdom, L12 2AB

Actively Recruiting

53

Great Ormond Street Hospital For Children NHS Foundation Trust

London, United Kingdom, WC1N 3JH

Completed

54

Oxford University Hospitals - Nuffield Orthopaedic Centre

Oxford, United Kingdom, OX3 7HE

Actively Recruiting

55

Sheffield Children's Hospital

Sheffield, United Kingdom, S10 2TH

Actively Recruiting

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Research Team

T

Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or

CONTACT

P

Physicians interested in becoming principal investigators please contact

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

3

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