Actively Recruiting

Age: 18Years +
All Genders
NCT06686615

A Study of Bempedoic Acid in Combination With Ezetimibe and Either Rosuvastatin or Atorvastatin in Patients With Primary Hypercholesterolemia or Mixed Dyslipidemia

Led by Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company · Updated on 2026-05-08

2000

Participants Needed

163

Research Sites

154 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Data on the real-world use and effectiveness and safety of bempedoic acid combined with both a statin and ezetimibe in clinical practice is limited. There is an increased focus on using combination therapy to lower LDL-C.

CONDITIONS

Official Title

A Study of Bempedoic Acid in Combination With Ezetimibe and Either Rosuvastatin or Atorvastatin in Patients With Primary Hypercholesterolemia or Mixed Dyslipidemia

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Provide written informed consent to participate
  • Be at least 18 years old
  • Be a high or very high cardiovascular risk patient with documented primary hypercholesterolemia or mixed dyslipidemia at the start of bempedoic acid treatment
  • Be treated with bempedoic acid combined with ezetimibe and rosuvastatin or atorvastatin in any sequence or simultaneously
  • Have started triple therapy within four weeks before inclusion
  • Have an untreated LDL-C value available from within the past 5 years before starting triple therapy
  • Have no contraindications to bempedoic acid, statin, or ezetimibe as assessed by a physician
  • Not be participating in any interventional study (non-interventional study participation allowed)
  • Have a life expectancy greater than 1 year
Not Eligible

You will not qualify if you...

  • Received PCSK9 inhibitor monoclonal antibody treatment within 3 months before starting triple therapy
  • Ever received PCSK9 inhibitor small interfering RNA (siRNA) treatment

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 163 locations

1

Innere Medizin

Braunau am Inn, Austria, 5280

Actively Recruiting

2

Innere Medizin 1

Feldkirch, Austria, 6800

Actively Recruiting

3

Uniklinik Graz, Endokrinologie und Diabetes

Graz, Austria, 8036

Actively Recruiting

4

Uniklinik Graz, Kardiologie

Graz, Austria, 8036

Actively Recruiting

5

Innere Medizin 3 - Kardiologie

Innsbruck, Austria, 6020

Actively Recruiting

6

Klinikum Wels-Grieskirchen GmbH+B18

Kepler Universitätsklinikum Gmb+, Austria, 4600

Active, Not Recruiting

7

Innere Medizin

Klagenfurt, Austria, 9020

Actively Recruiting

8

Innere Medizin

Linz, Austria, 4020

Actively Recruiting

9

Kepler Universitätsklinikum GmbH Klinik für Innere Medizin 1 - Kardiologie und Internistische Intensivmedizin

Linz, Austria, 4021

Actively Recruiting

10

Kardiologie-Urfahr Dr. Hönig & Dr. Gammer & Dr. Buchmayr

Linz, Austria, 4040

Actively Recruiting

11

Ordination

Mattersburg, Austria, 7210

Actively Recruiting

12

Landesklinikum Mistelbach - Gänserndorf

Mistelbach, Austria, 2130

Active, Not Recruiting

13

Ordination Dr. med. univ. Evelyn Fließer-Görzer

Saint Stefan Bei Graz, Austria, 8511

Actively Recruiting

14

Praxis Gesundheitszentrum Moos 15 (Praxis Prof. Lichtenauer)

Salzburg, Austria, 5020

Actively Recruiting

15

DOZ (Dialyse- und Ordinationszentrum) Privatklinik Wehrle-Diakonissen

Salzburg, Austria, 5026

Actively Recruiting

16

Klinik Landstrasse, Kardiologie

Vienna, Austria, 1030

Actively Recruiting

17

Ordination Univ.-Prof. Dr. Kurt Huber

Vienna, Austria, 1060

Active, Not Recruiting

18

Zentrum für Klinische Studien Dr. Hanusch GmbH

Vienna, Austria, 1060

Active, Not Recruiting

19

AKH Wien

Vienna, Austria, 1090

Actively Recruiting

20

Meduni Wien, Endokrinologie und Diabetes

Vienna, Austria, 1090

Actively Recruiting

21

Meduni Wien, Kardiologie

Vienna, Austria, 1090

Actively Recruiting

22

Clinic Hietzing

Vienna, Austria, 1130

Actively Recruiting

23

Herzzentrum 18

Vienna, Austria, 1180

Actively Recruiting

24

Karl Landsteiner Institut für kardiovaskuläre und intensivmedizinische Forschung c/o Abteilung für Kardiologie, Klinik Floridsdorf

Vienna, Austria, 1210

Actively Recruiting

25

Azorg

Aalst, Belgium, 9300

Actively Recruiting

26

UZA (Antwerp University Hospital)

Antwerp, Belgium, 2650

Active, Not Recruiting

27

Epicure Hornu

Boussu, Belgium, 7301

Actively Recruiting

28

A.Z. KLINA Brasschaat

Brasschaat, Belgium, 2930

Actively Recruiting

29

Algemeen Ziekenhuis Sint-Jan Oostende

Bruges, Belgium, 8400

Actively Recruiting

30

CHU Brugman

Brussels, Belgium, 1020

Active, Not Recruiting

31

UZ Brussel

Brussels, Belgium, 1090

Active, Not Recruiting

32

CHU Charleroi Hopital civil Marie-Curie

Charleroi, Belgium, 6042

Actively Recruiting

33

GHDC Charleroi - Site Hôpital Saint-Joseph

Charleroi, Belgium, 6060

Actively Recruiting

34

Z.O.L - Campus St. Jan

Genk, Belgium, 3600

Actively Recruiting

35

Az Sint Lucas

Ghent, Belgium, 9000

Active, Not Recruiting

36

UZ Gent

Ghent, Belgium, 9000

Active, Not Recruiting

37

CHR Huy

Huy, Belgium, 4500

Active, Not Recruiting

38

AZ Groeninge Kortrijk

Kortrijk, Belgium, 8500

Actively Recruiting

39

Pôle hospitalier Jolimont

La Louvrière, Belgium, 7100

Actively Recruiting

40

JAN YPERMAN Ziekenhuis

Leper, Belgium, 8900

Actively Recruiting

41

UZ Leuven

Leuven, Belgium, 3000

Actively Recruiting

42

CHR Citadelle de Liège

Liège, Belgium, 4000

Active, Not Recruiting

43

CHU Mons Ambroise Paré

Mons, Belgium, 7000

Active, Not Recruiting

44

AZ Delta

Roeselare, Belgium, 8800

Actively Recruiting

45

AZ Glorieux

Ronse, Belgium, 9600

Actively Recruiting

46

CHU UCL Mont-Godinne

Yvoir, Belgium, 5530

Actively Recruiting

47

Praxis für Kardiologie Aachen

Aachen, Germany, 52062

Actively Recruiting

48

Klinikum Ahaus

Ahaus, Germany, 48683

Actively Recruiting

49

Praxis W. Almohamed

Alsfed, Germany, 36304

Actively Recruiting

50

Zentrum für klinische Studien Bad Homburg

Bad Homburg, Germany, 61348

Actively Recruiting

51

Dialysezentrum Hellersdorf Mitte

Berlin, Germany, 12627

Actively Recruiting

52

Lipidambulanz Charite Campus Virchow

Berlin, Germany, 13353

Actively Recruiting

53

MEDICLIN Reha-Zentrum Spreewald

Burg, Germany, 03096

Actively Recruiting

54

Kardiologische Gemeinschaftspraxis Flemmingstr.

Chemnitz, Germany, 09116

Actively Recruiting

55

Klinik Detmold

Detmold, Germany, 32756

Actively Recruiting

56

Praxis Dr. Methfessel

Dresden, Germany, 01159

Actively Recruiting

57

Cardiologicum Dresden

Dresden, Germany, 01796

Actively Recruiting

58

Herz- und Gefäßmedizin Goslar

Goslar, Germany, 38640

Actively Recruiting

59

ndgl.; viele Kombinationstherapien

Gräfenhainichen, Germany, 06773

Active, Not Recruiting

60

Praxis

Greiz, Germany, 07973

Actively Recruiting

61

Kardiologie am Tibarg

Hamburg, Germany, 22459

Actively Recruiting

62

Jessa Ziekenhuis

Hasselt, Germany, 3500

Actively Recruiting

63

HPK Heidelberger Praxisklinik

Heidelberg, Germany, 69115

Actively Recruiting

64

Uni-Klinik Heidelberg

Heidelberg, Germany, 69120

Actively Recruiting

65

Kardiopraxis

Kaiserslautern, Germany, 67655

Actively Recruiting

66

GK Mittelrhein

Koblenz, Germany, 56073

Actively Recruiting

67

Klinikum Konstanz

Konstanz, Germany, 78464

Actively Recruiting

68

Universitätsklinikum Leipzig

Leipzig, Germany, 04103

Actively Recruiting

69

DRK Krankenhaus Lichtenstein Gemeinnützige GmbH

Lichtenstein, Germany, 09350

Actively Recruiting

70

Cardio Centrum Ludwigsburg

Ludwigsburg, Germany, 71634

Actively Recruiting

71

Kardiopraxis

Mainz, Germany, 55122

Actively Recruiting

72

Kardiologische Praxis Markkleeberg

Markkleeberg, Germany, 04416

Actively Recruiting

73

Kardiologie Gem. Praxis Dres Reiff/Linse/Haj-Yehia/Specking

Moers, Germany, 47441

Actively Recruiting

74

Praxis Dr. Norbert Schön

Mühldorf A. Inn, Germany, 84453

Actively Recruiting

75

Kardiologische Gemeinschaftpraxis Papenburg

Papenburg, Germany, 26871

Actively Recruiting

76

Kardiologische Gemeinschaftspraxis Papenburg

Papenburg, Germany, 26871

Actively Recruiting

77

Hausärztlich-kardiologisches MVZ,,Am Felsenkeller" GmbH

Pirna, Germany, 01796

Actively Recruiting

78

Kardiologische Gemeinschaftspraxis am Park Sanssouci

Potsdam, Germany, 14469

Actively Recruiting

79

Lipidambulanz Uniklinikum Regensburg

Regensburg, Germany, 93053

Actively Recruiting

80

Parkkardiologie, kard. Gemeinschaftspraxis

Stanhsdorf B. Berlin, Germany, 14532

Actively Recruiting

81

BBT Trier

Trier, Germany, 54292

Active, Not Recruiting

82

Diabetologische Schwerpunktpraxis

Trier, Germany, 54292

Actively Recruiting

83

Herzklinik

Ulm, Germany, 89077

Actively Recruiting

84

Dialysezentrum Hofaue

Wuppertal, Germany, 42103

Active, Not Recruiting

85

Ente Ecclesiastico "Miulli"

Acquaviva delle Fonti, Italy, 70021

Actively Recruiting

86

INRCA

Ancona, Italy, 60127

Actively Recruiting

87

AO Moscati

Avellino, Italy, 83100

Actively Recruiting

88

Osp. "San Paolo"

Bari, Italy, 70123

Actively Recruiting

89

Ospedale di Bolzano

Bolzano, Italy, 39100

Actively Recruiting

90

Spedali Civili di Brescia

Brescia, Italy, 25123

Actively Recruiting

91

Osp. santo spirito

Casale Monferrato, Italy, 15033

Actively Recruiting

92

Ospedale Sant'Anna e san Sebastiano

Caserta, Italy, 81100

Actively Recruiting

93

Policlinnico Mater Domini

Catanzaro, Italy, 88100

Active, Not Recruiting

94

Osp. SS Annunziata

Chieti, Italy, 66100

Actively Recruiting

95

PO Nuovo Umberti I

Enna, Italy, 94100

Actively Recruiting

96

Osp. Sant'Anna di Cona

Ferrara, Italy, 44124

Actively Recruiting

97

Policlinico "Riuniti"

Foggia, Italy, 71122

Actively Recruiting

98

Policlinico San Martino

Genova, Italy, 16132

Actively Recruiting

99

Osp della Misericordia

Grosseto, Italy, 58100

Actively Recruiting

100

Osp. "Vito Fazzi"

Lecce, Italy, 73100

Actively Recruiting

101

Ospedale Mater Salutis

Legnagno, Italy, 37045

Actively Recruiting

102

Spedali Riuniti

Livorno, Italy, 57124

Actively Recruiting

103

Ospedale di Mantova

Mantua, Italy, 46100

Actively Recruiting

104

Policlinico G. Martino

Messina, Italy, 98124

Actively Recruiting

105

IRCCS Monzino

Milan, Italy, 20138

Actively Recruiting

106

IRCCS Galeazzi Sant'Ambrogio

Milan, Italy, 20157

Actively Recruiting

107

Policlinico Modena

Modena, Italy, 41125

Actively Recruiting

108

AO Cardarelli

Naples, Italy, 80131

Actively Recruiting

109

Policlinico Federico II

Naples, Italy, 80131

Actively Recruiting

110

AOU Vanvitelli, I Policlinico

Naples, Italy, 80138

Actively Recruiting

111

Policlinico P. Giaccone

Palermo, Italy, 90127

Actively Recruiting

112

ICS Maugeri

Pavi, Italy, 27100

Actively Recruiting

113

S. Maria della Misericordia

Perugia, Italy, 06129

Actively Recruiting

114

Presidio Ospedaliero

Pescara, Italy, 65124

Actively Recruiting

115

Ospedale PederzoliItlit

Peschiera, Italy, 37019

Actively Recruiting

116

Cisanello

Pisa, Italy, 56124

Actively Recruiting

117

Osp. Santa Maria delle Croci

Ravenna, Italy, 48121

Actively Recruiting

118

Osp infermi di rivoli

Rivoli, Italy, 10098

Actively Recruiting

119

Policlinico Tor Vergata

Roma, Italy, 00133

Actively Recruiting

120

Ospedale Pertini

Roma, Italy, 00157

Actively Recruiting

121

Ospedale Sant'Andrea

Roma, Italy, 00189

Actively Recruiting

122

Policlinico Umberto I

Rome, Italy, 00161

Actively Recruiting

123

Molinette Università to

Torino, Italy, 10126

Actively Recruiting

124

Ospedale Mauriziano

Torino, Italy, 10128

Actively Recruiting

125

Osp. di Cattinara

Trieste, Italy, 34149

Actively Recruiting

126

Ospedale di Portogruaro

Venezia, Italy, 30026

Actively Recruiting

127

AOUI Verona

Verona, Italy, 37126

Actively Recruiting

128

H. Univers. De Albacete

Albacete, Spain, 02006

Actively Recruiting

129

Hospital General Universitario Dr. Balmis

Alicante, Spain, 03010

Actively Recruiting

130

H. General de Elche

Alicante, Spain, 03203

Actively Recruiting

131

Hospital Universitario de San Juan

Alicante, Spain, 03550

Actively Recruiting

132

Hospital Universitario de Cruces

Barakaldo, Spain, 48903

Actively Recruiting

133

Hospital Universitario de Burgos

Burgos, Spain, 09006

Actively Recruiting

134

H. Univ. Puerta del Mar

Cadiz, Spain, 11009

Actively Recruiting

135

H. Punta de Europa

Cadiz, Spain, 11207

Actively Recruiting

136

Hospital Universitario Puerto Real

Cadiz, Spain, 11510

Actively Recruiting

137

Sierrallana Hospital

Cantabria, Spain, 39300

Actively Recruiting

138

H. Univ. Reina Sofía

Córdoba, Spain, 14004

Active, Not Recruiting

139

Hospital Universitario de Donostia

Donostia / San Sebastian, Spain, 20014

Active, Not Recruiting

140

H. Univ. De Cabueñes

Gijón, Spain, 33394

Actively Recruiting

141

H. Virgen de las Nieves

Granada, Spain, 18014

Actively Recruiting

142

H. Juan Ramón Jiménez

Huelva, Spain, 21005

Actively Recruiting

143

Hospital Universitario Médico-Quirúrgico de Jaén

Jaén, Spain, 23007

Actively Recruiting

144

Hospital Universitario de Gran Canarias Dr. Negrín

Las Palmas de GC, Spain, 35010

Actively Recruiting

145

Hospital de León

León, Spain, 24008

Actively Recruiting

146

Hospital San Pedro

Logroño, Spain, 26006

Actively Recruiting

147

H. Costa del Sol

Marbella (Málaga), Spain, 29603

Actively Recruiting

148

H. Virgen de la Victoria

Málaga, Spain, 29010

Actively Recruiting

149

Hospital Serranía de Ronda

Málaga, Spain, 29400

Actively Recruiting

150

Hospital General Universitario Reina Sofía

Murcia, Spain, 30003

Active, Not Recruiting

151

H. Virgen de la Arrixaca

Murcia, Spain, 30120

Actively Recruiting

152

Hospital Universitario Central de Asturias

Oviedo, Spain, 33011

Actively Recruiting

153

Hospital Universitario Son LLatzer

Palma de Mallorca, Spain, 07198

Actively Recruiting

154

Clínica Universidad de Navarra

Pamplona, Spain, 31008

Actively Recruiting

155

Hospital Universitario de Navarra

Pamplona, Spain, 31008

Actively Recruiting

156

Hospital Universitario de Canarias

Santa Cruz de Tenerife, Spain, 38320

Actively Recruiting

157

Hospital de Segovia

Segovia, Spain, 40002

Actively Recruiting

158

Hospital General Universitario de Toledo

Toledo, Spain, 45007

Active, Not Recruiting

159

H. Clínico Univ. De Valencia

Valencia, Spain, 46010

Active, Not Recruiting

160

Consorcio Hospital General Univ de Valencia

Valencia, Spain, 46014

Actively Recruiting

161

Hospital La Fe

Valencia, Spain, 46026

Actively Recruiting

162

Hospital Universitario de Álava

Vitoria-Gasteiz, Spain, 01009

Actively Recruiting

163

Hospital Clinico Universitaro Lozano Blesa

Zaragoza, Spain, 50009

Active, Not Recruiting

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Research Team

D

Daiichi Sankyo Contact for Clinical Trial Information

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

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