Actively Recruiting
A Study of BIO 300 and Thoracic Radiation Therapy in People With Non-Small Cell Lung Cancer and Interstitial Lung Disease
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-03-03
25
Participants Needed
7
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study to find out whether giving BIO 300 in combination with thoracic radiation therapy is effective in preventing pneumonitis in people with non-small cell lung cancer (NSCLC) and interstitial lung disease (ILD).
CONDITIONS
Official Title
A Study of BIO 300 and Thoracic Radiation Therapy in People With Non-Small Cell Lung Cancer and Interstitial Lung Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able to give signed informed consent and follow study requirements
- Age 18 years or older at time of consent
- Stage I or II non-small cell lung cancer diagnosed by pathology or clinical evidence
- Diagnosed with interstitial lung disease by a lung specialist or based on imaging and lung function
- ECOG performance status between 0 and 3
- Women must be post-menopausal or have a negative pregnancy test if pre-menopausal
- Life expectancy of at least 6 months
You will not qualify if you...
- Previous thoracic radiation treatment
- History of pneumonectomy (lung removal surgery)
- Major surgery within 28 days before joining the study
- Serious illness that would prevent completing radiation or study procedures
- Known allergy to study drugs or ingredients
- Hospitalization for worsening ILD in the last 30 days
- Poorly controlled heart rhythm problems or use of a pacemaker
- Pregnant or breastfeeding women, or those not using highly effective contraception
- Use of investigational cancer therapies or planned chemotherapy/immunotherapy during the study
- Use of immune system-targeting biologic drugs planned concurrently with BIO 300
AI-Screening
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Trial Site Locations
Total: 7 locations
1
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
2
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)
Middletown, New Jersey, United States, 07748
Actively Recruiting
3
Memorial Sloan Kettering Bergen (Limited Protocol Activities)
Montvale, New Jersey, United States, 07645
Actively Recruiting
4
Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities)
Commack, New York, United States, 11725
Actively Recruiting
5
Memorial Sloan Kettering Westchester (Limited Protocol Activities)
Harrison, New York, United States, 10604
Actively Recruiting
6
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, New York, United States, 10065
Actively Recruiting
7
Memorial Sloan Kettering Nassau (Limited Protocol Activities)
Uniondale, New York, United States, 11553
Actively Recruiting
Research Team
N
Narek Shaverdian, MD
CONTACT
J
Jamie Chaft, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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