Actively Recruiting
Study of Biodistribution, Metabolism, Excretion and Brain Uptake11C-M503
Led by University of Pennsylvania · Updated on 2026-04-24
70
Participants Needed
3
Research Sites
258 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The current protocol is to determine the biodistribution, metabolism, excretion and brain uptake of 11C-M503. The goal of this radiotracer is to quantify alpha-synuclein that is abnormally deposited in the brain of people with Parkinson's disease (PD). Investigators will compare uptake in participants with PD versus participants with multiple system atrophy (MSA) and progressive supranuclear palsy (PSP), as well as non-Parkinsonism volunteers. This multicenter project funded by an NIH U19 grant, is centered at U Pennsylvania (Penn, Grant PI: Robert Mach) in collaboration with U Pittsburgh (Pitt) (non-clinical site) Yale U, U of California at San Francisco (UCSF) and Washington University in St. Louis (WU). The University of Pennsylvania will act as the sIRB for this multi-center human subjects project and participants will be recruited from all sites.
CONDITIONS
Official Title
Study of Biodistribution, Metabolism, Excretion and Brain Uptake11C-M503
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 40 to 85 years
- Willing to provide informed consent or have a designated study partner for consent and visits
- Clinical diagnosis of Parkinson's disease, multiple system atrophy, progressive supranuclear palsy, or healthy control confirmed by consensus
- Participants with PD, MSA, or PSP asked to agree to brain donation (optional)
You will not qualify if you...
- Pregnant or breastfeeding females; pregnancy test required for women of child-bearing potential
- Parkinsonism forms other than PD, PSP, or MSA
- Major psychiatric disorders such as schizophrenia or bipolar disorder (major depressive disorder allowed)
- History of significant or ongoing alcohol or substance abuse
- Contraindications or inability to tolerate imaging, arterial line or IV placement, or blood draws
- Contraindications to MRI such as non-compatible implanted medical devices
- Any medical condition or illness deemed by a physician to compromise safety or study participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Yale New Haven Hospital
New Haven, Connecticut, United States, 06510
Actively Recruiting
2
Washington University in St. Louis
St Louis, Missouri, United States, 63110
Actively Recruiting
3
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
E
Erin Schubert
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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