Actively Recruiting
Study on Biomarkers for Early Diagnosis of Alzheimer's Disease
Led by Capital Medical University · Updated on 2026-03-23
6000
Participants Needed
1
Research Sites
369 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The project of Bio-AD is a population- based cohort study among the elderly in China. The project includes not only Alzheimer's disease (AD including familial AD and sporadic AD), but also other clinical stage of AD, as well as elderly people with normal cognitive function. The project will collect, detect and screen the special biomarkers at different clinical stage of AD based on body fluid, gene and brain image. The standard and consistent assessment protocols are employed to obtain clinical, cognitive, genetic, neuroimaging and biospecimen data. The purpose of this project is to establish a panel of biomarkers which could be used to diagnose AD at the early stage, and to establish a risk prediction models for AD to predict the 5-years risk of the onset and progression of AD among elderly population in China.
CONDITIONS
Official Title
Study on Biomarkers for Early Diagnosis of Alzheimer's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Written informed consent obtained from participant or legal guardian prior to any study-related procedures.
- Aged 18 (inclusive) or older.
- Diagnosis of Alzheimer's disease using NINCDS-ADRDA or NIA-AA criteria.
- Diagnosis of mild cognitive impairment (MCI) according to Petersen criteria.
- Diagnosis of pre-MCI group by b2-Amyloid positive or APOE b54 carrier or cognitive complaints without MCI.
- Normal cognitive function assessed by MMSE, CDR, and other cognitive function scales.
- Willing to follow up for 5 years and provide information annually.
You will not qualify if you...
- Under age 18.
- Medical or psychiatric illness interfering with completing initial and follow-up visits.
- No available study informant.
- Current or past neurological or psychiatric illnesses such as schizophrenia, epilepsy, brain tumors, severe head trauma, or other diseases causing dementia.
- Refusal to complete cognitive tests or provide biospecimens.
- History of alcohol or drug abuse.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Xuanwu Hospital of Capital Medical University
Beijing, Beijing Municipality, China, 100053
Actively Recruiting
Research Team
J
Jianping Jia, Doctor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
5
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