Actively Recruiting
A Study of Blood Based Biomarkers for Pancreas Adenocarcinoma
Led by Memorial Sloan Kettering Cancer Center · Updated on 2025-12-02
700
Participants Needed
13
Research Sites
469 weeks
Total Duration
On this page
Sponsors
M
Memorial Sloan Kettering Cancer Center
Lead Sponsor
S
Sheba Medical Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to develop a minimally invasive test to diagnose pancreatic cancer at early stages of disease and monitor response to treatment.
CONDITIONS
Official Title
A Study of Blood Based Biomarkers for Pancreas Adenocarcinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Confirmed diagnosis of locally advanced or metastatic pancreatic adenocarcinoma for Cohort 1
- Planning to receive systemic treatment for Cohort 1
- Hemoglobin level greater than 8 for Cohorts 1 to 4
- ECOG performance status between 0 and 2 for Cohorts 1 to 4
- Willing to undergo tumor biopsy and provide permission for banked tumor tissue for Cohorts 1 and 2
- Confirmed diagnosis of pancreatic adenocarcinoma planned for upfront resection for Cohort 2
- No planned pre-operative systemic or chemoradiation therapy for Cohort 2
- Confirmed diagnosis of acute pancreatitis or other acute pancreatic pathology for Cohort 3
- Confirmed diagnosis of chronic pancreatitis or other non-cystic chronic pancreatic pathology for Cohort 4
- Confirmed diagnosis of IPMN without high-risk features for Cohort 5
- Confirmed diagnosis of benign pancreatic cyst for Cohort 6
- Healthy adults aged 18 or older for Cohort 7
You will not qualify if you...
- Prior chemotherapy or radiation for pancreatic cancer within 3 months for Cohort 1
- Active second malignancy unless low grade for Cohorts 1 and 2
- Planned neoadjuvant chemotherapy or radiation therapy for Cohort 2
- Active or prior malignancy except prior non-melanoma skin cancer for Cohorts 3 to 7
- IPMN with high-risk features or planned resection for Cohort 5
- Proven carrier of a cancer susceptibility gene or concerning family history for Cohorts 3 to 7
- Any medical or psychiatric condition interfering with protocol compliance for all cohorts
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 13 locations
1
Memorial Sloan Kettering Monmouth (All protocol activities)
Middletown, New Jersey, United States, 07748
Actively Recruiting
2
Memorial Sloan Kettering Bergen (All protocol activities)
Montvale, New Jersey, United States, 07645
Actively Recruiting
3
Cold Springs Harbor Laboratory (Specimen Analysis)
Cold Spring Harbor, New York, United States, 11724
Not Yet Recruiting
4
Memorial Sloan Kettering Cancer Center @ Commack (All Protocol Activities)
Commack, New York, United States, 11725
Actively Recruiting
5
Memorial Sloan Kettering Westchester (All protocol activities)
Harrison, New York, United States, 10604
Actively Recruiting
6
New York University
New York, New York, United States, 10010
Active, Not Recruiting
7
Memorial Sloan - Kettering Cancer Center
New York, New York, United States, 10021
Actively Recruiting
8
Memorial Sloan Kettering Basking Ridge (All protocol activities)
New York, New York, United States, 10065
Actively Recruiting
9
Weill Cornell Medical Center
New York, New York, United States, 10065
Not Yet Recruiting
10
Memorial Sloan Kettering Nassau (All protocol activities)
Rockville Centre, New York, United States, 11553
Actively Recruiting
11
Sha'are Zedek Medical Center
Jerusalem, Israel, 91031
Not Yet Recruiting
12
Weizmann Institute of Science
Rehovot, Israel
Not Yet Recruiting
13
Sheba Medical Center
Tel Litwinsky, Israel
Actively Recruiting
Research Team
K
Kenneth Yu, MD
CONTACT
D
David Kelson, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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