Actively Recruiting
A Study of Blood Pressure Control During Cancer Treatment
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-05-14
130
Participants Needed
7
Research Sites
301 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study to find out whether an intensive approach to treating high blood pressure during breast cancer treatment is safe and more effective than standard blood pressure treatment at lowering blood pressure levels and the risk of cardiotoxicity in patients with cancer. Other studies have shown lowering blood pressure improves the health of patients. However, these studies have not included people with cancer. The PROTECT trial is testing a treatment strategy regarding intensive versus standard SBP goals, and is not testing specific medications.
CONDITIONS
Official Title
A Study of Blood Pressure Control During Cancer Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Female assigned at birth
- Biopsy-proven breast cancer (stage I-IV)
- Planned treatment with at least 2 cycles of anthracycline-based chemotherapy (with or without HER2-targeted therapy)
- Systolic blood pressure of 130 mm Hg or higher
- Willing and able to follow the study requirements
- Must have and be willing to use a Bluetooth-enabled WiFi or cellular mobile device
- For CPET subgroup: able to complete acceptable baseline cardiopulmonary exercise test without high-risk findings or inappropriate exercise response
You will not qualify if you...
- Estimated glomerular filtration rate (eGFR) below 30 ml/min/1.73m2
- Arm circumference too large for accurate blood pressure measurement with available devices
- Unable to accurately measure blood pressure in at least one arm (e.g., bilateral upper extremity lymphedema)
- Cardiac conditions including acute coronary syndrome within 3 months, symptomatic heart failure (NYHA class III/IV) within past 6 months, history of stroke, or cardiac transplantation
- Any other medical condition that would impair ability to participate or adhere to study interventions
- For CPET subgroup: absolute contraindications to exercise testing such as recent myocardial infarction, unstable angina, uncontrolled arrhythmias, severe aortic stenosis, recurrent syncope, active infections or serious pulmonary or cardiac conditions, mental impairment preventing cooperation
AI-Screening
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Trial Site Locations
Total: 7 locations
1
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
2
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)
Middletown, New Jersey, United States, 07748
Actively Recruiting
3
Memorial Sloan Kettering Bergen (Limited Protocol Activities)
Montvale, New Jersey, United States, 07645
Actively Recruiting
4
Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities)
Commack, New York, United States, 11725
Actively Recruiting
5
Memorial Sloan Kettering Westchester (Limited Protocol Activities)
Harrison, New York, United States, 10604
Actively Recruiting
6
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, New York, United States, 10065
Actively Recruiting
7
Memorial Sloan Kettering Nassau (Limited Protocol Activities)
Rockville Centre, New York, United States, 11553
Actively Recruiting
Research Team
A
Anthony Yu, MD
CONTACT
J
Jennifer Liu, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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