Actively Recruiting
Study of BLU-808 in Chronic Inducible Urticaria (CIndU) and Chronic Spontaneous Urticaria (CSU)
Led by Blueprint Medicines Corporation · Updated on 2026-02-17
105
Participants Needed
47
Research Sites
83 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a 2-part, proof-of-concept study to be conducted globally, designed to evaluate the safety, tolerability, clinical activity, pharmacokinetics, and pharmacodynamics of BLU-808, a wild type KIT inhibitor, in participants with CIndU (Part A) or CSU (Part B).
CONDITIONS
Official Title
Study of BLU-808 in Chronic Inducible Urticaria (CIndU) and Chronic Spontaneous Urticaria (CSU)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Part A: Confirmed diagnosis of Chronic Inducible Urticaria for 3 months or more prior to Day 1 that is inadequately controlled with second generation H1-antihistamines.
- Part B: Confirmed diagnosis of Chronic Spontaneous Urticaria for 3 months or more prior to Day 1 that is inadequately controlled with second generation H1-antihistamines.
You will not qualify if you...
- Part A: Any active urticaria that may interfere with study assessments.
- Part B: Participant has a clearly defined predominant cause of chronic urticaria or sole trigger such as symptomatic dermographism and cold-induced urticaria.
- Part A and Part B: Any other skin disease associated with chronic itching or angioedema that might influence the study evaluations and results, skin diseases associated with only wheals and no itch, or autoinflammatory diseases with urticarial lesions.
- Part A and Part B: Significant medical, psychiatric, or surgical conditions, or physical findings that may affect participant safety, study drug metabolism, study participation, or assessment of study results.
- Part A and Part B: Abnormal laboratory values that may pose risks or interfere with study participation.
- Part A and Part B: Pregnancy or plans for pregnancy; breastfeeding.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 47 locations
1
Allervie Clinical Research
Birmingham, Alabama, United States, 35209
Actively Recruiting
2
Acuro Research, Inc.
Little Rock, Arkansas, United States, 72205
Actively Recruiting
3
Modena Allergy & Asthma Clinical Research - La Jolla
La Jolla, California, United States, 92037
Actively Recruiting
4
Allergy & Asthma Associates of Southern California
Laguna Niguel, California, United States, 92677
Actively Recruiting
5
Allergy & Asthma Medical Group and Research Center
San Diego, California, United States, 92123
Actively Recruiting
6
Allergy Affiliates Inc.
Bradenton, Florida, United States, 34208
Actively Recruiting
7
University of South Florida
Tampa, Florida, United States, 33613
Actively Recruiting
8
Treasure Valley Medical Research
Boise, Idaho, United States, 83706
Actively Recruiting
9
Endeavor Health
Northbrook, Illinois, United States, 60062
Actively Recruiting
10
Dawes Fretzin Clinical Research Group, LLC
Indianapolis, Indiana, United States, 46250
Actively Recruiting
11
Southern Indiana Clinical Trials
New Albany, Indiana, United States, 47150
Actively Recruiting
12
The Indiana Clinical Trials Center
Plainfield, Indiana, United States, 46168
Actively Recruiting
13
Equity Medical - Bowling Green
Bowling Green, Kentucky, United States, 42104
Actively Recruiting
14
Johns Hopkins University
Baltimore, Maryland, United States, 21224
Actively Recruiting
15
Institute For Asthma & Allergy
Wheaton, Maryland, United States, 20902
Actively Recruiting
16
Chesapeake Clinical Research
White Marsh, Maryland, United States, 21236
Actively Recruiting
17
Henry Ford Health
Detroit, Michigan, United States, 48202
Actively Recruiting
18
Mayo Clinic
Rochester, Minnesota, United States, 55905
Actively Recruiting
19
The Clinical Research Center LLC.
St Louis, Missouri, United States, 63141
Actively Recruiting
20
Montana Medical Research, Inc.
Missoula, Montana, United States, 59808
Actively Recruiting
21
Equity Medical (at Cameron Dermatology) - New York
New York, New York, United States, 10023
Actively Recruiting
22
Bernstein Clinical Research Center
Cincinnati, Ohio, United States, 45236
Actively Recruiting
23
Allergy & Clinical Immunology Associates
Pittsburgh, Pennsylvania, United States, 15241
Actively Recruiting
24
National Allergy, Asthma & Urticaria Centers of Charleston
Charleston, South Carolina, United States, 29407
Actively Recruiting
25
Medical University of South Carolina (MUSC)
Charleston, South Carolina, United States, 29425
Actively Recruiting
26
Reveal Research Institute
Dallas, Texas, United States, 75235
Actively Recruiting
27
Austin Institute for Clinical Research
Pflugerville, Texas, United States, 78660
Actively Recruiting
28
Odense University Hospital - Odense
Odense, Denmark, 5000
Actively Recruiting
29
Fraunhofer-Institut fuer Translationale Medizin und Pharmakologie ITMP - Standort Berlin
Berlin, Germany, 12203
Actively Recruiting
30
Universitaetsklinikum Carl Gustav Carus Dresden
Dresden, Germany, 01307
Actively Recruiting
31
Universitaetsklinikum Frankfurt - Klinikum der Johann Wolfgang Goethe Universitaet
Frankfurt am Main, Germany, 60596
Actively Recruiting
32
Medizinische Hochschule Hannover (MHH)
Hanover, Germany, 30625
Actively Recruiting
33
Universitaetsmedizin der Johannes Gutenberg - Universitaet Mainz
Mainz, Germany, 55131
Actively Recruiting
34
Universitaetsklinikum Tuebingen
Tübingen, Germany, 72016
Actively Recruiting
35
Azienda Ospedale - Università Padova
Padova, Italy, 35128
Actively Recruiting
36
Azienda Ospedaliero Universitaria Policlinico Umberto
Rome, Italy, 00161
Actively Recruiting
37
Centro Ricerche Cliniche di Verona s.r.l.
Verona, Italy, 37134
Actively Recruiting
38
Hospital del Mar
Barcelona, Spain, 08003
Actively Recruiting
39
Hospital Universitario Vall d'Hebron
Barcelona, Spain, 08035
Actively Recruiting
40
Hospital Universitari de Bellvitge
Barcelona, Spain, 08907
Actively Recruiting
41
Hospital Regional Universitario de Malaga
Málaga, Spain, 29010
Actively Recruiting
42
National Taiwan University Hospital Hsin-Chu Branch
Hsinchu, Taiwan, 300
Actively Recruiting
43
Kaohsiung Veterans General Hospital (KSVGH)
Kaohsiung City, Taiwan, 813414
Actively Recruiting
44
Taipei Medical University - Shuang Ho Hospital
New Taipei City, Taiwan, 235
Actively Recruiting
45
China Medical University Hospital
Taichung, Taiwan, 40402
Actively Recruiting
46
National Taiwan University Hospital
Taipei, Taiwan, 100225
Actively Recruiting
47
Linkou Chang Gung Memorial Hospital (CGMHLK)
Taoyuan City, Taiwan, 105406
Actively Recruiting
Research Team
B
Blueprint Medicines
CONTACT
B
Blueprint Medicines, EU Contact
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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