Breath Test Study for Small Intestinal Bacterial Overgrowth in Adults with Gastroesophageal Reflux Disease After Proton Pump Inhibitor Treatment

What this Trial Is About

Researchers are evaluating how often small intestinal bacterial overgrowth SIBO happens after people with gastroesophageal reflux disease GERD take proton pump inhibitors PPIs. The study focuses on patients who have symptoms like heartburn and regurgitation and aims to better understand the relationship between PPI use and SIBO occurrence. This is an interventional study conducted by the Mayo Clinic. Participants with GERD symptoms who have been treated with a short course of PPIs will undergo breath testing to check for SIBO. During the breath test, participants drink a small carbohydrate solution and provide breath samples every 15 minutes for one hour, then every 30 minutes for the next two hours. This testing occurs approximately 8 weeks after PPI therapy to measure SIBO incidence and symptoms. Throughout the study, researchers will assess the presence of SIBO and related symptoms both before and after PPI treatment. Breath testing schedules and symptom evaluations will help determine changes associated with PPI use. The main outcome is the rate of SIBO after PPI therapy, with additional measures of symptoms and SIBO status at baseline. The study does not specify a maximum age and will enroll adults 18 years and older. Participants will be monitored until about 8 weeks after treatment.

A Study of Breath Testing for Small Intestinal Bacterial Overgrowth