Actively Recruiting

Phase 3
Age: 18Years +
All Genders
NCT06345729

A Study of Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004/KANDLELIT-004)

Led by Merck Sharp & Dohme LLC · Updated on 2026-05-11

600

Participants Needed

219

Research Sites

351 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This is a study evaluating the efficacy and safety of calderasib with pembrolizumab as first-line treatment in participants with locally advanced or metastatic non-small cell lung cancer (NSCLC) with identified Kirsten rat sarcoma viral oncogene homolog G12C (KRAS G12C) mutation and programmed cell death ligand 1 (PD-L1) tumor proportion score (TPS) ≥50%. There are two primary study hypotheses: Hypothesis 1: Combination of calderasib and pembrolizumab is superior to placebo plus pembrolizumab with respect to progression free survival (PFS) per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) by blinded independent central review (BICR). Hypothesis 2: Combination of calderasib plus pembrolizumab is superior to placebo plus pembrolizumab with respect to overall survival (OS).

CONDITIONS

Official Title

A Study of Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004/KANDLELIT-004)

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Histologically or cytologically confirmed diagnosis of non-small cell lung cancer (NSCLC)
  • Newly diagnosed Stage IIIB/IIIC NSCLC not eligible for curative resection or chemotherapy/radiation, or Stage IV (M1a, M1b, or M1c) by AJCC Version 8
  • Provides tumor tissue sample (archival within 5 years or new biopsy) for KRAS G12C mutation and PD-L1 testing
  • Recovery to less than Grade 1 or baseline from previous anticancer therapy adverse events
  • If HIV-infected, must have well-controlled HIV on antiretroviral therapy
  • If Hepatitis B surface antigen positive, must have received antiviral therapy for at least 4 weeks and have undetectable viral load
  • If history of Hepatitis C, must have undetectable viral load
Not Eligible

You will not qualify if you...

  • Diagnosis of small cell lung cancer or mixed tumors with small cell elements
  • Active inflammatory bowel disease requiring immunosuppressive medication or past history of inflammatory bowel disease
  • Known history or active neurologic paraneoplastic syndrome
  • Active infection requiring systemic therapy (exceptions apply)
  • Uncontrolled significant cardiovascular or cerebrovascular disease
  • Certain ophthalmological conditions including glaucoma, central serous retinopathy, retinal vein or artery occlusion, or retinal degenerative disease
  • Prior systemic anticancer therapy for locally advanced or metastatic NSCLC
  • Radiation therapy to the lung exceeding 30 Gray within 6 months before study
  • Radiotherapy within 2 weeks before study without recovery from toxicities
  • Active central nervous system metastases or carcinomatous meningitis
  • Additional progressing malignancy or treatment for malignancy within past 3 years
  • Active autoimmune disease requiring systemic treatment in past 2 years
  • History or current pneumonitis/interstitial lung disease requiring steroids
  • HIV-infected with history of Kaposi's sarcoma or Multicentric Castleman's Disease
  • History of allogenic tissue or solid organ transplant
  • Not fully recovered from effects of major surgery

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 219 locations

1

CBCC Global Research, Inc. ( Site 0123)

Bakersfield, California, United States, 93309

Actively Recruiting

2

Beverly Hills Cancer Center ( Site 0116)

Beverly Hills, California, United States, 90211

Actively Recruiting

3

Stamford Hospital ( Site 0136)

Stamford, Connecticut, United States, 06902

Actively Recruiting

4

Mount Sinai Cancer Center ( Site 0137)

Miami Beach, Florida, United States, 33140

Completed

5

Orchard Healthcare Research Inc. ( Site 0115)

Skokie, Illinois, United States, 60077

Actively Recruiting

6

Truman Medical Center ( Site 0126)

Kansas City, Missouri, United States, 64108

Actively Recruiting

7

Cox Medical Center North ( Site 0133)

Springfield, Missouri, United States, 65807

Actively Recruiting

8

St. Vincent Frontier Cancer Center-Research ( Site 0105)

Billings, Montana, United States, 59102

Actively Recruiting

9

Atlantic Health System Morristown Medical Center ( Site 0121)

Morristown, New Jersey, United States, 07960

Actively Recruiting

10

New York Oncology Hematology, P.C. ( Site 0132)

Albany, New York, United States, 12206

Actively Recruiting

11

University of Cincinnati Medical Center-University of Cincinnati Cancer Center ( Site 0103)

Cincinnati, Ohio, United States, 45219

Actively Recruiting

12

Kettering Health Main Campus-Kettering Health Cancer Center ( Site 0106)

Kettering, Ohio, United States, 45429

Completed

13

Lancaster General Hospital - Ann B Barshinger Cancer Institute ( Site 0134)

Lancaster, Pennsylvania, United States, 17601

Actively Recruiting

14

Oncology Consultants P.A. ( Site 0113)

Houston, Texas, United States, 77030

Actively Recruiting

15

Circuit Clinical/SSM Health Dean Medical Group ( Site 0129)

Madison, Wisconsin, United States, 53715

Actively Recruiting

16

AUSTRAL MEDICAL CENTER ( Site 0302)

CABA, Buenos Aires, Argentina, C1019ABS

Completed

17

Centro Oncologico Korben ( Site 0304)

CABA, Buenos Aires, Argentina, C1426AGE

Actively Recruiting

18

Instituto de Investigaciones Clínicas Mar del Plata ( Site 0300)

Mar del Plata, Buenos Aires, Argentina, B7600FZO

Actively Recruiting

19

Fundacion Estudios Clinicos ( Site 0306)

Rosario, Santa Fe Province, Argentina, S2000DEJ

Actively Recruiting

20

Sanatorio Parque ( Site 0301)

Rosario, Santa Fe Province, Argentina, S2000DSV

Actively Recruiting

21

Chris O'Brien Lifehouse ( Site 3000)

Camperdown, New South Wales, Australia, 2050

Actively Recruiting

22

Frankston Hospital ( Site 3002)

Frankston, Victoria, Australia, 3199

Actively Recruiting

23

One Clinical Research ( Site 3001)

Nedlands, Western Australia, Australia, 6009

Actively Recruiting

24

Medizinische Universität Graz-Klinische Abteilung für Pulmonologie ( Site 2401)

Graz, Styria, Austria, 8036

Actively Recruiting

25

Klinik Floridsdorf-Abteilung für Innere Medizin und Pneumologie ( Site 2400)

Vienna, Austria, 1210

Actively Recruiting

26

Hospital Mario Penna ( Site 0436)

Belo Horizonte, Minas Gerais, Brazil, 30380-472

Actively Recruiting

27

Hospital de Câncer de Recife ( Site 0447)

Recife, Pernambuco, Brazil, 50040-000

Actively Recruiting

28

Oncoclínica Oncologistas Associados ( Site 0441)

Teresina, Piauí, Brazil, 64049-200

Actively Recruiting

29

Liga Norte Riograndense Contra o Câncer ( Site 0439)

Natal, Rio Grande do Norte, Brazil, 59062-000

Actively Recruiting

30

Hospital de Caridade de Ijuí ( Site 0438)

Ijuí, Rio Grande do Sul, Brazil, 98700 000

Actively Recruiting

31

Hospital de Clínicas de Passo Fundo ( Site 0442)

Passo Fundo, Rio Grande do Sul, Brazil, 99010-260

Actively Recruiting

32

Irmandade da Santa Casa de Misericórdia de Porto Alegre-Centro Multidisciplinar de Pesquisa Clínica ( Site 0435)

Porto Alegre, Rio Grande do Sul, Brazil, 90050-170

Actively Recruiting

33

Fundação Pio XII - Hospital de Câncer de Barretos-Unidade de Pesquisa Clínica ( Site 0437)

Barretos, São Paulo, Brazil, 14784-400

Actively Recruiting

34

Instituto Nacional de Câncer - INCA ( Site 0446)

Rio de Janeiro, Brazil, 20230-130

Actively Recruiting

35

Americas ( Site 0431)

Rio de Janeiro, Brazil, 22775-001

Actively Recruiting

36

MBAL Uni Hospital-Department of Medical Oncology ( Site 1000)

Panagyurishte, Pazardzhik, Bulgaria, 4500

Actively Recruiting

37

Multiprofile Hospital for Active Treatment SerdikaМЕD EOOD-Second Department of Medical Oncology ( Site 1002)

Sofia, Sofia (stolitsa), Bulgaria, 1632

Actively Recruiting

38

MHAT - Heart and Brain ( Site 1006)

Pleven, Bulgaria, 5804

Actively Recruiting

39

Medical Center Futuremeds ( Site 1007)

Plovdiv, Bulgaria, 4000

Actively Recruiting

40

CancerCare Manitoba ( Site 0210)

Winnipeg, Manitoba, Canada, R3E 0V9

Actively Recruiting

41

QEII Health Sciences Centre - Victoria General Site-Dept. of Medical Oncology ( Site 0208)

Halifax, Nova Scotia, Canada, B3H 2Y9

Actively Recruiting

42

Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0205)

Hamilton, Ontario, Canada, L8V 5C2

Actively Recruiting

43

Sunnybrook Research Institute ( Site 0206)

Toronto, Ontario, Canada, M4N 3M5

Actively Recruiting

44

St. Marys Hospital Center ( Site 0204)

Montreal, Quebec, Canada, H3T 1M5

Actively Recruiting

45

Centre integre universitaire de sante et de services sociaux de la Mauricie-et-du-centre-du-quebec ( Site 0207)

Trois-Rivières, Quebec, Canada, G8Z 3R9

Actively Recruiting

46

Clinica Universidad Catolica del Maule-Oncology ( Site 0500)

Talca, Maule Region, Chile, 3465584

Actively Recruiting

47

Orlandi Oncologia-Oncology ( Site 0503)

Santiago, Region M. de Santiago, Chile, 7500713

Actively Recruiting

48

FALP-UIDO ( Site 0501)

Santiago, Region M. de Santiago, Chile, 7500921

Actively Recruiting

49

Centro de Oncología de Precisión-Oncology ( Site 0502)

Santiago, Region M. de Santiago, Chile, 7560908

Actively Recruiting

50

Bradfordhill-Clinical Area ( Site 0504)

Santiago, Region M. de Santiago, Chile, 8420383

Actively Recruiting

51

Anhui Provincial Cancer Hospital ( Site 3136)

Hefei, Anhui, China, 230000

Actively Recruiting

52

Beijing Cancer hospital ( Site 3133)

Beijing, Beijing Municipality, China, 100142

Actively Recruiting

53

Beijing Cancer hospital ( Site 3134)

Beijing, Beijing Municipality, China, 100142

Actively Recruiting

54

Beijing Peking Union Medical College Hospital-pneumology department ( Site 3102)

Beijing, Beijing Municipality, China, 100730

Actively Recruiting

55

Beijing Chest Hospital,Capital Medical University ( Site 3104)

Beijing, Beijing Municipality, China, 101149

Actively Recruiting

56

Chongqing University Cancer Hospital ( Site 3119)

Chongqing, Chongqing Municipality, China, 400030

Actively Recruiting

57

Army Medical Center of People's Liberation Army ( Site 3142)

Chongqing, Chongqing Municipality, China, 400042

Actively Recruiting

58

Fujian Cancer Hospital ( Site 3127)

Fuzhou, Fujian, China, 350014

Actively Recruiting

59

The First Affiliated hospital of Xiamen University ( Site 3148)

Xiamen, Fujian, China, 361003

Actively Recruiting

60

The First Affiliated Hospital of Guangzhou Medical University ( Site 3108)

Guangzhou, Guangdong, China, 510160

Actively Recruiting

61

Southern Medical University Nanfang Hospital ( Site 3128)

Guangzhou, Guangdong, China, 510515

Actively Recruiting

62

Sun Yat-sen University Cancer Center ( Site 3137)

Guangzhou, Guangdong, China, 510555

Actively Recruiting

63

Harbin Medical University Cancer Hospital ( Site 3123)

Harbin, Heilongjiang, China, 150000

Actively Recruiting

64

JIAMUSI TUBERCULOSIS HOSPITAL(CANCER HOSPITAL) ( Site 3124)

Jiamusi, Heilongjiang, China, 154007

Actively Recruiting

65

Henan Cancer Hospital ( Site 3149)

Zhengzhou, Henan, China, 450008

Actively Recruiting

66

Tongji Hospital Tongji Medical,Science & Technology ( Site 3113)

Wuhan, Hubei, China, 430000

Actively Recruiting

67

Hubei Cancer Hospital ( Site 3126)

Wuhan, Hubei, China, 430079

Actively Recruiting

68

The Second Xiangya Hospital of Central South University ( Site 3130)

Changsha, Hunan, China, 410011

Actively Recruiting

69

Hunan Cancer Hospital ( Site 3141)

Changsha, Hunan, China, 410013

Actively Recruiting

70

Nanjing Gulou Hospital ( Site 3122)

Nanjing, Jiangsu, China, 210008

Actively Recruiting

71

Nanjing First Hospital ( Site 3154)

Nanjing, Jiangsu, China, 210012

Active, Not Recruiting

72

The First Affiliated Hospital of Soochow University ( Site 3146)

Suzhou, Jiangsu, China, 215006

Actively Recruiting

73

Affiliated Hospital of Jiangnan University(Wuxi Fourth People's Hospital ) ( Site 3155)

Wuxi, Jiangsu, China, 214122

Actively Recruiting

74

The Second Affiliated Hospital of Nanchang University ( Site 3139)

Nanchang, Jiangxi, China, 330000

Actively Recruiting

75

The First affiliated hospital of Nanchang University (Xianghu campus) ( Site 3138)

Nanchang, Jiangxi, China, 330209

Actively Recruiting

76

Jilin Province Tumor Hospital ( Site 3107)

Changchun, Jilin, China, 130000

Actively Recruiting

77

The First Affiliated Hospital of Xi'an Jiaotong University ( Site 3150)

Xi'an, Shaanxi, China, 710000

Actively Recruiting

78

Shandong Cancer Hospital ( Site 3116)

Jinan, Shandong, China, 250117

Actively Recruiting

79

LinYi Cancer Hospital ( Site 3111)

Linyi, Shandong, China, 276001

Actively Recruiting

80

Shanghai Chest Hospital ( Site 3100)

Shanghai, Shanghai Municipality, China, 200030

Actively Recruiting

81

Fudan University Shanghai Cancer Center ( Site 3144)

Shanghai, Shanghai Municipality, China, 200032

Actively Recruiting

82

Zhongshan Hospital,Fudan University ( Site 3143)

Shanghai, Shanghai Municipality, China, 200032

Actively Recruiting

83

Shanxi Cancer Hospital ( Site 3131)

Taiyuan, Shanxi, China, 030000

Actively Recruiting

84

The Second Affiliated Hospital of Air Force Medical University ( Site 3117)

Xian, Shanxi, China, 710038

Actively Recruiting

85

The Second Affiliated Hospital of Air Force Medical University ( Site 3152)

Xian, Shanxi, China, 710038

Actively Recruiting

86

West China Hospital, Sichuan University ( Site 3140)

Chengdu, Sichuan, China, 610000

Actively Recruiting

87

The Third People's Hospital of Chengdu (CDTPH) ( Site 3157)

Chengdu, Sichuan, China, 610031

Actively Recruiting

88

Sichuan Cancer hospital. ( Site 3109)

Chengdu, Sichuan, China, 610042

Actively Recruiting

89

The Second People's Hospital of Neijiang ( Site 3105)

Neijiang, Sichuan, China, 641000

Actively Recruiting

90

Xinjiang Medical University Cancer Hospital - Urumqi ( Site 3101)

Ürümqi, Xinjiang, China, 830000

Actively Recruiting

91

Yunnan Province Cancer Hospital ( Site 3153)

Kunming, Yunnan, China, 650107

Actively Recruiting

92

The first Affiliated Hospital, Zhejiang University School of Medicine ( Site 3115)

Hangzhou, Zhejiang, China, 310006

Actively Recruiting

93

Sir Run Run Shaw Hospital of Zhejiang University School of Medicine ( Site 3121)

Hangzhou, Zhejiang, China, 310016

Actively Recruiting

94

Taizhou Hospital of Zhejiang Province ( Site 3145)

Linhai, Zhejiang, China, 317000

Actively Recruiting

95

The First Affiliated Hospital of Wenzhou Medical University ( Site 3151)

Wenzhou, Zhejiang, China, 325015

Actively Recruiting

96

Centre Hospitalier Universitaire Dijon Bourgogne - Hôpital François Mitterrand ( Site 1103)

Dijon, Bourgogne-Franche-Comté, France, 21000

Actively Recruiting

97

Centre Hospitalier Universitaire de Nîmes - Institut de Cancérologie du Gard - Hôpital Universitaire ( Site 1106)

Nîmes, Gard, France, 30029

Actively Recruiting

98

Clinique Teissier Groupe ( Site 1100)

Valenciennes, Nord, France, 59304

Actively Recruiting

99

Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne-ONCOLOGY ( Site 1101)

Clermont-Ferrand, Puy-de-Dome, France, 63003

Actively Recruiting

100

Centre Hospitalier d'Avignon-Service d'Oncologie médicale et d'hématologie clinique ( Site 1104)

Avignon, Vaucluse, France, 84000

Actively Recruiting

101

Hôpital Ambroise Paré-Department of Respiratory Diseases and Thoracic Oncology ( Site 1105)

Boulogne-Billancourt, Île-de-France Region, France, 92100

Actively Recruiting

102

High Technology Hospital Medcenter ( Site 1203)

Batumi, Adjara, Georgia, 6000

Actively Recruiting

103

Caucasus Medical Centre ( Site 1202)

Tbilisi, Adjara, Georgia, 0186

Actively Recruiting

104

American Hospital Network LLC ( Site 1208)

Tbilisi, Georgia, 0102

Actively Recruiting

105

Todua Clinic, LLC ( Site 1204)

Tbilisi, Georgia, 0112

Actively Recruiting

106

TSMU and Ingorokva High Medical Technology University Clinic LTD ( Site 1201)

Tbilisi, Georgia, 0144

Completed

107

New Hospitals ( Site 1200)

Tbilisi, Georgia, 0162

Actively Recruiting

108

Cancer Research Centre. Mardaleishvili Medical Centre ( Site 1205)

Tbilisi, Georgia, 0177

Actively Recruiting

109

Tbilisi Institute of Medicine ( Site 1206)

Tbilisi, Georgia, 1206

Completed

110

Marienhospital Stuttgart ( Site 1302)

Stuttgart, Baden-Wurttemberg, Germany, 70199

Actively Recruiting

111

Evangelisches Krankenhaus Bielefeld - Johannesstift ( Site 1307)

Bielefeld, North Rhine-Westphalia, Germany, 33611

Actively Recruiting

112

Krankenhaus Bethanien ( Site 1303)

Solingen, North Rhine-Westphalia, Germany, 42699

Actively Recruiting

113

UNIVERSITY HOSPITAL OF PATRAS-DIVISION OF ONCOLOGY ( Site 1402)

Pátrai, Achaia, Greece, 26504

Actively Recruiting

114

THORACIC GENERAL HOSPITAL OF ATHENS "I SOTIRIA"-3rd Dept of Internal Medicine and Laboratory, Oncol ( Site 1400)

Athens, Attica, Greece, 115 27

Actively Recruiting

115

Athens Medical Center ( Site 1406)

Marousi, Attica, Greece, 151 25

Actively Recruiting

116

University General Hospital of Larissa-Oncology Clinic ( Site 1403)

Larissa, Thessaly, Greece, 411 10

Actively Recruiting

117

Agios Loukas Clinic ( Site 1404)

Thessaloniki, Greece, 552 36

Actively Recruiting

118

G. Papanikolaou General Hospital-Pulmonary Clinic of Aristotle University of Thessaloniki ( Site 1405)

Thessaloniki, Greece, 570 10

Actively Recruiting

119

Sir H. N. Reliance Foundation Hospital and Research Centre ( Site 3201)

Mumbai, Maharashtra, India, 400004

Actively Recruiting

120

AIIMS New Delhi Dept of Medicine ( Site 3206)

New Delhi, National Capital Territory of Delhi, India, 110029

Actively Recruiting

121

Indraprastha Apollo Hospitals-APOLLO RESEARCH INNOVATION ( Site 3203)

New Delhi, National Capital Territory of Delhi, India, 110076

Actively Recruiting

122

Istituto Nazionale Tumori IRCCS Fondazione Pascale-Oncologia clinica sperimentale Toraco-Polmonare ( Site 1607)

Naples, Campania, Italy, 80131

Actively Recruiting

123

Ospedale Santa Maria delle Croci ( Site 1606)

Ravenna, Emilia-Romagna, Italy, 48121

Actively Recruiting

124

CRO-IRCCS-Clinical Oncology ( Site 1605)

Aviano, Friuli Venezia Giulia, Italy, 33081

Actively Recruiting

125

Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Medical Oncology ( Site 1601)

Rome, Lazio, Italy, 00168

Actively Recruiting

126

Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1600)

Milan, Lombardy, Italy, 20133

Actively Recruiting

127

Istituto Europeo di Oncologia IRCCS-Divisione di Oncologia Toracica ( Site 1604)

Milan, Lombardy, Italy, 20141

Actively Recruiting

128

A.O.R.N. Ospedale dei Colli - Monaldi V.-U.O.C Pneumologia Oncologica DH PNL ONC ( Site 1602)

Naples, Napoli, Italy, 80131

Actively Recruiting

129

Istituto Nazionale Tumori Regina Elena-Oncologia Medica 2 ( Site 1609)

Rome, Roma, Italy, 00144

Actively Recruiting

130

Azienda USL Toscana Nord Ovest_Ospedale Civile di Livorno-UOC Oncologia Medica Livorno ( Site 1608)

Livorno, Tuscany, Italy, 57124

Actively Recruiting

131

IOV - Istituto Oncologico Veneto IRCCS UOSD - Unità di ricerca clinica ( Site 1603)

Padova, Italy, 35131

Actively Recruiting

132

Nagoya University Hospital ( Site 3309)

Nagoya, Aichi-ken, Japan, 466-8560

Actively Recruiting

133

Fujita Health University Hospital ( Site 3310)

Toyoake, Aichi-ken, Japan, 470-1192

Actively Recruiting

134

National Cancer Center Hospital East ( Site 3303)

Kashiwa, Chiba, Japan, 277-8577

Actively Recruiting

135

National Hospital Organization Shikoku Cancer Center ( Site 3315)

Matsuyam, Ehime, Japan, 719-0280

Actively Recruiting

136

National Hospital Organization Kyushu Cancer Center ( Site 3316)

Fukuoka, Fukuoka, Japan, 811-1395

Actively Recruiting

137

Kurume University Hospital ( Site 3317)

Kurume, Fukuoka, Japan, 830-0011

Actively Recruiting

138

Gunma Prefectural Cancer Center ( Site 3302)

Ōta, Gunma, Japan, 373-8550

Actively Recruiting

139

Sapporo Medical University Hospital ( Site 3324)

Sapporo, Hokkaido, Japan, 060-8543

Actively Recruiting

140

Kanazawa University Hospital ( Site 3308)

Kanazawa, Ishikawa-ken, Japan, 920-8641

Actively Recruiting

141

St. Marianna University Hospital ( Site 3320)

Kawasaki, Kanagawa, Japan, 216-8511

Actively Recruiting

142

Saiseikai Matsusaka Municipal Hospital ( Site 3311)

Matsusaka, Mie-ken, Japan, 515-8544

Actively Recruiting

143

Miyagi Cancer Center ( Site 3301)

Natori-shi, Miyagi, Japan, 981-1293

Actively Recruiting

144

Sendai Kousei Hospital ( Site 3300)

Sendai, Miyagi, Japan, 981-0914

Actively Recruiting

145

Kansai Medical University Hospital ( Site 3312)

Hirakata, Osaka, Japan, 573-1191

Actively Recruiting

146

Osaka Medical and Pharmaceutical University Hospital ( Site 3313)

Takatsuki, Osaka, Japan, 569-8686

Actively Recruiting

147

Saitama Prefectural Cancer Center ( Site 3304)

Kitaadachi-gun, Saitama, Japan, 362-0806

Actively Recruiting

148

Nippon Medical School Hospital ( Site 3306)

Bunkyo, Tokyo, Japan, 113-8603

Actively Recruiting

149

Toho University Omori Medical Center ( Site 3319)

Ōta-ku, Tokyo, Japan, 143-8541

Actively Recruiting

150

Tokyo Medical University Hospital ( Site 3307)

Shinjuku, Tokyo, Japan, 160-0023

Actively Recruiting

151

National Center for Global Health and Medicine ( Site 3305)

Shinjuku, Tokyo, Japan, 162-8655

Actively Recruiting

152

Chiba University Hospital ( Site 3322)

Chiba, Japan, 260-8677

Actively Recruiting

153

Hiroshima City Hiroshima Citizens Hospital ( Site 3314)

Hiroshima, Japan, 730-8518

Actively Recruiting

154

Saiseikai Kumamoto Hospital ( Site 3318)

Kumamoto, Japan, 861-4193

Actively Recruiting

155

Niigata University Medical & Dental Hospital ( Site 3323)

Niigata, Japan, 951-8520

Actively Recruiting

156

Osaka Metropolitan University Hospital ( Site 3321)

Osaka, Japan, 545-8586

Actively Recruiting

157

Arké SMO S.A. de C.V. ( Site 0602)

Mexico City, Mexico City, Mexico, 06700

Actively Recruiting

158

Hospital Universitario "Dr. Jose Eleuterio Gonzalez"-Hematologia and Oncologia ( Site 0600)

Monterrey, Nuevo León, Mexico, 66460

Actively Recruiting

159

Oaxaca Site Management Organization S.C. ( Site 0603)

Oaxaca City, Mexico, 68000

Actively Recruiting

160

Ziekenhuis Gelderse Vallei ( Site 1705)

Ede, Gelderland, Netherlands, 6716 RP

Actively Recruiting

161

Ziekenhuis St. Jansdal-Poli Longziekten ( Site 1701)

Harderwijk, Gelderland, Netherlands, 3844 DG

Actively Recruiting

162

Isala, locatie Zwolle-Poli Longziekten ( Site 1700)

Zwolle, Overijssel, Netherlands, 8025 AB

Actively Recruiting

163

Universitair Medisch Centrum Utrecht ( Site 1704)

Utrecht, Netherlands, 3584 CX

Actively Recruiting

164

Auckland City Hospital ( Site 3400)

Auckland, New Zealand, 1023

Actively Recruiting

165

The Medical City ( Site 3507)

Pasig, National Capital Region, Philippines, 1600

Actively Recruiting

166

Lung Center of the Philippines-Pulmonary, Critical Care and Sleep Medicine ( Site 3503)

Quezon City, National Capital Region, Philippines, 1100

Actively Recruiting

167

Veterans Memorial Medical Center-Section of Oncology ( Site 3505)

Quezon City, National Capital Region, Philippines, 1100

Actively Recruiting

168

ST. LUKE'S MEDICAL CENTER-Medical oncology ( Site 3501)

Quezon City, National Capital Region, Philippines, 1102

Actively Recruiting

169

Szpital Specjalistyczny im. Henryka Klimontowicza ( Site 1801)

Gorlice, Lesser Poland Voivodeship, Poland, 38-300

Active, Not Recruiting

170

Pratia MCM Krakow ( Site 1808)

Krakow, Lesser Poland Voivodeship, Poland, 30-727

Actively Recruiting

171

Uniwersytecki Szpital Kliniczny nr 4 w Lublinie ( Site 1805)

Lublin, Lublin Voivodeship, Poland, 20-090

Actively Recruiting

172

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Pluca i Klatki Pier ( Site 1800)

Warsaw, Masovian Voivodeship, Poland, 02-781

Actively Recruiting

173

Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 1804)

Przemyśl, Podkarpackie Voivodeship, Poland, 37-700

Actively Recruiting

174

Centrul de Diagnostic si Tratament Provita. ( Site 1992)

Bucharest, Bucharest, Romania, 020335

Actively Recruiting

175

Centrul de Oncologie Sfantul Nectarie-Medical ( Site 1994)

Craiova, Dolj, Romania, 200542

Actively Recruiting

176

Cabinet Medical Oncomed ( Site 1998)

Timișoara, Timiș County, Romania, 300239

Actively Recruiting

177

SC ONCO CARD SRL ( Site 1995)

Brasov, Romania, 500052

Actively Recruiting

178

Institutul Oncologic Cluj-Oncologie Medicala ( Site 1999)

Cluj-Napoca, Romania, 400015

Actively Recruiting

179

Sigmedical Services SRL ( Site 1997)

Suceava, Romania, 720214

Actively Recruiting

180

The Catholic University of Korea, Incheon St. Mary's Hospital ( Site 3606)

Bupyeong-gu, Incheon, South Korea, 21431

Actively Recruiting

181

Chonnam National University Hwasun Hospital-Pulmonology ( Site 3604)

Hwasun, Jeonranamdo, South Korea, 58128

Completed

182

The Catholic University Of Korea St. Vincent's Hospital-Medical Oncology ( Site 3600)

Suwon, Kyonggi-do, South Korea, 16247

Actively Recruiting

183

Pusan National University Yangsan Hospital-Lung Cancer Clinic ( Site 3603)

Yangsan, Kyongsangnam-do, South Korea, 50612

Actively Recruiting

184

Yeungnam University Hospital ( Site 3607)

Daegu, Taegu-Kwangyokshi, South Korea, 42415

Actively Recruiting

185

Keimyung University Dongsan Hospital ( Site 3611)

Daegu, Taegu-Kwangyokshi, South Korea, 42601

Actively Recruiting

186

Chungnam national university hospital ( Site 3602)

Junggu, Taejon-Kwangyokshi, South Korea, 35015

Actively Recruiting

187

Inha University Hospital ( Site 3610)

Incheon, South Korea, 22332

Actively Recruiting

188

Kyung Hee University Hospital ( Site 3605)

Seoul, South Korea, 02447

Actively Recruiting

189

The Catholic University of Korea, Eunpyeong St. Mary's Hospital ( Site 3608)

Seoul, South Korea, 03312

Actively Recruiting

190

Korea University Guro Hospital ( Site 3601)

Seoul, South Korea, 08308

Actively Recruiting

191

Hospital Universitario Virgen de la Victoria ( Site 2021)

Málaga, Andalusia, Spain, 29010

Actively Recruiting

192

Hospital Insular de Gran Canaria-Oncology ( Site 2019)

Las Palmas de Gran Canaria, Las Palmas, Spain, 35001

Actively Recruiting

193

HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑON-ONCOLOGY ( Site 2012)

Madrid, Madrid, Comunidad de, Spain, 28009

Actively Recruiting

194

H.R.U Málaga - Hospital General-Oncology ( Site 2014)

Málaga, Malaga, Spain, 29011

Actively Recruiting

195

Hospital Universitari Vall d Hebron ( Site 2010)

Barcelona, Spain, 08035

Actively Recruiting

196

Hospital Universitario La Princesa ( Site 2020)

Madrid, Spain, 28006

Actively Recruiting

197

Hospital Universitario Fundación Jiménez Díaz-Oncology & Hematology ( Site 2017)

Madrid, Spain, 28040

Actively Recruiting

198

Hospital Universitario Virgen Macarena-Unidad de Investigación Oncológica ( Site 2015)

Seville, Spain, 41009

Actively Recruiting

199

Ege Universitesi Hastanesi-Chest Diseases Department ( Site 2102)

Bornova, İzmir, Turkey (Türkiye), 35100

Actively Recruiting

200

Adana Medical Park Seyhan Hastanesi-Medikal Onkoloji ( Site 2107)

Adana, Turkey (Türkiye), 01140

Actively Recruiting

201

SBU GULHANE EGITIM VE ARASTIRMA HASTANESI Onkoloji ( Site 2104)

Ankara, Turkey (Türkiye), 06010

Actively Recruiting

202

Hacettepe Universite Hastaneleri-oncology hospital ( Site 2101)

Ankara, Turkey (Türkiye), 06230

Actively Recruiting

203

Memorial Ankara Hastanesi-Medical Oncology ( Site 2106)

Ankara, Turkey (Türkiye), 06520

Actively Recruiting

204

Ankara Bilkent Şehir Hastanesi ( Site 2100)

Ankara, Turkey (Türkiye), 06800

Actively Recruiting

205

Medipol Mega Universite Hastanesi-oncology ( Site 2105)

Istanbul, Turkey (Türkiye), 34214

Actively Recruiting

206

TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 2103)

Istanbul, Turkey (Türkiye), 34722

Actively Recruiting

207

COMMUNAL NONPROFIT ENTERPRISE CLINICAL CENTER OF ONCOLOGY, HEMATOLOGY, TRANSPLANTOLOGY AND PALLIATI ( Site 2209)

Cherkasy, Cherkasy Oblast, Ukraine, 18009

Actively Recruiting

208

Regional Municipal Non-profit Enterprise "Bukovinian Clinica-structural unit of the clinical trials ( Site 2210)

Chernivtsi, Chernivetska Oblast, Ukraine, 58013

Actively Recruiting

209

Medical Center "Mriya Med-Service"-Clinical Research Department ( Site 2215)

Kryvyi Rih, Dnipropetrovsk Oblast, Ukraine, 50000

Actively Recruiting

210

Communal Non-Commercial Enterprise "Prykarpatski Clinical On-Surgery department #2 ( Site 2202)

Ivano-Frankivsk, Ivano-Frankivsk Oblast, Ukraine, 76018

Actively Recruiting

211

Kirovohrad Regional Oncology Center-Chemotherapy department ( Site 2204)

Kropyvnytskyi, Kirovohrad Oblast, Ukraine, 25011

Actively Recruiting

212

Medical Center "MedOffice Group" ( Site 2219)

Kiev, Kyivska Oblast, Ukraine, 03022

Actively Recruiting

213

Lviv Territorial Medical Union Multidisciplinary Clinical Hospital ( Site 2217)

Lviv, Lviv Oblast, Ukraine, 79059

Actively Recruiting

214

Rivne Regional Clinical Hospital ( Site 2205)

Rivne, Rivne Oblast, Ukraine, 33007

Completed

215

ME RIVNE REGIONAL ANTITUMOR CENTER ( Site 2920)

Rivne, Rivne Oblast, Ukraine, 33010

Actively Recruiting

216

Communal Noncommercial Enterprise "Podillia Regional Oncolog-Cardiothoracic department ( Site 2211)

Vinnytsia, Vinnytsia Oblast, Ukraine, 21029

Actively Recruiting

217

ME Volyn Regional Clinical Hospital of the Volyn Regional Council ( Site 2216)

Lutsk, Volyn Oblast, Ukraine, 43018

Actively Recruiting

218

Milton Keynes Hospital ( Site 2304)

Milton Keynes, Buckinghamshire, United Kingdom, MK6 5LD

Actively Recruiting

219

Royal Devon & Exeter Hospital-Oncology ( Site 2302)

Exeter, Devon, United Kingdom, EX2 5DW

Actively Recruiting

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Research Team

T

Toll Free Number

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

TRIPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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