Actively Recruiting
A Study of Cannabidiol in Young Adult Cannabis Users
Led by University of Colorado, Denver · Updated on 2026-05-01
200
Participants Needed
1
Research Sites
185 weeks
Total Duration
On this page
Sponsors
U
University of Colorado, Denver
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The investigators will study the harm-reducing effect of hemp-derived CBD in non-treatment-seeking emerging adults who use cannabis regularly. The study will use a novel naturalistic cannabis administration approach, which examines ecologically valid cannabis use utilizing a mobile lab setting to assess the effects of the cannabis products the participants regularly use. The investigators will recruit a sample of emerging adults, half of whom primarily use flower products and half of whom primarily use concentrate products. Individuals will be randomly assigned to hemp-derived CBD or placebo.
CONDITIONS
Official Title
A Study of Cannabidiol in Young Adult Cannabis Users
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ages 18 to 25 years
- Use cannabis flower or concentrates at least five days per week for the past year
- Not currently seeking to reduce or stop cannabis use
- Have at least two symptoms of cannabis use disorder according to DSM-5
You will not qualify if you...
- Use of any illegal substances other than alcohol, nicotine, or cannabis in the past 60 days
- Alcohol use on 3 or more days per week or more than 3 drinks per drinking day in the past 60 days
- Daily use of nicotine
- Diagnosis of psychotic disorder, bipolar disorder, major depression with suicidal ideation, or history of treatment for these
- Current cardiovascular or respiratory diseases
- Use of psychotropic or hepatotoxic medications
- Use of anti-epileptic drugs or medications interacting with Epidiolex, or history of seizures
- Use of strong or moderate CYP3A4 or CYP2C19 inhibitors or inducers
- Current or past liver disease or abnormal liver function tests
- For females, pregnancy, lactation, or not using approved birth control if of childbearing potential
- Current suicidality risk determined by clinical assessment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States, 80045
Actively Recruiting
Research Team
C
Christian J Hopfer, MD
CONTACT
K
Kristen M Raymond, BA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here