Actively Recruiting
A Study of CD371-YSNVZIL-18 CAR T Cells in People With Acute Myeloid Leukemia
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-02-19
15
Participants Needed
7
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to find out whether CD371-YSNVZ-IL18 CAR T cells are safe, and to look for the highest dose of CD371-YSNVZ-IL18 CAR T cells that cause few or mild side effects in participants.
CONDITIONS
Official Title
A Study of CD371-YSNVZIL-18 CAR T Cells in People With Acute Myeloid Leukemia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- History of CD371-positive acute myeloid leukemia (AML)
- Age 1 year or older and weight at least 10 kg for cell collection; no age/weight limit for adults
- Patients with prior allogeneic hematopoietic stem cell transplant (allo-HCT) eligible if at least 100 days post-transplant, no active graft-versus-host disease (GVHD), and off immunosuppressive agents for 30 days prior to collection or treatment
- Relapsed or refractory CD371-positive AML meeting disease-specific criteria for primary refractory, early or late first relapse, or advanced disease
- Adequate performance status: ECOG 0-1 or Karnosfsky 60 or higher for patients 16 years and older; Lansky 60 or higher if under 16 years
- Identification of suitable donor/source for allo-HCT as determined by treating physician
- Adequate organ function including liver, kidney, heart, and lung as defined in study criteria
You will not qualify if you...
- Pregnant or lactating women; women of childbearing potential not using effective contraception during and for 12 months after treatment
- Sexually active males not willing to use condoms during and for 12 months after treatment
- Radiographically detected or symptomatic central nervous system (CNS) disease, except adequately treated CNS leukemia
- Uncontrolled symptomatic illness including infection or psychiatric illness that would limit study compliance or pose unacceptable risk
- Impaired cardiac function with left ventricular ejection fraction below 50% or severe heart conditions such as NYHA class III/IV heart failure, recent myocardial infarction, or significant arrhythmia
- Positive HIV test
- Acute or chronic hepatitis B or C infection
- Use of bridging chemotherapy less than 1 week before lymphodepleting chemotherapy, except certain exceptions
- Isolated extramedullary disease
- Lack of suitable donor/source for allogeneic HSCT
- Active second malignancy requiring systemic treatment, except curatively treated malignancy without disease for over 2 years
- Unable to give informed consent
- Any other condition deemed by the investigator to make participation unsafe or unfeasible
AI-Screening
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Trial Site Locations
Total: 7 locations
1
Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
2
Memorial Sloan Kettering Monmouth (Limited protocol activities)
Middletown, New Jersey, United States, 07748
Actively Recruiting
3
Memorial Sloan Kettering Bergen (Limited Protocol Activities)
Montvale, New Jersey, United States, 07645
Actively Recruiting
4
Memorial Sloan Kettering Cancer Center @ Suffolk-Commack (Limited protocol activities)
Commack, New York, United States, 11725
Actively Recruiting
5
Memorial Sloan Kettering Westchester (Limited Protocol Activities)
Harrison, New York, United States, 10604
Actively Recruiting
6
Memorial Sloan Kettering Cancer Center (All protocol activites)
New York, New York, United States, 10065
Actively Recruiting
7
Memorial Sloan Kettering Nassau (Limited Protocol Activites)
Rockville Centre, New York, United States, 11553
Actively Recruiting
Research Team
M
Mark Geyer, MD
CONTACT
J
Jae Park, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
3
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