Actively Recruiting
A Study of CDX-622 in Participants With Mild to Moderate Asthma
Led by Celldex Therapeutics · Updated on 2026-04-01
12
Participants Needed
2
Research Sites
56 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a study to determine the safety, pharmacodynamics (PD), and pharmacokinetics (PK) of CDX-622 in adults with mild to moderate asthma.
CONDITIONS
Official Title
A Study of CDX-622 in Participants With Mild to Moderate Asthma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males and females, 18 years of age or older
- Diagnosis of mild to moderate asthma for at least 12 months
- Pre-bronchodilator forced expiratory volume in 1 second (FEV1) at least 70% of predicted normal
- Airway reversibility of at least 12% and 200 mL improvement in FEV1
- Both males and females of child-bearing potential must agree to use contraception during the study and for 150 days after treatment
- Willing and able to comply with all study requirements and procedures
You will not qualify if you...
- Females who are pregnant or nursing
- Pulmonary disease other than asthma
- Systemic diseases with elevated eosinophils other than asthma
- Hospitalization or use of oral corticosteroids due to asthma within the past 6 months
- History of needing ventilator support due to asthma
- Current nasal polyps
- Severe or uncontrolled asthma
- History of smoking or vaping within the past 12 months
- Tuberculosis, hepatitis B or C virus, or HIV infection
- Use of immunomodulating biologic therapies within the past 3 months
- Prior treatment with TSLP or KIT inhibitors such as tezepelumab or briquilimab
- Additional protocol defined inclusion and exclusion criteria may apply
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
The University of Kansas Medical Center
Kansas City, Kansas, United States, 66160
Actively Recruiting
2
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
Research Team
C
Celldex Therapeutics
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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