Actively Recruiting
A Study on the Changes of Glucose Metabolism and Exocrine Function in Patients With Chronic Pancreatitis
Led by Shanghai Changzheng Hospital · Updated on 2026-01-02
80
Participants Needed
2
Research Sites
560 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to investigate the impact of pancreatic exocrine insufficiency on the glucose profile and pancreatic and gastrointestinal endocrine hormones in patients with chronic pancreatitis through pancreatic enzyme intervention in a reverse manner. The primary objective is to observe the changes in glucose profile following pancreatic enzyme intervention in patients with chronic pancreatitis complicated by exocrine insufficiency and normal glucose metabolism. The secondary objective is to observe the changes in pancreatic endocrine and exocrine functions and gastrointestinal endocrine hormone levels following pancreatic enzyme intervention in patients with chronic pancreatitis complicated by exocrine insufficiency and normal glucose metabolism.
CONDITIONS
Official Title
A Study on the Changes of Glucose Metabolism and Exocrine Function in Patients With Chronic Pancreatitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female Chinese subjects aged 18 years or older
- Clear diagnosis of chronic pancreatitis
- Glycated hemoglobin (HbA1c) levels between 4% and 6%
- Fecal elastase-1 (FE-1) less than 100 µg/g
You will not qualify if you...
- History of diabetes or prediabetes, or HbA1c equal to or above 6.0%, or fasting venous glucose equal to or above 6.1 mmol/L
- Positive for islet-related antibodies
- Currently receiving or previously received pancreatic enzyme replacement therapy
- Allergy to components of pancreatic enzyme replacement therapy drugs
- Exocrine pancreatic insufficiency caused by other reasons such as post-gastrectomy or post-intestinal resection
- Undergoing pancreatic surgery other than endoscopic retrograde cholangiopancreatography (ERCP)
- Renal disease at stage G3, G4, or G5
- Decompensated chronic liver disease
- Receiving glucocorticoid therapy
- Pregnant or breastfeeding women
- Patients with malignant tumors
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Shanghai Changzheng Hospital
Shanghai, Shanghai Municipality, China, 200003
Actively Recruiting
2
Changzheng Hospital
Shanghai, China, 200003
Not Yet Recruiting
Research Team
T
Tuo Li, Doctor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
1
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