Actively Recruiting
Changes in Loading Conditions on Induction of General Anesthesia: Mechanisms of Post-Induction Hypotension (PIH)
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-01-30
250
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to understand how heart function and blood flow change in people receiving general anesthesia during surgery. The focus is on those who experience low blood pressure, known as post-induction hypotension, shortly after anesthesia is given. The study is observational and seeks to clarify how anesthesia affects heart pumping and circulation. Participants will receive standard anesthesia and perioperative care while researchers perform additional monitoring using echocardiography and Clearsight blood pressure measurements. These measurements happen before anesthesia, immediately after induction, and following intubation, continuing for 20 minutes to track changes in heart function and blood pressure. During the study, participants will undergo routine care with extra heart and blood flow assessments. Researchers will measure the proportion of patients experiencing low blood pressure within 20 minutes after anesthesia starts. The study involves monitoring vital signs and heart function with specialized equipment to gather detailed data on cardiovascular changes during surgery.
CONDITIONS
Brief Title
A Study of Changes in Heart Function and Blood Flow in People Receiving Anesthesia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients 18 years of age or older requiring general anesthesia for surgery
- Intubation required for anesthetic management and surgery
- Anticipated preparation time before incision of 20 minutes
- Baseline mean arterial pressure greater than 70 mmHg
You will not qualify if you...
- History of coronary artery disease
- History of cardiac disease such as hypertension, arrhythmias, valvular or structural abnormalities
- History of peripheral artery occlusive disease
- Current use of beta-blockers
- Current use of anti-hypertensive medications
- Patients receiving epidural, spinal, paravertebral, or serratus blocks before surgery
- Patients requiring rapid sequence induction with concurrent intubation
- Emergency surgery cases
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 20 minutes on the day of surgery
Participants undergo echocardiography and blood pressure measurements before, immediately after anesthesia induction, and after intubation.
1 visit during surgery
Duration - Up to 20 minutes after anesthesia induction
Participants are observed for changes in heart function and blood flow following anesthesia induction.
Continuous monitoring during the diagnostic evaluation visit
Trial Site Locations
Total: 1 location
1
Memorial Sloan Kettering Cancer Center (All protocol activites)
New York, New York, United States, 10065
Actively Recruiting
Research Team
A
Anahita Dabo-Trubelja, MD
G
Gregory Fischer, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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