Actively Recruiting
A Study of Changes in Ki67 Expression in People With Breast Cancer Receiving Endocrine Therapy Before Surgery
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-05-05
42
Participants Needed
1
Research Sites
260 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The researchers are doing this study to look at changes in Ki67 expression after at least 2 weeks of endocrine therapy in people with ER+/HER2- breast cancer undergoing cancer removal surgery. Participants will receive the endocrine therapy before their surgery. The researchers will look at how changes in Ki67 expression compare between participants who are carriers of the BRCA2 mutation and participants who are noncarriers of the BRCA2 mutation.
CONDITIONS
Official Title
A Study of Changes in Ki67 Expression in People With Breast Cancer Receiving Endocrine Therapy Before Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Postmenopausal women aged 6518 years with biopsy-proven stage I-III invasive breast cancer that is ER+/HER2-
- Scheduled to undergo upfront surgery
- Eligible for genetic testing in accordance with National Comprehensive Cancer Network guidelines (BRCA2 arm only)
You will not qualify if you...
- History of breast cancer
- Receipt of endocrine therapy for risk reduction in the previous 3 months
- Stage IV disease at presentation
- Scheduled to undergo neoadjuvant systemic chemotherapy
- Pregnant
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, New York, United States, 10065
Actively Recruiting
Research Team
M
Minna Lee, MD
CONTACT
K
Komal Jhaveri, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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