Actively Recruiting
The Effectiveness of a Natural Aqueous Extract of Chios Mastic in the Management of Dyspepsia: the MASTIQUA-D Randomized Controlled Clinical Trial
Led by Harokopio University · Updated on 2025-09-15
60
Participants Needed
1
Research Sites
34 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Dyspepsia includes a variety of upper digestive symptoms such as abdominal pain, bloating, nausea, and heartburn, affecting up to 40% of people worldwide and lowering quality of life. This study evaluates a natural product called Chios mastic water, which has antimicrobial, anti-inflammatory, and antioxidant properties. Researchers aim to see if a beverage enriched with this extract can improve dyspepsia symptoms and quality of life in adults. This is a 3-month randomized, double-blind controlled clinical trial involving adults aged 30 to 60 years with dyspepsia. Participants are randomly assigned to one of two groups: the intervention group receives 600 mL daily of a sparkling beverage enriched with 0.2% natural mastic aqueous extract, while the control group receives an identical placebo beverage without active ingredients. Both groups consume three 200 mL bottles daily for three months. Participants are asked to maintain their usual diet, physical activity, and medical treatments during the trial. The study team and participants are blinded to group assignments. At the start and end of the study, researchers assess body measurements, lifestyle habits, dyspepsia symptom severity, and quality of life. Blood samples are collected to measure biochemical markers like glucose metabolism, liver enzymes, and inflammatory markers. Researchers monitor side effects and may stop the intervention if needed. The primary outcome is the change in dyspepsia symptom severity after 12 weeks, along with changes in quality of life and inflammatory markers.
CONDITIONS
Brief Title
A Study of Chios Mastic Water in Dyspepsia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 30-60 years old
- Body mass index of 20-35 kg/m2
- Presence of dyspepsia
You will not qualify if you...
- Presence of chronic diseases such as diabetes mellitus, cancer, cardiovascular, hepatic, renal, respiratory, chronic inflammatory, or psychiatric diseases
- Presence of other chronic gastrointestinal diseases like gastroesophageal reflux, inflammatory bowel disease, or celiac disease
- Use of immunosuppressants, anti-inflammatories, antibiotics, or corticosteroids
- Use of dietary supplements or products containing Chios mastic
- Excessive alcohol consumption (over 210 g/week for men, over 140 g/week for women)
- Currently on a weight-loss diet or recent significant lifestyle changes within 6 months
- Pregnancy or breastfeeding (for women)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 3 months
Participants consume 600 mL daily of either a sparkling beverage enriched with natural mastic aqueous extract or a placebo beverage for 3 months, while maintaining their usual lifestyle and medical treatment.
Baseline visit and end-of-treatment visit
Trial Site Locations
Total: 1 location
1
Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University of Athens
Kallithea, Attica, Greece, 17676
Actively Recruiting
Research Team
G
Giannis Arnaoutis, PhD
M
Michael Georgoulis, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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