Actively Recruiting
Study of Circulating Monocytes in Patients With Ischemic Vascular Disease
Led by UConn Health · Updated on 2025-08-14
300
Participants Needed
1
Research Sites
730 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this research study is to discover the functions of circulating white blood cells, called monocytes, and associated circulating substances in heart attack and ischemic stroke patients. Ischemic Strokes (clots) occur as a result of an obstruction within a blood vessel supplying blood to the brain. A type of monocyte carrying a surface marker called "P2X4" helps the immune system sense and respond to danger signals from the body such as heart muscle and brain tissue injuries. The researchers expect to learn more about how these monocyte cells react to heart and brain tissue injury, and how the cells may then produce proteins or other chemical substances which promote the healing of heart muscle after heart attack and brain tissue after an ischemic stroke.
CONDITIONS
Official Title
Study of Circulating Monocytes in Patients With Ischemic Vascular Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men and women aged 18 years and over with symptoms, physical signs, and ECG changes characteristic of STEMI.
- Men and women aged 18 years and over with symptoms, physical signs, and ECG changes characteristic of NSTEMI.
- Men and women aged 18 years and older with stable coronary artery disease proven by prior MI history, angiography, or stress test but without unstable angina or acute coronary syndrome.
- Men and women aged 18 years and over with symptoms, physical signs, and CT/MRI changes characteristic of ischemic stroke.
- Men and women aged 18 years and over without heart failure, coronary disease, hypertension, diabetes, or other chronic diseases (healthy controls).
You will not qualify if you...
- Subjects unable to give informed consent (except ischemic stroke patients as per protocol).
- Pregnant subjects.
- Subjects with history of embolic, ischemic, or hemorrhagic stroke within the last 12 months.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Connecticut Health Center
Farmington, Connecticut, United States, 06030
Actively Recruiting
Research Team
F
Fahad Shah, BSc.
CONTACT
A
Adrianna G. Perez
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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