Actively Recruiting
A Study of Circulating Tumor DNA (ctDNA) Testing for People With B-Cell Lymphoma
Led by Memorial Sloan Kettering Cancer Center · Updated on 2025-12-18
50
Participants Needed
7
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to find out how many people with B-cell lymphoma who are at high risk for central nervous system/CNS relapse test positive for cerebral spinal fluid/CSF ctDNA but test negative for CNS involvement using standard tests. The study will also look at how often CNS relapse happens in people with and without detected CSF ctDNA.
CONDITIONS
Official Title
A Study of Circulating Tumor DNA (ctDNA) Testing for People With B-Cell Lymphoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed informed consent.
- Willingness and ability to follow the study requirements.
- Age 18 years or older.
- Diagnosis of one of the specified high-risk B-cell lymphoma subtypes according to 2016 WHO Classification with corresponding high CNS relapse risk criteria.
- Transformed DLBCL from indolent B-cell lymphoma allowed if no prior CNS involvement.
- Planned to receive standard chemoimmunotherapy.
- Able to safely undergo lumbar puncture without contraindications.
- No prior systemic therapy for aggressive B-cell lymphoma; prior treatment for indolent lymphoma permitted.
- ECOG performance status between 0 and 2.
You will not qualify if you...
- Receiving active systemic therapy for another malignancy within 2 years, except localized treatments with curative intent.
- Having an active concurrent malignancy except for certain localized skin, prostate, or in situ carcinomas.
- Uncontrolled illnesses that would prevent curative chemoimmunotherapy.
- Active infections at enrollment or major infection requiring IV antibiotics or hospitalization within 2 weeks before treatment.
- Psychiatric or social issues limiting ability to comply with study.
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Trial Site Locations
Total: 7 locations
1
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
2
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)
Middletown, New Jersey, United States, 07748
Actively Recruiting
3
Memorial Sloan Kettering Bergen (Limited Protocol Activities)
Montvale, New Jersey, United States, 07645
Actively Recruiting
4
Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities)
Commack, New York, United States, 11725
Actively Recruiting
5
Memorial Sloan Kettering Westchester (Limited Protocol Activities)
Harrison, New York, United States, 10604
Actively Recruiting
6
Memorial Sloan Kettering Cancer Center (All Protocol Activites)
New York, New York, United States, 10065
Actively Recruiting
7
Memorial Sloan Kettering Nassau (Limited Protocol Activities)
Rockville Centre, New York, United States, 11553
Actively Recruiting
Research Team
J
Jennifer Lue, MD
CONTACT
A
Ariela Noy, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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