Actively Recruiting
Study on the Clinical Application Value of PET Imaging Targeting GPC3 in Hepatocellular Carcinoma
Led by Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Updated on 2025-05-14
100
Participants Needed
1
Research Sites
113 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a diagnostic study. Patients were recruited from patients with clinically suspected or confirmed hepatocellular carcinoma and healthy volunteers were recruited for PET/or PET/CT imaging targeting a GPC3-specific probe (in the case of 68Ga-NOTA-aGPC3-scFv) , to observe the reaction of volunteers and patients after injection of drugs, to evaluate the pharmacokinetics in vivo and the efficacy of diagnosis and staging, and to perform PET CT imaging in patients with contraindications. General Information, clinical data, blood routine, liver and renal function, and other imaging data were collected. The final diagnosis was based on the histopathology of biopsy or surgical specimens.
CONDITIONS
Official Title
Study on the Clinical Application Value of PET Imaging Targeting GPC3 in Hepatocellular Carcinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Voluntarily participate and able to sign informed consent
- Adults aged 18 to 65 years, any gender
- Newly diagnosed or clinically suspected hepatocellular carcinoma with supporting imaging or histopathologic evidence
- Healthy volunteers
- Patients with a history of hepatocellular carcinoma, including remission or recurrence after treatment
- Willing and able to follow scheduled visits, treatment plans, and laboratory tests
You will not qualify if you...
- Pregnant or lactating patients
- Unable or unwilling to sign informed consent
- Acute systemic diseases or electrolyte disorders
- Known allergy to GPC3 imaging agents or their components
- Fasting blood glucose over 11.0 mmol/L before 18F-FDG injection
- Unable to complete PET/MR or PET/CT exams due to physical or psychological reasons
- Poor compliance or other factors unfavorable for study participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
China, Hubei Province
Wuhan, Hubei, China, 430022
Actively Recruiting
Research Team
X
Xiaoli Lan, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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