Actively Recruiting
A Study of Clinical Outcomes in Participants With EGFR Mutated Advanced Non-Small Cell Lung Cancer (NSCLC) in a Real-World Setting
Led by Janssen Research & Development, LLC · Updated on 2026-05-08
380
Participants Needed
60
Research Sites
262 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to describe the clinical and health-related outcomes of amivantamab-containing regimens for the treatment of common epidermal growth factor receptor (EGFR) mutated non-small cell lung cancer (NSCLC; most common type of lung cancer) in a real-world setting. Metastatic NSCLC is when this disease spreads to other parts of body. NSCLC may occur due to mutations (changes) in many genes including epidermal growth factor receptor (EGFR).
CONDITIONS
Official Title
A Study of Clinical Outcomes in Participants With EGFR Mutated Advanced Non-Small Cell Lung Cancer (NSCLC) in a Real-World Setting
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Confirmed diagnosis of common EGFR-mutated non-small cell lung cancer (NSCLC) with EGFR exon 19 deletions or exon 21 L858R substitution
- Eligible for an amivantamab-containing regimen as judged by the treating physician and according to approved indications and local product guidelines
- Signed informed consent allowing source data verification following local requirements
- Planned initiation of an amivantamab-containing regimen for the first time within 4 weeks after the start of data collection
- Decision to treat with an amivantamab-containing regimen made before enrollment and separate from study participation decision
You will not qualify if you...
- Receiving an active systemic anticancer treatment for advanced NSCLC not included in the locally approved combination with amivantamab at treatment start (except one cycle of platinum-based chemotherapy allowed before first amivantamab dose in first-line setting)
- Prior treatment with amivantamab in a clinical trial or compassionate use
- Receiving a biosimilar or non-original biologic agent instead of amivantamab
- Having conditions listed as contraindications for amivantamab or other essential agents in the amivantamab-containing regimen according to the local product guidelines
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 60 locations
1
University Hospital Graz
Graz, Austria, 8036
Actively Recruiting
2
Klinikum Klagenfurt am Worthersee
Klagenfurt, Austria, 9020
Actively Recruiting
3
UZ Brussel
Brussels, Belgium, 1090
Actively Recruiting
4
Az Groeninge
Kortrijk, Belgium, 8500
Actively Recruiting
5
Vitaz
Sint-Niklaas, Belgium, 9100
Actively Recruiting
6
Fakultni nemocnice Brno
Brno, Czechia, 625 00
Actively Recruiting
7
Fakultni nemocnice Hradec Kralove
Hradec Králové, Czechia, 500 05
Actively Recruiting
8
Fakultni nemocnice Olomouc
Olomouc, Czechia, 77900
Actively Recruiting
9
Fakultni Thomayerova nemocnice
Prague, Czechia, 140 59
Actively Recruiting
10
MVZ am Klinikum Aschaffenburg Onkologie
Aschaffenburg, Germany, 63739
Actively Recruiting
11
Evangelisches Klinikum Bethel
Bielefeld, Germany, 33611
Actively Recruiting
12
Augusta Kliniken Bochum Hattingen
Bochum, Germany, 44791
Actively Recruiting
13
Klinikum Chemnitz gGmbH
Chemnitz, Germany, 09113
Actively Recruiting
14
Haematologie u Onkologie Koeln MV Zentrum
Cologne, Germany, 50677
Actively Recruiting
15
Kliniken Essen-Mitte; Evangelische Huyssens-Stiftung
Essen, Germany, 45136
Actively Recruiting
16
Facharztzentrum Eppendorf
Hamburg, Germany, 20249
Actively Recruiting
17
Onkologie am Raschplatz
Hanover, Germany, 30161
Actively Recruiting
18
Klinikum Region Hannover Klinikum Siloah
Hanover, Germany, 30449
Actively Recruiting
19
Lungenklinik Hemer
Hemer, Germany, 58675
Actively Recruiting
20
Klinikum Konstanz
Konstanz, Germany, 78464
Actively Recruiting
21
MVZ fur Hamatologie und Onkologie Rhein Kreis GmbH
Neuss, Germany, 41462
Actively Recruiting
22
Knappschaft Kliniken MVZ Nord GmbH
Recklinghausen, Germany, 45659
Actively Recruiting
23
MVZ Onkologie Groschek Keller
Stolberg, Germany, 52222
Actively Recruiting
24
Bundeswehrkrankenhaus Ulm
Ulm, Germany, 89081
Actively Recruiting
25
Rabin Medical Center
Petah Tikva, Israel, 4941492
Actively Recruiting
26
Sheba Medical Center
Ramat Gan, Israel, 5262000
Actively Recruiting
27
Assuta MC
Tel Aviv, Israel, 6971028
Actively Recruiting
28
Ospedale San Giuseppe Moscati di Avellino
Avellino, Italy, 83100
Actively Recruiting
29
Oncologia Medica - Irccs - Istituto Tumori Giovanni Paolo II
Bari, Italy, 70124
Actively Recruiting
30
ASST Spedali Civili Brescia
Brescia, Italy, 25123
Actively Recruiting
31
Istituto di Candiolo, IRCCS
Candiolo, Italy, 10060
Actively Recruiting
32
PO G.Rodolico, AOU Policlinico-Vittorio Emanuele Catania
Catania, Italy, 95123
Actively Recruiting
33
Azienda Ospedaliera Pugliese Ciaccio Catanzaro
Catanzaro, Italy, 88100
Actively Recruiting
34
Ospedale Policlinico San Martino IRCCS
Genova, Italy, 16132
Actively Recruiting
35
Azienda Ospedaliera ''Vito Fazzi''
Lecce, Italy, 73100
Actively Recruiting
36
San Raffaele Hospital
Milan, Italy, 20132
Actively Recruiting
37
Istituto Dei Tumori Di Milano
Milan, Italy, 20133
Actively Recruiting
38
European Institute of Oncology
Milan, Italy, 20141
Actively Recruiting
39
ASST Grande Ospedale Metropolitano Niguarda
Milan, Italy, 20162
Actively Recruiting
40
Fondazione G Pascale Istituto Nazionale Tumori IRCCS
Naples, Italy, 80131
Actively Recruiting
41
Azienda Ospedaliero Universitaria Maggiore della Carita di Novara
Novara, Italy, 28100
Actively Recruiting
42
ASL Gallura - Ospedale Giovanni Paolo II
Olbia, Italy, 07026
Actively Recruiting
43
Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone
Palermo, Italy, 90127
Actively Recruiting
44
A.O.R Villa Sofia Cervello
Palermo, Italy, 90146
Actively Recruiting
45
Fondazione Policlinico Universitario A Gemelli IRCCS
Roma, Italy, 00168
Actively Recruiting
46
Campus Bio Medico di Roma
Roma, Italy, 128
Actively Recruiting
47
Azienda Ospedaliero Universitaria di Sassari
Sassari, Italy, 07100
Actively Recruiting
48
Ospedali Riuniti Di Ancona
Torrette-Ancona, Italy, 60126
Actively Recruiting
49
Hosp Reina Sofia
Córdoba, Spain, 14004
Actively Recruiting
50
Hosp. de Jerez de La Frontera
Jerez de la Frontera, Spain, 11407
Actively Recruiting
51
Hosp. Univ. Lucus Augusti
Lugo, Spain, 27003
Actively Recruiting
52
Complexo Hosp. Univ. de Ourense
Ourense, Spain, 32005
Actively Recruiting
53
Hospital Universitario Virgen Rocio
Seville, Spain, 41013
Actively Recruiting
54
Hosp. Clinico Univ. de Valladolid
Valladolid, Spain, 47003
Actively Recruiting
55
Royal United Hospital
Bath, United Kingdom, BA1 3NG
Actively Recruiting
56
Eastbourne District General Hospital
Eastbourne, United Kingdom, BN21 2UD
Actively Recruiting
57
New Cross Hospital
Heath Town, United Kingdom, WV10 0QP
Actively Recruiting
58
Royal Marsden Hospital
London, United Kingdom, SW3 6JJ
Actively Recruiting
59
The Christie NHS Foundation Trust Christie Hospital
Manchester, United Kingdom, M20 4BX
Actively Recruiting
60
Royal Marsden Hospital (Sutton)
Sutton, United Kingdom, SM2 5PT
Actively Recruiting
Research Team
S
Study Contact
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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