Actively Recruiting
Study of CM518D1 in Patients With Advanced Solid Tumors
Led by Keymed Biosciences Co.Ltd · Updated on 2025-11-17
434
Participants Needed
1
Research Sites
235 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is an interventional study to assess the safety, tolerability, efficacy, pharmacokinetics, and immunogenicity of CM518D1 in patients with advanced solid tumors.
CONDITIONS
Official Title
Study of CM518D1 in Patients With Advanced Solid Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female 18 to 75 years of age
- Histologically or cytologically confirmed advanced solid tumors
- At least one measurable lesion according to RECIST v1.1
- Expected survival time of at least 3 months as judged by the investigator
You will not qualify if you...
- Received any chemotherapy, monoclonal antibodies, targeted therapy, radioimmunoconjugates, ADCs, or investigational anti-tumor therapy within 28 days or 5 half-lives before first dose
- Major surgery within 28 days prior to first dose
- Radiotherapy within 21 days prior to first dose
- Systemic glucocorticoid therapy over 10 mg prednisone or equivalent daily, or other immunosuppressive therapy within 7 days prior to first dose
- Received any CDH17-targeted therapy
- History of other malignancies within 5 years prior to first dose, except cured basal/squamous cell skin carcinoma, carcinoma cervix in situ, or breast ductal carcinoma in situ
- Hypersensitivity to the investigational drug or its excipients
- Pregnant or lactating female patients
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Sun Yat-sen University Cancer Center (SYSUCC)
Guangzhou, Guangdong, China
Actively Recruiting
Research Team
Q
Qian Jia
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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