Actively Recruiting
A Study to Understand and Prevent Gastric Cancer by Examining Precancerous Stomach Conditions and Risk Factors
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-01-30
3200
Participants Needed
7
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are creating a registry to study people with early changes in the stomach lining that may lead to gastric cancer. This includes those with gastric atrophy, intestinal metaplasia, and dysplasia. The study also enrolls healthy individuals and people with gastric cancer to compare baseline characteristics and better understand risk factors for disease progression. Participants fall into three groups those with specific stomach lesions, healthy controls, and people with gastric cancer. The study collects information through questionnaires about clinical history, environmental exposures, lifestyle, and diet. This observational study does not involve any treatment but gathers health data to support future research. Participants will complete questionnaires and provide health information over a period that may last up to 10 years. The main goal is to build a detailed participant registry. Researchers will monitor and analyze the collected data to identify factors related to the progression of stomach lesions to cancer. Participation involves regular data collection but no active treatment, with safety and privacy monitored throughout the study.
CONDITIONS
Brief Title
A Study Collecting Health Information to Understand and Prevent Gastric Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Able to read and understand English or Spanish
- Diagnosed with gastric atrophy, intestinal metaplasia, or dysplasia confirmed by biopsy, or prior early gastric cancer treated endoscopically with no disease evidence
- Healthy individuals with no history of cancer or gastric lesions undergoing endoscopy
- Individuals with known early gastric adenocarcinoma undergoing surgery
You will not qualify if you...
- Under 18 years old
- Pregnant women (may join after delivery)
- History of upper gastrointestinal surgery or cancer with active treatment or diagnosis within 1 year, except for certain gastric cancers
- Severe other health conditions with life expectancy under 2 years or preventing elective endoscopy
- Hereditary Diffuse Gastric Cancer Syndrome or multiple genetic mutations
- High risk esophageal or duodenal lesions such as duodenal adenoma or esophageal/gastroesophageal junction dysplasia or cancer
- Risk factors increasing biopsy complications like clotting disorders
Research Team
M
Monika Laszkowska, MD
X
Xiang Shu, PhD
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