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A Study That Collects Participant Data and Biospecimens to Analyze Pathogenic Exosomes That Mediate Increased Vascular Dementia Risk in Individuals With Herpes Zoster.
Led by Center for Clinical Studies, Texas · Updated on 2025-12-11
375
Participants Needed
2
Research Sites
285 weeks
Total Duration
On this page
Sponsors
C
Center for Clinical Studies, Texas
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this observational research study is to study if patients with herpes zoster, also known as Shingles, have a higher risk of vascular dysfunction (problems with blood vessels, including stroke) and vascular dementia (problems with mental decline as a result of decreased blood flow to the brain) compared to patients without herpes zoster. Patients are evaluated based on the group they are assigned too: 1. Herpes Zoster (HZ) Group: individuals presenting with untreated herpes zoster. These participants will have 6 visits: * Day 1 = 1st day presenting to clinic with acute zoster * 7 days post zoster * 1 month after Day 1 * 3 months after Day 1 * 6 months after Day 1 * 12 months after Day 1 2. Control Group: individuals without herpes zoster o Day 1 (only 1 visit will be completed) This study does not have a study medication/device. Standard of care for all patients will be followed.
CONDITIONS
Official Title
A Study That Collects Participant Data and Biospecimens to Analyze Pathogenic Exosomes That Mediate Increased Vascular Dementia Risk in Individuals With Herpes Zoster.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 18 years or older
- Present to clinic for routine dermatologic evaluation with or without rash
- Willing and able to complete study visits and procedures
- Able to communicate effectively with study team
- Have adequate venous access and willing to undergo blood draws
- Able to provide written informed consent
- For herpes zoster group: Present with acute, untreated vesicle-stage herpes zoster
- Able and willing to attend follow-up visits at 7 days, 1 month, 3 months, 6 months, and 12 months after initial visit
You will not qualify if you...
- Pregnant or breastfeeding female individuals
- Currently receiving systemic or topical antivirals for varicella zoster virus
- Allergy or sensitivity to antiviral medications for herpes zoster
- History of herpes zoster diagnosis within the last 8 years
- Received herpes zoster vaccine within the last 8 years
- Received any vaccinations within the last 3 months
- Taking immunosuppressive therapies, including medications or radiation
- Taking any anticoagulant medications
- History of any blood clotting disorders
- History of end-stage kidney disease or uremia
- History of end-stage liver disease
- History of HIV infection
- Had COVID-19 infection in the last 3 months
- History of non-skin cancers within the last 3 months
- History of serious infection requiring hospitalization within the last 3 months
- History of stroke or heart attack within the last 12 months
- History of cerebrovascular accident within the last 12 months
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Center for Clinical Studies, LTD. LLP
Houston, Texas, United States, 77004
Actively Recruiting
2
Center for Clinical Studies, LTD. LLP
Webster, Texas, United States, 77598
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Research Team
S
Study Principal Investigator
CONTACT
D
Director of Research
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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