Pathogenic Exosomes During Herpes Zoster Mediate Increased Vascular Dementia Risk

What this Trial Is About

Researchers are investigating whether people with herpes zoster, also known as shingles, have a higher risk of blood vessel problems, including stroke, and vascular dementia compared to those without herpes zoster. The study focuses on understanding how exosomes, small particles in the blood, might contribute to these risks by promoting inflammation and clotting, which can affect brain blood flow. This observational research aims to clarify how herpes zoster could lead to vascular dementia and stroke over time. Participants are divided into two groups: those with untreated acute herpes zoster and those without herpes zoster. The herpes zoster group will have six visits over a year, starting from the first day of rash appearance and continuing at 7 days, 1 month, 3 months, 6 months, and 12 months after. The control group will have a single visit. No study medications or devices are given; all participants receive standard care. During the visits, the study collects data and blood samples to analyze exosome content and how it affects cells involved in blood vessel function. Researchers will measure proteins and genetic material in exosomes linked to vascular damage and monitor inflammatory responses. They will also assess platelet activation, blood vessel cell health, and the risk of stroke or vascular events. The primary goal is to understand the mechanisms behind increased vascular dementia risk in herpes zoster patients over a 12-month period.

A Study That Collects Participant Data and Biospecimens to Analyze Pathogenic Exosomes That Mediate Increased Vascular Dementia Risk in Individuals With Herpes Zoster.