Immunotherapy in B-Cell Acute Lymphoblastic Leukemia.
Kara L Davis, Catherine C Yao, Jessica A O Zimmerman...
https://pubmed.ncbi.nlm.nih.gov/41671463Actively Recruiting
Phase 2
Age: 1Year - 30Years
All Genders
ID04546399
A Phase 2 Study of Blinatumomab With or Without Nivolumab in Patients Aged 1 to Under 31 Years With First Relapse of B-Cell Acute Lymphoblastic Leukemia
Led by National Cancer Institute (NCI) · Updated on 2025-09-10
461
Participants Needed
215
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the combination of nivolumab and blinatumomab compared to blinatumomab alone in patients aged 1 to under 31 years with first relapse of CD19+ B-cell acute lymphoblastic leukemia (B-ALL), including those with Down syndrome. This phase II trial aims to compare event-free survival and remission rates, as well as assess safety and tolerability of these treatments in this patient group. Treatment involves several groups and arms with different combinations of drugs including dexamethasone, blinatumomab, nivolumab, methotrexate, and others. Some groups receive pre-immunotherapy treatments depending on disease characteristics. Treatment cycles last about 36 to 37 days and may repeat up to two cycles unless disease progression or unacceptable toxicity occurs. Radiation therapy and various chemotherapy regimens are also part of the treatment for certain patients. Participants undergo lumbar punctures, bone marrow biopsies and aspirations, and collections of blood, urine, and cerebrospinal fluid throughout the study. After treatment completion, they are followed up every 3 months for 1 year. The main results measured include minimal residual disease-negative remission rates and event-free survival. Safety, adverse events, and other clinical factors are closely monitored during and after treatment.
CONDITIONS
Brief Title
A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)
Who Can Participate
Age: 1Year - 30Years
All Genders
Eligibility Criteria
You may qualify if you...
- Patients aged 1 to under 31 years at enrollment
- First relapse of CD19 positive B-cell acute lymphoblastic leukemia in isolated bone marrow, isolated CNS/testicular relapse, or combined bone marrow with CNS/testicular relapse
- Patients with Down syndrome with isolated bone marrow or combined bone marrow with CNS/testicular relapse
- Performance status score of 0, 1, or 2 using ECOG, Karnofsky (over 16 years), or Lansky (16 years or younger) scales
- Fully recovered from prior chemotherapy, immunotherapy, or radiotherapy
- Prior blinatumomab or CD19 CAR therapy allowed if relapse blasts express CD19
- No prior hematopoietic stem cell transplant
- May have had up to five days of steroids or hydroxyurea before enrollment
- Adequate kidney function based on creatinine clearance or age/sex-specific serum creatinine
- Adequate heart function with shortening fraction ≥27% or ejection fraction ≥50%
- No dyspnea at rest and pulse oximetry >94% if clinically indicated
- Informed consent signed
- Compliance with all institutional, FDA, and NCI human study requirements
You will not qualify if you...
- Diagnosis of B-lymphoblastic lymphoma, Burkitt leukemia/lymphoma, mature B-cell leukemia, Philadelphia chromosome positive B-ALL, or mixed phenotype acute leukemia
- Known Charcot-Marie-Tooth disease
- Known MYC translocation associated with mature B-cell ALL
- Active uncontrolled infection including recent positive blood cultures, ongoing antibiotics with symptoms, fever with infection signs, recent fungal infection, or active viral/protozoal infections requiring IV treatment
- Known genetic syndromes affecting bone marrow (e.g., Bloom syndrome, Fanconi anemia)
- Uncontrolled HIV, hepatitis B or C infections unless well controlled and undetectable
- Significant CNS disorders preventing blinatumomab treatment, including severe neurologic or autoimmune disease involving CNS
- Active autoimmune disease except certain controlled conditions
- Non-hematopoietic, non-CNS/testicular extramedullary disease in Group 4 or Down syndrome patients
- Female patients of childbearing potential without negative pregnancy test or effective contraception
- Lactating females unwilling to stop breastfeeding during and after treatment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
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Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - Up to 2 cycles of 36 to 37 days each
Participants receive treatment with blinatumomab alone or blinatumomab combined with nivolumab. Treatment cycles last 36 to 37 days and include medications given by infusion, injection, or orally, and may involve lumbar puncture, bone marrow biopsy, and collection of blood, urine, and cerebrospinal fluid. Treatment repeats for up to 2 cycles in the absence of disease progression or unacceptable toxicity.
Multiple visits during each cycle with medication infusions and procedures
Follow-up
Duration - 1 year
After completing study treatment, participants are followed up every 3 months for 1 year to monitor health and any long-term effects.
Quarterly visits every 3 months
Trial Site Locations
Total: 215 locations
1
Children's Hospital of Alabama
Birmingham, Alabama, United States, 35233
Actively Recruiting
2
USA Health Strada Patient Care Center
Mobile, Alabama, United States, 36604
Actively Recruiting
3
Providence Alaska Medical Center
Anchorage, Alaska, United States, 99508
Suspended
4
Kingman Regional Medical Center
Kingman, Arizona, United States, 86401
Suspended
5
Banner Children's at Desert
Mesa, Arizona, United States, 85202
Actively Recruiting
6
Phoenix Childrens Hospital
Phoenix, Arizona, United States, 85016
Actively Recruiting
7
Banner University Medical Center - Tucson
Tucson, Arizona, United States, 85719
Actively Recruiting
8
Arkansas Children's Hospital
Little Rock, Arkansas, United States, 72202-3591
Actively Recruiting
9
Kaiser Permanente-Anaheim
Anaheim, California, United States, 92806
Actively Recruiting
10
PCR Oncology
Arroyo Grande, California, United States, 93420
Suspended
11
Kaiser Permanente-Bellflower
Bellflower, California, United States, 90706
Suspended
12
Kaiser Permanente Downey Medical Center
Downey, California, United States, 90242
Actively Recruiting
13
City of Hope Comprehensive Cancer Center
Duarte, California, United States, 91010
Active, Not Recruiting
14
Kaiser Permanente-Fontana
Fontana, California, United States, 92335
Actively Recruiting
15
Loma Linda University Medical Center
Loma Linda, California, United States, 92354
Actively Recruiting
16
Children's Hospital Los Angeles
Los Angeles, California, United States, 90027
Actively Recruiting
17
Kaiser Permanente Los Angeles Medical Center
Los Angeles, California, United States, 90027
Suspended
18
Cedars Sinai Medical Center
Los Angeles, California, United States, 90048
Actively Recruiting
19
Mattel Children's Hospital UCLA
Los Angeles, California, United States, 90095
Actively Recruiting
20
Valley Children's Hospital
Madera, California, United States, 93636
Actively Recruiting
21
Kaiser Permanente-Oakland
Oakland, California, United States, 94611
Actively Recruiting
22
Children's Hospital of Orange County
Orange, California, United States, 92868
Actively Recruiting
23
Lucile Packard Children's Hospital Stanford University
Palo Alto, California, United States, 94304
Actively Recruiting
24
Sutter Medical Center Sacramento
Sacramento, California, United States, 95816
Actively Recruiting
25
University of California Davis Comprehensive Cancer Center
Sacramento, California, United States, 95817
Actively Recruiting
26
Kaiser Permanente-San Diego Zion
San Diego, California, United States, 92120
Actively Recruiting
27
Rady Children's Hospital - San Diego
San Diego, California, United States, 92123
Actively Recruiting
28
UCSF Medical Center-Mission Bay
San Francisco, California, United States, 94158
Actively Recruiting
29
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Torrance, California, United States, 90502
Active, Not Recruiting
30
Children's Hospital Colorado
Aurora, Colorado, United States, 80045
Actively Recruiting
31
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center
Denver, Colorado, United States, 80218
Actively Recruiting
32
Connecticut Children's Medical Center
Hartford, Connecticut, United States, 06106
Actively Recruiting
33
Yale University
New Haven, Connecticut, United States, 06520
Actively Recruiting
34
Alfred I duPont Hospital for Children
Wilmington, Delaware, United States, 19803
Actively Recruiting
35
Children's National Medical Center
Washington D.C., District of Columbia, United States, 20010
Actively Recruiting
36
Golisano Children's Hospital of Southwest Florida
Fort Myers, Florida, United States, 33908
Actively Recruiting
37
University of Florida Health Science Center - Gainesville
Gainesville, Florida, United States, 32610
Actively Recruiting
38
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
Hollywood, Florida, United States, 33021
Actively Recruiting
39
Nemours Children's Clinic-Jacksonville
Jacksonville, Florida, United States, 32207
Actively Recruiting
40
AdventHealth Orlando
Orlando, Florida, United States, 32803
Actively Recruiting
41
Arnold Palmer Hospital for Children
Orlando, Florida, United States, 32806
Actively Recruiting
42
Nemours Children's Hospital
Orlando, Florida, United States, 32827
Actively Recruiting
43
Nemours Children's Clinic - Pensacola
Pensacola, Florida, United States, 32504
Actively Recruiting
44
Sacred Heart Hospital
Pensacola, Florida, United States, 32504
Suspended
45
Johns Hopkins All Children's Hospital
St. Petersburg, Florida, United States, 33701
Actively Recruiting
46
Tampa General Hospital
Tampa, Florida, United States, 33606
Actively Recruiting
47
Saint Joseph's Hospital/Children's Hospital-Tampa
Tampa, Florida, United States, 33607
Actively Recruiting
48
Saint Mary's Medical Center
West Palm Beach, Florida, United States, 33407
Actively Recruiting
49
Children's Healthcare of Atlanta - Arthur M Blank Hospital
Atlanta, Georgia, United States, 30329
Actively Recruiting
50
Memorial Health University Medical Center
Savannah, Georgia, United States, 31404
Actively Recruiting
51
Kapiolani Medical Center for Women and Children
Honolulu, Hawaii, United States, 96826
Actively Recruiting
52
Saint Luke's Cancer Institute - Boise
Boise, Idaho, United States, 83712
Actively Recruiting
53
Lurie Children's Hospital-Chicago
Chicago, Illinois, United States, 60611
Actively Recruiting
54
University of Illinois
Chicago, Illinois, United States, 60612
Actively Recruiting
55
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, United States, 60637
Actively Recruiting
56
Loyola University Medical Center
Maywood, Illinois, United States, 60153
Actively Recruiting
57
Saint Jude Midwest Affiliate
Peoria, Illinois, United States, 61637
Actively Recruiting
58
Riley Hospital for Children
Indianapolis, Indiana, United States, 46202
Actively Recruiting
59
Blank Children's Hospital
Des Moines, Iowa, United States, 50309
Actively Recruiting
60
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa, United States, 52242
Actively Recruiting
61
University of Kentucky/Markey Cancer Center
Lexington, Kentucky, United States, 40536
Actively Recruiting
62
Norton Children's Hospital
Louisville, Kentucky, United States, 40202
Actively Recruiting
63
Children's Hospital New Orleans
New Orleans, Louisiana, United States, 70118
Actively Recruiting
64
Ochsner Medical Center Jefferson
New Orleans, Louisiana, United States, 70121
Active, Not Recruiting
65
Maine Children's Cancer Program
Scarborough, Maine, United States, 04074
Actively Recruiting
66
Sinai Hospital of Baltimore
Baltimore, Maryland, United States, 21215
Actively Recruiting
67
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland, United States, 21287
Actively Recruiting
68
Walter Reed National Military Medical Center
Bethesda, Maryland, United States, 20889-5600
Active, Not Recruiting
69
Tufts Children's Hospital
Boston, Massachusetts, United States, 02111
Active, Not Recruiting
70
C S Mott Children's Hospital
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
71
Bronson Battle Creek
Battle Creek, Michigan, United States, 49017
Suspended
72
Corewell Health Dearborn Hospital
Dearborn, Michigan, United States, 48124
Suspended
73
Children's Hospital of Michigan
Detroit, Michigan, United States, 48201
Actively Recruiting
74
Michigan State University
East Lansing, Michigan, United States, 48823
Active, Not Recruiting
75
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids, Michigan, United States, 49503
Suspended
76
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
Grand Rapids, Michigan, United States, 49503
Actively Recruiting
77
Trinity Health Grand Rapids Hospital
Grand Rapids, Michigan, United States, 49503
Suspended
78
Bronson Methodist Hospital
Kalamazoo, Michigan, United States, 49007
Suspended
79
West Michigan Cancer Center
Kalamazoo, Michigan, United States, 49007
Suspended
80
Beacon Kalamazoo
Kalamazoo, Michigan, United States, 49048
Suspended
81
Trinity Health Muskegon Hospital
Muskegon, Michigan, United States, 49444
Suspended
82
Corewell Health Lakeland Hospitals - Niles Hospital
Niles, Michigan, United States, 49120
Suspended
83
Cancer and Hematology Centers of Western Michigan - Norton Shores
Norton Shores, Michigan, United States, 49444
Suspended
84
Corewell Health Reed City Hospital
Reed City, Michigan, United States, 49677
Suspended
85
Corewell Health Children's
Royal Oak, Michigan, United States, 48073
Actively Recruiting
86
Corewell Health William Beaumont University Hospital
Royal Oak, Michigan, United States, 48073
Suspended
87
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
Saint Joseph, Michigan, United States, 49085
Suspended
88
Corewell Health Lakeland Hospitals - Saint Joseph Hospital
Saint Joseph, Michigan, United States, 49085
Suspended
89
Munson Medical Center
Traverse City, Michigan, United States, 49684
Suspended
90
Corewell Health Beaumont Troy Hospital
Troy, Michigan, United States, 48085
Suspended
91
University of Michigan Health - West
Wyoming, Michigan, United States, 49519
Suspended
92
Children's Hospitals and Clinics of Minnesota - Minneapolis
Minneapolis, Minnesota, United States, 55404
Actively Recruiting
93
University of Minnesota/Masonic Cancer Center
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
94
University of Mississippi Medical Center
Jackson, Mississippi, United States, 39216
Actively Recruiting
95
Children's Mercy Hospitals and Clinics
Kansas City, Missouri, United States, 64108
Actively Recruiting
96
Cardinal Glennon Children's Medical Center
St Louis, Missouri, United States, 63104
Actively Recruiting
97
Washington University School of Medicine
St Louis, Missouri, United States, 63110
Actively Recruiting
98
Mercy Hospital Saint Louis
St Louis, Missouri, United States, 63141
Actively Recruiting
99
Children's Hospital and Medical Center of Omaha
Omaha, Nebraska, United States, 68114
Actively Recruiting
100
University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198
Actively Recruiting
101
Carson Tahoe Regional Medical Center
Carson City, Nevada, United States, 89703
Suspended
102
Comprehensive Cancer Centers of Nevada - Henderson
Henderson, Nevada, United States, 89052
Suspended
103
Comprehensive Cancer Centers of Nevada-Horizon Ridge
Henderson, Nevada, United States, 89052
Suspended
104
Las Vegas Cancer Center-Henderson
Henderson, Nevada, United States, 89052
Suspended
105
OptumCare Cancer Care at Seven Hills
Henderson, Nevada, United States, 89052
Suspended
106
Comprehensive Cancer Centers of Nevada-Southeast Henderson
Henderson, Nevada, United States, 89074
Suspended
107
OptumCare Cancer Care at Charleston
Las Vegas, Nevada, United States, 89102
Suspended
108
Hope Cancer Care of Nevada
Las Vegas, Nevada, United States, 89103
Suspended
109
Sunrise Hospital and Medical Center
Las Vegas, Nevada, United States, 89109
Suspended
110
Ann M Wierman MD LTD
Las Vegas, Nevada, United States, 89128
Suspended
111
Comprehensive Cancer Centers of Nevada - Northwest
Las Vegas, Nevada, United States, 89128
Suspended
112
OptumCare Cancer Care at MountainView
Las Vegas, Nevada, United States, 89128
Suspended
113
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Las Vegas, Nevada, United States, 89135
Actively Recruiting
114
Comprehensive Cancer Centers of Nevada - Town Center
Las Vegas, Nevada, United States, 89144
Suspended
115
Comprehensive Cancer Centers of Nevada-Summerlin
Las Vegas, Nevada, United States, 89144
Suspended
116
Summerlin Hospital Medical Center
Las Vegas, Nevada, United States, 89144
Actively Recruiting
117
Las Vegas Cancer Center-Medical Center
Las Vegas, Nevada, United States, 89148-2405
Suspended
118
Comprehensive Cancer Centers of Nevada
Las Vegas, Nevada, United States, 89148
Suspended
119
OptumCare Cancer Care at Fort Apache
Las Vegas, Nevada, United States, 89148
Suspended
120
Comprehensive Cancer Centers of Nevada - Central Valley
Las Vegas, Nevada, United States, 89169
Suspended
121
Hope Cancer Care of Nevada-Pahrump
Pahrump, Nevada, United States, 89048
Suspended
122
Renown Regional Medical Center
Reno, Nevada, United States, 89502
Actively Recruiting
123
Saint Mary's Regional Medical Center
Reno, Nevada, United States, 89503
Suspended
124
Cancer Care Specialists - Reno
Reno, Nevada, United States, 89511
Suspended
125
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, New Hampshire, United States, 03756
Actively Recruiting
126
Hackensack University Medical Center
Hackensack, New Jersey, United States, 07601
Actively Recruiting
127
Morristown Medical Center
Morristown, New Jersey, United States, 07960
Actively Recruiting
128
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
New Brunswick, New Jersey, United States, 08903
Actively Recruiting
129
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, United States, 08903
Actively Recruiting
130
Newark Beth Israel Medical Center
Newark, New Jersey, United States, 07112
Actively Recruiting
131
Saint Joseph's Regional Medical Center
Paterson, New Jersey, United States, 07503
Actively Recruiting
132
Albany Medical Center
Albany, New York, United States, 12208
Actively Recruiting
133
Maimonides Medical Center
Brooklyn, New York, United States, 11219
Actively Recruiting
134
NYU Langone Hospital - Long Island
Mineola, New York, United States, 11501
Actively Recruiting
135
The Steven and Alexandra Cohen Children's Medical Center of New York
New Hyde Park, New York, United States, 11040
Actively Recruiting
136
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, New York, United States, 10016
Actively Recruiting
137
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York, United States, 10032
Actively Recruiting
138
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
139
University of Rochester
Rochester, New York, United States, 14642
Active, Not Recruiting
140
Stony Brook University Medical Center
Stony Brook, New York, United States, 11794
Actively Recruiting
141
State University of New York Upstate Medical University
Syracuse, New York, United States, 13210
Actively Recruiting
142
Montefiore Medical Center - Moses Campus
The Bronx, New York, United States, 10467
Actively Recruiting
143
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, United States, 27599
Actively Recruiting
144
Carolinas Medical Center/Levine Cancer Institute
Charlotte, North Carolina, United States, 28203
Actively Recruiting
145
Duke University Medical Center
Durham, North Carolina, United States, 27710
Actively Recruiting
146
East Carolina University
Greenville, North Carolina, United States, 27834
Actively Recruiting
147
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States, 27157
Actively Recruiting
148
Sanford Broadway Medical Center
Fargo, North Dakota, United States, 58122
Actively Recruiting
149
Children's Hospital Medical Center of Akron
Akron, Ohio, United States, 44308
Actively Recruiting
150
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45229
Actively Recruiting
151
Rainbow Babies and Childrens Hospital
Cleveland, Ohio, United States, 44106
Actively Recruiting
152
Cleveland Clinic Foundation
Cleveland, Ohio, United States, 44195
Suspended
153
Nationwide Children's Hospital
Columbus, Ohio, United States, 43205
Actively Recruiting
154
Dayton Children's Hospital
Dayton, Ohio, United States, 45404
Actively Recruiting
155
ProMedica Flower Hospital
Sylvania, Ohio, United States, 43560
Suspended
156
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Toledo, Ohio, United States, 43606
Actively Recruiting
157
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States, 73104
Actively Recruiting
158
Legacy Emanuel Children's Hospital
Portland, Oregon, United States, 97227
Actively Recruiting
159
Oregon Health and Science University
Portland, Oregon, United States, 97239
Actively Recruiting
160
Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania, United States, 18103
Actively Recruiting
161
Geisinger Medical Center
Danville, Pennsylvania, United States, 17822
Actively Recruiting
162
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
163
Saint Christopher's Hospital for Children
Philadelphia, Pennsylvania, United States, 19134
Actively Recruiting
164
Children's Hospital of Pittsburgh of UPMC
Pittsburgh, Pennsylvania, United States, 15224
Actively Recruiting
165
Rhode Island Hospital
Providence, Rhode Island, United States, 02903
Actively Recruiting
166
Prisma Health Richland Hospital
Columbia, South Carolina, United States, 29203
Actively Recruiting
167
BI-LO Charities Children's Cancer Center
Greenville, South Carolina, United States, 29605
Actively Recruiting
168
Prisma Health Cancer Institute - Eastside
Greenville, South Carolina, United States, 29615
Actively Recruiting
169
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota, United States, 57117-5134
Actively Recruiting
170
East Tennessee Childrens Hospital
Knoxville, Tennessee, United States, 37916
Actively Recruiting
171
The Children's Hospital at TriStar Centennial
Nashville, Tennessee, United States, 37203
Actively Recruiting
172
Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee, United States, 37232
Actively Recruiting
173
Dell Children's Medical Center of Central Texas
Austin, Texas, United States, 78723
Actively Recruiting
174
Driscoll Children's Hospital
Corpus Christi, Texas, United States, 78411
Actively Recruiting
175
Medical City Dallas Hospital
Dallas, Texas, United States, 75230
Actively Recruiting
176
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, United States, 75390
Actively Recruiting
177
El Paso Children's Hospital
El Paso, Texas, United States, 79905
Actively Recruiting
178
Cook Children's Medical Center
Fort Worth, Texas, United States, 76104
Actively Recruiting
179
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
180
M D Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
181
Covenant Children's Hospital
Lubbock, Texas, United States, 79410
Actively Recruiting
182
UMC Cancer Center / UMC Health System
Lubbock, Texas, United States, 79415
Actively Recruiting
183
Children's Hospital of San Antonio
San Antonio, Texas, United States, 78207
Actively Recruiting
184
Methodist Children's Hospital of South Texas
San Antonio, Texas, United States, 78229
Actively Recruiting
185
University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States, 78229
Actively Recruiting
186
Primary Children's Hospital
Salt Lake City, Utah, United States, 84113
Actively Recruiting
187
University of Vermont and State Agricultural College
Burlington, Vermont, United States, 05405
Actively Recruiting
188
Inova Fairfax Hospital
Falls Church, Virginia, United States, 22042
Actively Recruiting
189
Children's Hospital of The King's Daughters
Norfolk, Virginia, United States, 23507
Actively Recruiting
190
Overlake Medical Center
Bellevue, Washington, United States, 98004
Suspended
191
Valley Medical Center
Renton, Washington, United States, 98055
Suspended
192
Seattle Children's Hospital
Seattle, Washington, United States, 98105
Actively Recruiting
193
Providence Sacred Heart Medical Center and Children's Hospital
Spokane, Washington, United States, 99204
Actively Recruiting
194
Mary Bridge Children's Hospital and Health Center
Tacoma, Washington, United States, 98405
Actively Recruiting
195
Madigan Army Medical Center
Tacoma, Washington, United States, 98431
Actively Recruiting
196
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Yakima, Washington, United States, 98902
Suspended
197
United Hospital Center
Bridgeport, West Virginia, United States, 26330
Suspended
198
WVUH-Berkely Medical Center
Martinsburg, West Virginia, United States, 25401
Suspended
199
West Virginia University Healthcare
Morgantown, West Virginia, United States, 26506
Suspended
200
Camden Clark Medical Center
Parkersburg, West Virginia, United States, 26101
Suspended
201
University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin, United States, 53792
Active, Not Recruiting
202
Children's Hospital of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
203
John Hunter Children's Hospital
Hunter Regional Mail Centre, New South Wales, Australia, 2310
Suspended
204
Sydney Children's Hospital
Randwick, New South Wales, Australia, 2031
Suspended
205
The Children's Hospital at Westmead
Westmead, New South Wales, Australia, 2145
Suspended
206
Queensland Children's Hospital
South Brisbane, Queensland, Australia, 4101
Suspended
207
Perth Children's Hospital
Perth, Western Australia, Australia, 6009
Suspended
208
CancerCare Manitoba
Winnipeg, Manitoba, Canada, R3E 0V9
Suspended
209
Janeway Child Health Centre
St. John's, Newfoundland and Labrador, Canada, A1B 3V6
Suspended
210
IWK Health Centre
Halifax, Nova Scotia, Canada, B3K 6R8
Suspended
211
The Montreal Children's Hospital of the MUHC
Montreal, Quebec, Canada, H3H 1P3
Actively Recruiting
212
Centre Hospitalier Universitaire Sainte-Justine
Montreal, Quebec, Canada, H3T 1C5
Actively Recruiting
213
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
Sherbrooke, Quebec, Canada, J1H 5N4
Actively Recruiting
214
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)
Québec, Canada, G1V 4G2
Actively Recruiting
215
University Pediatric Hospital
San Juan, Puerto Rico, 00926
Actively Recruiting
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How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
9
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Published Research Related To This Trial
Monoclonal antibodies: new chance in the management of B-cell acute lymphoblastic leukemia.
Zheng Shi, Yiqian Zhu, Jing Zhang...
https://pubmed.ncbi.nlm.nih.gov/35622074