Actively Recruiting
A Study to Compare Different Ways of Steroid Administration After Total Knee Implantation
Led by Christian Candrian · Updated on 2025-08-06
159
Participants Needed
1
Research Sites
669 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
We are going to evaluate the difference between perioperative intravenous steroid supplementation, perioperative periarticular steroid supplementation, and standard anaesthesia protocols. We'll evaluate the outcome of patients with knee osteoarthritis who are undergoing Total Knee Arthroplasty to understand which of the three treatments give more benefits to the patient.
CONDITIONS
Official Title
A Study to Compare Different Ways of Steroid Administration After Total Knee Implantation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients undergoing unilateral primary TKA at the Ospedale Regionale di Lugano.
- Patients with a BMI >18.5 and <35.
- Patients able to provide informed consent and follow all the study procedures as indicated by the protocol.
- Informed Consent as documented by signature (Appendix Informed Consent Form).
You will not qualify if you...
- Contraindications to steroids.
- Revision TKA.
- Active steroid therapy.
- Women who are pregnant or breast feeding.
- Presence of other clinically significant concomitant disease states (ASA IV).
- Uncontrolled diabetes mellitus
- Known or suspected non-compliance, drug or alcohol abuse.
- Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant.
- Participation in another study with investigational drug within the 30 days preceding and during the present study.
- Previous enrolment into the current study.
- Enrolment of the investigator, his/her family members, employees and other dependent persons.
AI-Screening
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Trial Site Locations
Total: 1 location
1
Ospedale Regionale di Lugano Civico e Italiano
Lugano, Switzerland, 6900
Actively Recruiting
Research Team
C
Christian Candrian, MD, Prof
CONTACT
M
Marco Delcogliano, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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