Actively Recruiting
A Study Comparing Anitocabtagene Autoleucel to Standard of Care Therapy in Participants With Relapsed/ Refractory Multiple Myeloma
Led by Kite, A Gilead Company · Updated on 2026-05-07
450
Participants Needed
124
Research Sites
357 weeks
Total Duration
On this page
Sponsors
K
Kite, A Gilead Company
Lead Sponsor
A
Arcellx, Inc.
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this study (iMMagine-3) is to compare the study drug, anitocabtagene autoleucel to standard of care therapy (SOCT) in participants with relapsed/refractory multiple myeloma who have received 1 to 3 prior lines of therapy, including an anti-CD38 monoclonal antibody and an immunomodulatory drug. The primary objective of this study is to compare the efficacy of anitocabtagene autoleucel versus SOCT in participants with RRMM.
CONDITIONS
Official Title
A Study Comparing Anitocabtagene Autoleucel to Standard of Care Therapy in Participants With Relapsed/ Refractory Multiple Myeloma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with multiple myeloma
- Received 1 to 3 prior antimyeloma treatments including an immunomodulatory drug and an anti-CD38 monoclonal antibody
- Evidence of disease progression within 12 months of last treatment
- Measurable disease by serum or urine tests
- Eligible for at least one of the four standard care regimens as per investigator
- ECOG performance status of 0 or 1
- Female participants of childbearing potential must have a negative pregnancy test
You will not qualify if you...
- Previous BCMA-targeted therapy
- Previous T-cell engager therapy
- Previous CAR or genetically modified T-cell therapy
- Central nervous system or meningeal involvement of multiple myeloma
- Cardiac atrial or ventricular involvement of multiple myeloma
- History of plasma cell leukemia, Waldenstrom's macroglobulinemia, POEMS syndrome, or amyloidosis
- Active cancer other than multiple myeloma requiring treatment within last 24 months
- Prior auto stem cell transplant within 12 weeks before study
- Prior allogeneic stem cell transplant
- High-dose systemic steroids or immunosuppressive therapy within 14 days before study
- Live vaccine within 4 weeks before study
- Contraindication to fludarabine or cyclophosphamide
- Allergy or severe hypersensitivity to study drugs or components including DMSO
- Life expectancy less than 12 weeks
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 124 locations
1
Banner MD Anderson Cancer Center
Gilbert, Arizona, United States, 85234
Active, Not Recruiting
2
Mayo Clinic Hospital
Gilbert, Arizona, United States, 85234
Active, Not Recruiting
3
City of Hope (City of Hope National Medical Center, City of Hope Medical Center)
Duarte, California, United States, 91010
Active, Not Recruiting
4
USC/Norris Comprehensive Cancer Center
Los Angeles, California, United States, 90033
Active, Not Recruiting
5
University of California Davis Comprehensive Cancer Center
Sacramento, California, United States, 95817
Active, Not Recruiting
6
UC San Diego Moores Cancer Center
San Diego, California, United States, 92037
Active, Not Recruiting
7
University of California San Francisco Medical Center
San Francisco, California, United States, 94143
Withdrawn
8
UCLA Hematology/Oncology (Bowyer Infusion Clinic)
Santa Monica, California, United States, 90404
Active, Not Recruiting
9
Stanford Cancer Institute
Stanford, California, United States, 94305
Active, Not Recruiting
10
Colorado Blood Cancer Institute
Denver, Colorado, United States, 80218
Active, Not Recruiting
11
Sylvester Comprehensive Cancer Center
Coral Gables, Florida, United States, 33146
Active, Not Recruiting
12
Mayo Clinic
Jacksonville, Florida, United States, 32256
Active, Not Recruiting
13
Moffitt Cancer Center
Tampa, Florida, United States, 33612
Active, Not Recruiting
14
Winship Cancer Institute, Emory University
Atlanta, Georgia, United States, 30322
Active, Not Recruiting
15
Southeastern Regional Medical Center, Inc. dba City of Hope Atlanta
Newnan, Georgia, United States, 30265
Active, Not Recruiting
16
St. Luke's Cancer Institute
Boise, Idaho, United States, 83712
Active, Not Recruiting
17
University of Illinois Hospital and Health Sciences System
Chicago, Illinois, United States, 60612
Active, Not Recruiting
18
IU Melvin and Bren Simon Comprehensive Cancer Center
Indianapolis, Indiana, United States, 46202
Active, Not Recruiting
19
Norton Cancer Institute, St. Matthews Campus
Louisville, Kentucky, United States, 40207
Active, Not Recruiting
20
Ochsner Clinical Foundation
New Orleans, Louisiana, United States, 70121
Active, Not Recruiting
21
University of Maryland Greenebaum Comprehensive Cancer Center
Baltimore, Maryland, United States, 21201
Active, Not Recruiting
22
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Active, Not Recruiting
23
Boston Medical Center
Boston, Massachusetts, United States, 02118
Active, Not Recruiting
24
University of Michigan
Ann Arbor, Michigan, United States, 48109
Active, Not Recruiting
25
Corewell Health - Lemmen-Holton Cancer Pavilion
Grand Rapids, Michigan, United States, 49503
Active, Not Recruiting
26
Mayo Clinic
Rochester, Minnesota, United States, 55902
Active, Not Recruiting
27
Oncology Hematology West, PC dba Nebraska Cancer Specialists - Legacy
Omaha, Nebraska, United States, 68130
Active, Not Recruiting
28
Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire, United States, 03756
Active, Not Recruiting
29
New Mexico Cancer Research Alliance
Albuquerque, New Mexico, United States, 87102
Active, Not Recruiting
30
Laura & Isaac Perlmutter Cancer Center at NYU Langone Health
New York, New York, United States, 10016
Active, Not Recruiting
31
Weill Cornell Medicine - New York Presbyterian Hosptial
New York, New York, United States, 10021
Active, Not Recruiting
32
Icahn School of Medicine at Mount Sinai
New York, New York, United States, 10029
Active, Not Recruiting
33
Levine Cancer Institute
Charlotte, North Carolina, United States, 28204
Actively Recruiting
34
Novant Health Cancer Institute - Hematology
Charlotte, North Carolina, United States, 28204
Active, Not Recruiting
35
Novant Health Cancer Institute Hematology- Forsyth
Winston-Salem, North Carolina, United States, 27103
Active, Not Recruiting
36
University of Cincinnati Cancer Center
Cincinnati, Ohio, United States, 45219
Active, Not Recruiting
37
Oncology Hematology Care Clinical Trials, LLC
Cincinnati, Ohio, United States, 45236
Active, Not Recruiting
38
Oregon Health and Science University
Portland, Oregon, United States, 97239
Active, Not Recruiting
39
University of Tennessee Medical Center
Knoxville, Tennessee, United States, 37920
Active, Not Recruiting
40
Baptist Cancer Center
Memphis, Tennessee, United States, 38104
Active, Not Recruiting
41
Tennessee Oncology, PLLC - Greco-Hainsworth Centers for Research
Nashville, Tennessee, United States, 37203
Active, Not Recruiting
42
Henry-Joyce Cancer Clinic
Nashville, Tennessee, United States, 37232
Active, Not Recruiting
43
St. David's South Austin Medical Center
Austin, Texas, United States, 78704
Active, Not Recruiting
44
Houston Methodist Hospital Cancer Center
Houston, Texas, United States, 77030
Active, Not Recruiting
45
The University of Texas MD Anderson Cancer Center
Houston, Texas, United States, 77030
Active, Not Recruiting
46
Huntsman Cancer Institute, University of Utah
Salt Lake City, Utah, United States, 84112
Active, Not Recruiting
47
LDS Hospital
Salt Lake City, Utah, United States, 84143
Active, Not Recruiting
48
Swedish Cancer Institute
Seattle, Washington, United States, 98104
Active, Not Recruiting
49
Fred Hutchinson Cancer Center
Seattle, Washington, United States, 98109
Active, Not Recruiting
50
West Virginia University
Morgantown, West Virginia, United States, 26506
Active, Not Recruiting
51
Royal Prince Alfred Hospital
Camperdown, New South Wales, Australia, NSW 2050
Active, Not Recruiting
52
Royal North Shore Hospital
St Leonards, New South Wales, Australia, 2065
Active, Not Recruiting
53
Royal Adelaide Hospital
Adelaide, South Australia, Australia, 5000
Active, Not Recruiting
54
Epworth HealthCare
Richmond, Victoria, Australia, 3121
Active, Not Recruiting
55
Sir Charles Gairdner Hospital
Nedlands, Western Australia, Australia, 6009
Active, Not Recruiting
56
Ordensklinikum Linz GmbH Elisabethinen, Hamatologie mit Stammzelltransplantation, Hamostaseologie und medizinische Onkologie
Linz, Austria
Active, Not Recruiting
57
Paracelsus Medizinischen Privatuniversitaet
Salzburg, Austria, A-5020
Active, Not Recruiting
58
University Hospital St. Poelten, Department of Internal Medicine I
Sankt Pölten, Austria, 3100
Active, Not Recruiting
59
Medical University of Vienna
Vienna, Austria, 1090
Active, Not Recruiting
60
Cliniques Universitaires Saint-Luc
Brussels, Belgium, 1200
Active, Not Recruiting
61
University Hospital of Antwerp
Edegem, Belgium
Active, Not Recruiting
62
UZ Leuven
Flemish Brabant, Belgium, 3000
Active, Not Recruiting
63
UZ Gent
Gent Oost-Vlaanderen, Belgium, 9000
Active, Not Recruiting
64
QEII Health Sciences Centre
Halifax, Canada, B3H 2Y9
Active, Not Recruiting
65
McGill University Health Center
Montreal, Canada, H4A 3J1
Active, Not Recruiting
66
The Ottawa Hospital - General Campus
Ottawa, Canada, K1H 8L6
Active, Not Recruiting
67
University Health Network - The Princess Margaret Cancer Centre
Toronto, Canada, M5G 2M9
Active, Not Recruiting
68
Fakultni Nemocnice Ostrava
Severomoravsky KRAJ, Czechia, 708 52
Active, Not Recruiting
69
CHU de Lille- Hopital Claude Huriez
Lille, France, 59037
Active, Not Recruiting
70
Institut Paoli Calmettes
Marseille, France, 13273
Active, Not Recruiting
71
CHU De Montpellier - Hopital Saint Eloi
Montpellier, France, 34080
Active, Not Recruiting
72
Centre Hospitalier Universitaire de Nantes
Nantes, France, 44093
Active, Not Recruiting
73
Hopital Saint Louis
Paris, France, 75010
Active, Not Recruiting
74
Hopital Saint Antoine
Paris, France, 75571
Active, Not Recruiting
75
Hôpital Lyon Sud
Pierre-Bénite, France, 69495
Active, Not Recruiting
76
Centre Hospitalier Universitaire de Poitiers
Poitiers, France, 86021
Active, Not Recruiting
77
CHU de Rennes
Rennes, France, 59037
Active, Not Recruiting
78
CHU de Toulouse. IUCT Oncopole
Toulouse, France, 31100
Active, Not Recruiting
79
Charité - Universitätsmedizin Berlin
Berlin, Germany, 12203
Actively Recruiting
80
Universitatsklinikum Koln, Klinik I fOr lnnere Medizin
Cologne, Germany
Actively Recruiting
81
Universitätsklinikum Essen
Essen, Germany
Actively Recruiting
82
Universitätsklinikum Freiburg
Freiburg im Breisgau, Germany, 79106
Actively Recruiting
83
Universitatsklinikum Hamburg Eppendorf
Hamburg, Germany, 20246
Actively Recruiting
84
Universitatsklinikum Leipzig
Leipzig, Germany, 4103
Actively Recruiting
85
TUM Klinikum, Rechts der Isar, Klinik und Poliklinik fur Innere Medizin III, Hamatologie und Onkologie
München, Germany, 80333
Actively Recruiting
86
Universitatsklinikum Wurzburg
Tübingen, Germany, 72076
Actively Recruiting
87
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, MI, Italy, 20133
Active, Not Recruiting
88
IRCCS AOU di Bologna
Bologna, Italy, 40138
Active, Not Recruiting
89
Ospedale San Raffaele
Milan, Italy, 3302
Active, Not Recruiting
90
Policlinico Universitario Argostino Gemelli
Roma, Italy, 00168
Active, Not Recruiting
91
AOU Città della Salute e della Scienza Presidio Ospedaliero Molinette
Torino, Italy, 10126
Active, Not Recruiting
92
Hyogo Medical University Hospital
Hyōgo, Japan, 663-8501
Active, Not Recruiting
93
Nagoya City University Hospital
Nagoya, Japan, 467-8602
Active, Not Recruiting
94
The University of Osaka Hospital
Osaka, Japan, 565-0871
Active, Not Recruiting
95
Hamamatsu University Hospital
Shizuoka, Japan, 431-3192
Active, Not Recruiting
96
Jichi Medical University Hospital
Tochigi, Japan, 329-0498
Active, Not Recruiting
97
Juntendo University School of Medicine Juntendo Clinic
Tokyo, Japan, 113-8431
Active, Not Recruiting
98
Japanese Red Cross Medical Center
Tokyo, Japan, 150-8935
Active, Not Recruiting
99
Amsterdam UMC - Location vUmc
Amsterdam, Netherlands, 1081 HV
Active, Not Recruiting
100
University Medical Center Groningen
Groningen, Netherlands, 9700 RB
Active, Not Recruiting
101
Erasmus Medical Center
Rotterdam, Netherlands, 3015GD
Active, Not Recruiting
102
Uniwersytecki Szpital Kliniczny w Poznaniu
Poznan, Poland, 60-569
Active, Not Recruiting
103
Warszawa-Uniwersyteckie Centrum Kliniczne Warszawskiego Uniwersytetu Medycznego
Warsaw, Poland, 02-097
Active, Not Recruiting
104
Instytut Hematologii i Transfuzjologii
Warsaw, Poland, 02-776
Active, Not Recruiting
105
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu
Wroclaw, Poland, 50-367
Active, Not Recruiting
106
ICO Badalona-H.U. Germans Trias i Pujol
Badalona, Spain, 08916
Active, Not Recruiting
107
Hospital Clínic de Barcelona
Barcelona, Spain, 08036
Active, Not Recruiting
108
Hospital Duran i Reynals
Barcelona, Spain, 08908
Active, Not Recruiting
109
Hospital Clinico Universitario Virgen de la Arrixaca
El Palmar, Spain, 30120
Active, Not Recruiting
110
Hospital Universitario Ramon Y Cajal
Madrid, Spain, 28034
Active, Not Recruiting
111
Hospital Universitario 12 de Octubre
Madrid, Spain, 28041
Active, Not Recruiting
112
Clinica Universidad de Navarra
Pamplona, Spain, 31008
Active, Not Recruiting
113
Complejo Asistencial Universitario de Salamanca
Salamanca, Spain, 37007
Active, Not Recruiting
114
Hospital Universitario Marqués de Valdecilla
Santander, Spain, 39008
Active, Not Recruiting
115
Hospital Universitario Virgen del Rocio
Seville, Spain, 41013
Active, Not Recruiting
116
Hospital Universitari i Politecnic La Fe de Valencia
Valencia, Spain, 46026
Active, Not Recruiting
117
Inselspital - Universitätsspital Bern
Bern, Switzerland, 3010
Active, Not Recruiting
118
Centre Hospitalier Universitaire Vaudois
Lausanne, Switzerland, CH-1011
Active, Not Recruiting
119
University Hospitals Bristol NHS Foundation Trust, Bristol Haematology and Oncology Centre
Bristol, United Kingdom, BS2 8ED
Active, Not Recruiting
120
University Hospital of Wales
Cardiff, United Kingdom, CF14 4XW
Active, Not Recruiting
121
Leeds Teaching Hospitals NHS Trust, St James's University Hospital
Leeds, United Kingdom, LS9 7TF
Active, Not Recruiting
122
King's College Hospital
London, United Kingdom, SE5 9NU
Active, Not Recruiting
123
University College London Hospital
London, United Kingdom, WC1E 6JN
Active, Not Recruiting
124
Newcastle Hospitals NHS Foundation Trust, Freeman Hospital
Newcastle, United Kingdom, NE7 7DN
Active, Not Recruiting
Research Team
M
Medical Information
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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