Actively Recruiting
A Study Comparing Cancer Imaging Approaches in People With Lobular Breast Cancer
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-02-27
30
Participants Needed
7
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study to compare two types of cancer imaging scans to see which is better at detecting and monitoring metastatic ILC. This study will compare PET/CT (positron emission tomography/computed tomography) scans using the radiotracer fluorine 18 (18F)-fluoroestradiol (FES) with a standard imaging approach for detecting and monitoring ILC, PET/CT scans using the radiotracer 18F-fluorodeoxyglucose (FDG). These scans will be referred to as FES PET/CT scans and FDG PET/CT scans.
CONDITIONS
Official Title
A Study Comparing Cancer Imaging Approaches in People With Lobular Breast Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patient > 18 years old
- Biopsy-proven metastatic invasive lobular carcinoma (ILC)
- Confirmed estrogen receptor positive (ER+) breast cancer with at least 10% tumor cells staining by immunohistochemistry (IHC)
- HER2-negative status according to ASCO/CAP guidelines
- Eastern Cooperative Oncology Group (ECOG) Performance Status of 0, 1, or 2
- Received up to 2 lines of therapy in the metastatic setting
- Life expectancy of at least 12 months
You will not qualify if you...
- Low estrogen receptor expression defined as less than 10% tumor cells staining by IHC
- Use of adjuvant ER-blocking endocrine therapy with SERM or SERD without required 8- and 24-week washout periods respectively
- Pregnancy, lactation, or currently nursing
- Presence of any other active, serious, or life-threatening medical or psychiatric condition
- Life expectancy less than 12 months
- Investigator judgment deeming the patient unsuitable for study participation
AI-Screening
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Trial Site Locations
Total: 7 locations
1
Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
2
Memorial Sloan Kettering Monmouth (Limited protocol activities)
Middletown, New Jersey, United States, 07748
Actively Recruiting
3
Memorial Sloan Kettering Bergen (All Protocol Activities)
Montvale, New Jersey, United States, 07645
Actively Recruiting
4
Memorial Sloan Kettering Suffolk-Commack (All protocol activity)
Commack, New York, United States, 11725
Actively Recruiting
5
Memorial Sloan Kettering Westchester (Limited Protocol Activities)
Harrison, New York, United States, 10604
Actively Recruiting
6
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, New York, United States, 10065
Actively Recruiting
7
Memorial Sloan Kettering Nassau (Limited Protocol Activites)
Rockville Centre, New York, United States, 11553
Actively Recruiting
Research Team
S
Somali Gavane, MD
CONTACT
K
Komal Jhaveri, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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