Actively Recruiting
A Study Comparing Perioperative Stress Reduction vs. Standard of Care in Ovarian Cancer (PRESERVE)
Led by Memorial Sloan Kettering Cancer Center · Updated on 2025-05-18
35
Participants Needed
7
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to see if propranolol and etodolac along with mind-body resilience training/MBRT and music therapy help participants who are experiencing physiological stress before, during, and after primary debulking surgery/PDS or IDS and also if it's better than the standard-of-care approach (no intervention for reducing stress).
CONDITIONS
Official Title
A Study Comparing Perioperative Stress Reduction vs. Standard of Care in Ovarian Cancer (PRESERVE)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Advanced (stage II-IV) epithelial ovarian, fallopian tube, or primary peritoneal carcinoma diagnosed by imaging, CA125, and clinical assessment
- Scheduled for exploratory laparotomy and primary or interval debulking surgery
- Surgery scheduled with at least 10 days lead time to allow 7 days of preoperative beta-blocker and COX2 inhibitor treatment
- Age 18 years or older
- ASA physical status score between 1 and 3
- Ability to understand study objectives, comply with protocol, and provide informed consent
You will not qualify if you...
- Chronic use of any beta-blocker or COX inhibitor
- Contraindications to beta-blockers, including asthma, advanced heart conduction blocks, sinus bradycardia, sick sinus syndrome, right-sided heart failure, pheochromocytoma, or peripheral vascular disease
- Contraindications to COX2 inhibitors, including renal failure (creatinine >1.5 mg/dL), significant liver failure (cirrhosis or bilirubin >2), active peptic disease, or current oral anticoagulant use
- Contraindication for regional epidural anesthesia
- Chronic autoimmune disease
- Active infection
- Pregnancy
- Minimally invasive surgical procedures
- Participation in another clinical trial interfering with this study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 7 locations
1
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
2
Memorial Sloan Kettering Monmouth (Limited protocol activities)
Middletown, New Jersey, United States, 07748
Actively Recruiting
3
Memorial Sloan Kettering Bergen (Limited Protocol Activities)
Montvale, New Jersey, United States, 07645
Actively Recruiting
4
Memorial Sloan Kettering Cancer Center @ Suffolk-Commack (Limited protocol activities)
Commack, New York, United States, 11725
Actively Recruiting
5
Memorial Sloan Kettering Westchester (Limited Protocol Activities)
Harrison, New York, United States, 10604
Actively Recruiting
6
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, New York, United States, 10065
Actively Recruiting
7
Memorial Sloan Kettering Nassau (Limited Protocol Activities)
Uniondale, New York, United States, 11553
Actively Recruiting
Research Team
K
Kara Long Roche, MD
CONTACT
A
Anoushka Afonso, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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