Study of Stress Reduction Treatments During Surgery for Advanced Ovarian and Related Cancers

What this Trial Is About

Researchers are evaluating if combining propranolol and etodolac with mind-body resilience training MBRT and music therapy can help women experiencing physiological stress around the time of primary debulking surgery PDS or interval debulking surgery IDS for ovarian cancer. The study compares this combined approach to the standard care, which does not include specific interventions to reduce stress. This trial is designed as a prospective randomized pilot study led by Memorial Sloan Kettering Cancer Center, focusing on stress prevention during surgery for advanced ovarian and related cancers. Participants in the intervention group will receive a combination of mind-body resilience training, music therapy, propranolol, and etodolac both before and after surgery. Propranolol is given at 20 mg twice daily for 21 days, then 10 mg twice daily for 3 days after surgery postoperative days 14-16. Etodolac is administered at 400 mg twice daily for 21 days. Psychological interventions may also be provided postoperatively if needed between days 1 to 7 after surgery. The comparison group will receive usual care without these specific stress-reduction interventions. During the study, participants will be monitored for adherence, including completing over 80% of the bundled interventions by 21 days after surgery. Researchers will assess the effectiveness of the interventions in reducing physiological stress around the time of surgery. Participation involves scheduled surgeries, medication administration, behavioral therapy sessions, and possible psychological support. The total study duration extends up to the primary completion date in June 2027, with follow-up focused on intervention adherence and stress response outcomes.

A Study Comparing Perioperative Stress Reduction vs. Standard of Care in Ovarian Cancer (PRESERVE)