Actively Recruiting
A Study Comparing Standard Treatments in People With Non-Muscle Invasive Bladder Cancer (NMIBC)
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-05-11
125
Participants Needed
9
Research Sites
155 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to compare the effectiveness of different FDA-approved/NCCN-recommended drug treatments for NMIBC. In particular, the FDA-approved drug nadofaragene firadenovec will be compared to usual care with other NCCN-recommended standard treatments for NMIBC (gemcitabine with or without docetaxel, mitomycin, re-treatment with BCG, or pembrolizumab).
CONDITIONS
Official Title
A Study Comparing Standard Treatments in People With Non-Muscle Invasive Bladder Cancer (NMIBC)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 21 years of age or older
- Diagnosed with high-grade NMIBC (Tis, Ta, or T1) and treated by a participating urologist
- Have had one or more prior induction courses of BCG, with treatment judged as failed by the urologist
- Received at least one instillation of any intravesical agent or one systemic therapy administration for NMIBC within the last 12 months
- No contraindications to nadofaragene firadenovec treatment as judged by the treating urologist
- Uncertainty exists whether nadofaragene firadenovec is better than best usual care
You will not qualify if you...
- Choosing to undergo radical cystectomy
- Currently participating in a clinical trial involving experimental therapy for NMIBC
- Prior treatment with nadofaragene firadenovec
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 9 locations
1
Johns Hopkins University (Data Collection Only)
Baltimore, Maryland, United States, 21287
Not Yet Recruiting
2
Memorial Sloan Kettering Basking Ridge (Consent Only)
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
3
Memorial Sloan Kettering Monmouth (Consent Only)
Middletown, New Jersey, United States, 07748
Actively Recruiting
4
Memorial Sloan Kettering Bergen (Consent Only)
Montvale, New Jersey, United States, 07645
Actively Recruiting
5
Memorial Sloan Kettering Suffolk - Commack (Consent Only)
Commack, New York, United States, 11725
Actively Recruiting
6
Memorial Sloan Kettering Westchester (Consent Only)
Harrison, New York, United States, 10604
Actively Recruiting
7
Columbia University (Data Collection Only)
New York, New York, United States, 10032
Not Yet Recruiting
8
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, New York, United States, 10065
Actively Recruiting
9
Memorial Sloan Kettering Nassau (Consent Only)
Uniondale, New York, United States, 11553
Actively Recruiting
Research Team
E
Eugene Pietzak, MD
CONTACT
B
Bernard Bochner, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here